Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines
Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients' lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tissues...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/170938 |
| _version_ | 1811696322688843776 |
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| author | Tang, Yufu Yu, Zhongzheng Lu, Xiaomei Fan, Qu-Li Huang, Wei |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Tang, Yufu Yu, Zhongzheng Lu, Xiaomei Fan, Qu-Li Huang, Wei |
| author_sort | Tang, Yufu |
| collection | NTU |
| description | Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients' lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tissues. Meanwhile, they can also nourish disease tissues, spread disease factors or cells into other healthy tissues, and deliver nanotheranostic agents to cover all the regions of a disease tissue. Thus, blood vessels are the first and the most important barrier for highly efficient nanotheranostics. Here, the structure and function of blood vessels are explored and how these characteristics affect nanotheranostics is discussed. Moreover, new mechanisms and related strategies about overcoming vascular obstacles for improved nanotheranostic outcomes are critically summarized, and their merits and demerits of each strategy are analyzed. Moreover, the present challenges to completely exhibit the potential of overcoming vascular barriers to improve the theranostic outcomes of nanomedicines in life science are also discussed. Finally, the future perspective is further discussed. |
| first_indexed | 2024-10-01T07:37:32Z |
| format | Journal Article |
| id | ntu-10356/170938 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:37:32Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1709382023-12-29T06:52:31Z Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines Tang, Yufu Yu, Zhongzheng Lu, Xiaomei Fan, Qu-Li Huang, Wei School of Chemical and Biomedical Engineering Engineering::Bioengineering Nanotheranostics Nanotheranostic Agent Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients' lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tissues. Meanwhile, they can also nourish disease tissues, spread disease factors or cells into other healthy tissues, and deliver nanotheranostic agents to cover all the regions of a disease tissue. Thus, blood vessels are the first and the most important barrier for highly efficient nanotheranostics. Here, the structure and function of blood vessels are explored and how these characteristics affect nanotheranostics is discussed. Moreover, new mechanisms and related strategies about overcoming vascular obstacles for improved nanotheranostic outcomes are critically summarized, and their merits and demerits of each strategy are analyzed. Moreover, the present challenges to completely exhibit the potential of overcoming vascular barriers to improve the theranostic outcomes of nanomedicines in life science are also discussed. Finally, the future perspective is further discussed. Published version This work was financially supported by the National Natural Science Foundation of China (No. 61905111), and the China Postdoctoral Science Foundation (Nos. 2019M651816 and 2020T130293). 2023-10-19T05:43:28Z 2023-10-19T05:43:28Z 2022 Journal Article Tang, Y., Yu, Z., Lu, X., Fan, Q. & Huang, W. (2022). Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines. Advanced Science, 9(13). https://dx.doi.org/10.1002/advs.202103148 2198-3844 https://hdl.handle.net/10356/170938 10.1002/advs.202103148 35246962 2-s2.0-85125581108 13 9 en Advanced Science © 2022 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Engineering::Bioengineering Nanotheranostics Nanotheranostic Agent Tang, Yufu Yu, Zhongzheng Lu, Xiaomei Fan, Qu-Li Huang, Wei Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| title | Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| title_full | Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| title_fullStr | Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| title_full_unstemmed | Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| title_short | Overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| title_sort | overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| topic | Engineering::Bioengineering Nanotheranostics Nanotheranostic Agent |
| url | https://hdl.handle.net/10356/170938 |
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