A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway
The cholinergic system of the basal forebrain plays an integral part in behaviors ranging from attention to learning, partly by altering the impact of noise in neural populations. The circuit computations underlying cholinergic actions are confounded by recent findings that forebrain cholinergic neu...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/170928 |
| _version_ | 1824456022782115840 |
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| author | Nair, Aditya Teo, Yue Yang Augustine, George James Graf, Martin |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Nair, Aditya Teo, Yue Yang Augustine, George James Graf, Martin |
| author_sort | Nair, Aditya |
| collection | NTU |
| description | The cholinergic system of the basal forebrain plays an integral part in behaviors ranging from attention to learning, partly by altering the impact of noise in neural populations. The circuit computations underlying cholinergic actions are confounded by recent findings that forebrain cholinergic neurons corelease both acetylcholine (ACh) and GABA. We have identified that corelease of ACh and GABA by cholinergic inputs to the claustrum, a structure implicated in the control of attention, has opposing effects on the electrical activity of claustrum neurons that project to cortical vs. subcortical targets. These actions differentially alter neuronal gain and dynamic range in the two types of neurons. In model networks, the differential effects of ACh and GABA toggle network efficiency and the impact of noise on population dynamics between two different projection subcircuits. Such cholinergic switching between subcircuits provides a potential logic for neurotransmitter corelease in implementing behaviorally relevant computations. |
| first_indexed | 2025-02-19T03:47:30Z |
| format | Journal Article |
| id | ntu-10356/170928 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:47:30Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1709282023-10-15T15:38:51Z A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway Nair, Aditya Teo, Yue Yang Augustine, George James Graf, Martin Lee Kong Chian School of Medicine (LKCMedicine) Institute of Molecular and Cellular Biology, A*STAR National University of Singapore Science::Medicine Neurotransmitter Corelease Cholinergic The cholinergic system of the basal forebrain plays an integral part in behaviors ranging from attention to learning, partly by altering the impact of noise in neural populations. The circuit computations underlying cholinergic actions are confounded by recent findings that forebrain cholinergic neurons corelease both acetylcholine (ACh) and GABA. We have identified that corelease of ACh and GABA by cholinergic inputs to the claustrum, a structure implicated in the control of attention, has opposing effects on the electrical activity of claustrum neurons that project to cortical vs. subcortical targets. These actions differentially alter neuronal gain and dynamic range in the two types of neurons. In model networks, the differential effects of ACh and GABA toggle network efficiency and the impact of noise on population dynamics between two different projection subcircuits. Such cholinergic switching between subcircuits provides a potential logic for neurotransmitter corelease in implementing behaviorally relevant computations. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Published version Supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2017-T3- 1- 002). M.G. was supported by an LKCMedicine LEARN grant (021912- 00001), and A.N is supported by the National Science Scholarship awarded by the Agency of Science, Technology and Research, Singapore. 2023-10-09T02:34:14Z 2023-10-09T02:34:14Z 2023 Journal Article Nair, A., Teo, Y. Y., Augustine, G. J. & Graf, M. (2023). A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway. Proceedings of the National Academy of Sciences, 120(28), e2218830120-. https://dx.doi.org/10.1073/pnas.2218830120 0027-8424 https://hdl.handle.net/10356/170928 10.1073/pnas.2218830120 37399414 2-s2.0-85163982649 28 120 e2218830120 en MOE2017-T3-1-002 021912-00001 Proceedings of the National Academy of Sciences © 2023 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial- NoDerivatives License 4.0 (CC BY- NC-ND). application/pdf |
| spellingShingle | Science::Medicine Neurotransmitter Corelease Cholinergic Nair, Aditya Teo, Yue Yang Augustine, George James Graf, Martin A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| title | A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| title_full | A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| title_fullStr | A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| title_full_unstemmed | A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| title_short | A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| title_sort | functional logic for neurotransmitter corelease in the cholinergic forebrain pathway |
| topic | Science::Medicine Neurotransmitter Corelease Cholinergic |
| url | https://hdl.handle.net/10356/170928 |
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