Nanocompartment-confined polymerization in living systems
Polymerization in living systems has become an effective strategy to regulate cell functions and behavior. However, the requirement of high concentrations of monomers, the existence of complicated intracorporal interferences, and the demand for extra external stimulations hinder their further biolog...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/170923 |
| _version_ | 1811693543638433792 |
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| author | Chen, Yun Zuo, Mengxuan Chen, Yu Yu, Peiyuan Chen, Xiaokai Zhang, Xiaodong Yuan, Wei Wu, Yinglong Zhu, Wei Zhao, Yanli |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Chen, Yun Zuo, Mengxuan Chen, Yu Yu, Peiyuan Chen, Xiaokai Zhang, Xiaodong Yuan, Wei Wu, Yinglong Zhu, Wei Zhao, Yanli |
| author_sort | Chen, Yun |
| collection | NTU |
| description | Polymerization in living systems has become an effective strategy to regulate cell functions and behavior. However, the requirement of high concentrations of monomers, the existence of complicated intracorporal interferences, and the demand for extra external stimulations hinder their further biological applications. Herein, a nanocompartment-confined strategy that provides a confined and secluded environment for monomer enrichment and isolation is developed to achieve high polymerization efficiency, reduce the interference from external environment, and realize broad-spectrum polymerizations in living systems. For exogenous photopolymerization, the light-mediated free-radical polymerization of sodium 4-styrenesulfonate induces a 2.7-fold increase in the reaction rate with the protection of a confined environment. For endogenous hydrogen peroxide-responsive polymerization, p‑aminodiphenylamine hydrochloride embedded in a nanocompartment not only performs a 6.4-fold higher reaction rate than that of free monomers, but also activates an effective second near-infrared photoacoustic imaging-guided photothermal immunotherapy at tumor sites. This nanocompartment-confined strategy breaks the shackles of conventional polymerization, providing a universal platform for in vivo synthesis of polymers with diverse structures and functions. |
| first_indexed | 2024-10-01T06:53:21Z |
| format | Journal Article |
| id | ntu-10356/170923 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:53:21Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1709232023-10-13T15:31:54Z Nanocompartment-confined polymerization in living systems Chen, Yun Zuo, Mengxuan Chen, Yu Yu, Peiyuan Chen, Xiaokai Zhang, Xiaodong Yuan, Wei Wu, Yinglong Zhu, Wei Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Engineering::Bioengineering Nanocompartment Confined Polymerization Immunogenic Cell Death Polymerization in living systems has become an effective strategy to regulate cell functions and behavior. However, the requirement of high concentrations of monomers, the existence of complicated intracorporal interferences, and the demand for extra external stimulations hinder their further biological applications. Herein, a nanocompartment-confined strategy that provides a confined and secluded environment for monomer enrichment and isolation is developed to achieve high polymerization efficiency, reduce the interference from external environment, and realize broad-spectrum polymerizations in living systems. For exogenous photopolymerization, the light-mediated free-radical polymerization of sodium 4-styrenesulfonate induces a 2.7-fold increase in the reaction rate with the protection of a confined environment. For endogenous hydrogen peroxide-responsive polymerization, p‑aminodiphenylamine hydrochloride embedded in a nanocompartment not only performs a 6.4-fold higher reaction rate than that of free monomers, but also activates an effective second near-infrared photoacoustic imaging-guided photothermal immunotherapy at tumor sites. This nanocompartment-confined strategy breaks the shackles of conventional polymerization, providing a universal platform for in vivo synthesis of polymers with diverse structures and functions. Ministry of Education (MOE) National Research Foundation (NRF) Published version This work was supported by the National Natural Science Foundation of China (21972047, W.Z.), the Guangdong Provincial Pearl River Talents Program (2019QN01Y314, W.Z.), the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08Y318, W.Z.), the Natural Science Foundation of Guangdong Province China (2021A1515220051, W.Z.), the Guangdong International Technology Cooperation Project (2022A0505050008, W.Z.), the China Postdoctoral Science Foundation (2022T150221, Yun Chen), the Guangdong Basic and Applied Basic Research Foundation (2022A1515110374, Yun Chen), the National Research Foundation Singapore under Its Competitive Research Programme (NRF-CRP26-2021-0002, Y.Z.), and the Ministry of Education Singapore under the Research Centres of Excellence Scheme (Institute for Digital Molecular Analytics and Science, Y.Z.). 2023-10-09T01:52:21Z 2023-10-09T01:52:21Z 2023 Journal Article Chen, Y., Zuo, M., Chen, Y., Yu, P., Chen, X., Zhang, X., Yuan, W., Wu, Y., Zhu, W. & Zhao, Y. (2023). Nanocompartment-confined polymerization in living systems. Nature Communications, 14(1), 5229-. https://dx.doi.org/10.1038/s41467-023-40935-1 2041-1723 https://hdl.handle.net/10356/170923 10.1038/s41467-023-40935-1 37634028 2-s2.0-85168720890 1 14 5229 en NRF-CRP26-2021-0002 Nature Communications © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Engineering::Bioengineering Nanocompartment Confined Polymerization Immunogenic Cell Death Chen, Yun Zuo, Mengxuan Chen, Yu Yu, Peiyuan Chen, Xiaokai Zhang, Xiaodong Yuan, Wei Wu, Yinglong Zhu, Wei Zhao, Yanli Nanocompartment-confined polymerization in living systems |
| title | Nanocompartment-confined polymerization in living systems |
| title_full | Nanocompartment-confined polymerization in living systems |
| title_fullStr | Nanocompartment-confined polymerization in living systems |
| title_full_unstemmed | Nanocompartment-confined polymerization in living systems |
| title_short | Nanocompartment-confined polymerization in living systems |
| title_sort | nanocompartment confined polymerization in living systems |
| topic | Engineering::Bioengineering Nanocompartment Confined Polymerization Immunogenic Cell Death |
| url | https://hdl.handle.net/10356/170923 |
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