Prediction of G4 formation in live cells with epigenetic data: a deep learning approach
G-quadruplexes (G4s) are secondary structures abundant in DNA that may play regulatory roles in cells. Despite the ubiquity of the putative G-quadruplex-forming sequences (PQS) in the human genome, only a small fraction forms G4 structures in cells. Folded G4, histone methylation and chromatin acces...
Main Authors: | Korsakova, Anna, Phan, Anh Tuân |
---|---|
Other Authors: | School of Physical and Mathematical Sciences |
Format: | Journal Article |
Language: | English |
Published: |
2023
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/170987 |
Similar Items
-
Crystal structures of an HIV-1 integrase aptamer: formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex
by: Ngo, Khac Huy, et al.
Published: (2022) -
A novel minimal motif for left-handed G-quadruplex formation
by: Das, Poulomi, et al.
Published: (2021) -
Tetrad-binding ligands do not bind specifically to left-handed G-quadruplexes
by: Das, Poulomi, et al.
Published: (2023) -
DNA/RNA structure and processing in vitro and in cells: from probing to prediction
by: Korsakova, Anna
Published: (2023) -
Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter
by: Wang, Zi-Fu, et al.
Published: (2020)