Young-onset colorectal cancer
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset CRC or young-onset CRC (YO-CRC). YO-CRC is expected to account for 11% of colon cancers and 23% of rectal cancers by 2030. This trend is observed in dif...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/170589 |
| _version_ | 1826115945673785344 |
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| author | Spaander, Manon C. W. Zauber, Ann G. Syngal, Sapna Blaser, Martin J. Sung, Joseph Jao Yiu You, Y. Nancy Kuipers, Ernst J. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Spaander, Manon C. W. Zauber, Ann G. Syngal, Sapna Blaser, Martin J. Sung, Joseph Jao Yiu You, Y. Nancy Kuipers, Ernst J. |
| author_sort | Spaander, Manon C. W. |
| collection | NTU |
| description | In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset CRC or young-onset CRC (YO-CRC). YO-CRC is expected to account for 11% of colon cancers and 23% of rectal cancers by 2030. This trend is observed in different parts of the world and in both men and women. In 20% of patients with YO-CRC, a hereditary cancer syndrome is found as the underlying cause; however, in the majority of patients no genetic predisposition is present. Beginning in the 1950s, major changes in lifestyle such as antibiotic use, low physical activity and obesity have affected the gut microbiome and may be an important factor in YO-CRC development. Owing to a lack of screening, patients with YO-CRC are often diagnosed with advanced-stage disease. Long-term treatment-related complications should be taken into account in these younger patients, making the more traditional sequential approaches of drug therapy not always the most appropriate option. To better understand the underlying mechanism and define relationships between environmental factors and YO-CRC development, long-term prospective studies are needed with lifestyle data collected from childhood. |
| first_indexed | 2024-10-01T04:03:24Z |
| format | Journal Article |
| id | ntu-10356/170589 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:03:24Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1705892023-09-20T01:05:39Z Young-onset colorectal cancer Spaander, Manon C. W. Zauber, Ann G. Syngal, Sapna Blaser, Martin J. Sung, Joseph Jao Yiu You, Y. Nancy Kuipers, Ernst J. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Clinical-practice Guidelines Familial Adenomatous Polyposis In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset CRC or young-onset CRC (YO-CRC). YO-CRC is expected to account for 11% of colon cancers and 23% of rectal cancers by 2030. This trend is observed in different parts of the world and in both men and women. In 20% of patients with YO-CRC, a hereditary cancer syndrome is found as the underlying cause; however, in the majority of patients no genetic predisposition is present. Beginning in the 1950s, major changes in lifestyle such as antibiotic use, low physical activity and obesity have affected the gut microbiome and may be an important factor in YO-CRC development. Owing to a lack of screening, patients with YO-CRC are often diagnosed with advanced-stage disease. Long-term treatment-related complications should be taken into account in these younger patients, making the more traditional sequential approaches of drug therapy not always the most appropriate option. To better understand the underlying mechanism and define relationships between environmental factors and YO-CRC development, long-term prospective studies are needed with lifestyle data collected from childhood. 2023-09-20T01:05:39Z 2023-09-20T01:05:39Z 2023 Journal Article Spaander, M. C. W., Zauber, A. G., Syngal, S., Blaser, M. J., Sung, J. J. Y., You, Y. N. & Kuipers, E. J. (2023). Young-onset colorectal cancer. Nature Reviews Disease Primers, 9(1), 21-. https://dx.doi.org/10.1038/s41572-023-00432-7 2056-676X https://hdl.handle.net/10356/170589 10.1038/s41572-023-00432-7 37105987 2-s2.0-85157969885 1 9 21 en Nature Reviews Disease Primers © 2023 Springer Nature Limited. All rights reserved. |
| spellingShingle | Science::Medicine Clinical-practice Guidelines Familial Adenomatous Polyposis Spaander, Manon C. W. Zauber, Ann G. Syngal, Sapna Blaser, Martin J. Sung, Joseph Jao Yiu You, Y. Nancy Kuipers, Ernst J. Young-onset colorectal cancer |
| title | Young-onset colorectal cancer |
| title_full | Young-onset colorectal cancer |
| title_fullStr | Young-onset colorectal cancer |
| title_full_unstemmed | Young-onset colorectal cancer |
| title_short | Young-onset colorectal cancer |
| title_sort | young onset colorectal cancer |
| topic | Science::Medicine Clinical-practice Guidelines Familial Adenomatous Polyposis |
| url | https://hdl.handle.net/10356/170589 |
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