Retinal oxygen extraction in patients with primary open-angle glaucoma
Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case−control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and...
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/171000 |
| _version_ | 1826121684614119424 |
|---|---|
| author | Garhöfer, Gerhard Bata, Ahmed M. Popa-Cherecheanu, Alina Hommer, Anton Vass, Clemens Resch, Hemma Schmidl, Doreen Werkmeister, René M. Schmetterer, Leopold |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Garhöfer, Gerhard Bata, Ahmed M. Popa-Cherecheanu, Alina Hommer, Anton Vass, Clemens Resch, Hemma Schmidl, Doreen Werkmeister, René M. Schmetterer, Leopold |
| author_sort | Garhöfer, Gerhard |
| collection | NTU |
| description | Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case−control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and 40 age- and sex-matched control subjects. Methods: Total retinal blood flow was measured using Doppler optical coherence tomography (OCT). Retinal arterial and venous oxygen saturation was measured using reflectance spectroscopy. From these parameters, oxygen content in the retinal arterial and venous circulation as well as total retinal oxygen extraction were calculated. Results: Total retinal blood flow was lower in POAG (25.2 ± 6.7 µL/min) as compared to healthy control subjects (35.6 ± 8.3 µL/min, p < 0.001). Retinal arterial oxygen content was not different between the two groups (0.18 ± 0.01 mL(O2)/mL in both groups, p < 0.761), but retinal venous oxygen content was higher in POAG (0.15 ± 0.01 mL(O2)/mL) than in healthy controls (0.14 ± 0.01 mL(O2)/mL p < 0.001). Accordingly, retinal oxygen extraction was reduced in POAG (0.8 ± 0.3 µL(O2)/min as compared to healthy controls: 1.4 ± 0.4 µL(O2)/min, p < 0.001). There was a significant association between total retinal blood flow and total retinal oxygen extraction with measures of structural and functional damage (p < 0.001 each). Conclusions: This study indicates that POAG is associated with a reduction in total retinal oxygen extraction linked to structural and functional damage of the disease. Since the technology is non-invasive, it allows for longitudinal studies investigating to which degree low retinal oxygen extraction is linked to the progression of the disease. |
| first_indexed | 2024-10-01T05:36:14Z |
| format | Journal Article |
| id | ntu-10356/171000 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:36:14Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1710002023-12-29T06:49:27Z Retinal oxygen extraction in patients with primary open-angle glaucoma Garhöfer, Gerhard Bata, Ahmed M. Popa-Cherecheanu, Alina Hommer, Anton Vass, Clemens Resch, Hemma Schmidl, Doreen Werkmeister, René M. Schmetterer, Leopold School of Chemical and Biomedical Engineering Singapore Eye Research Institute National University of Singapore SERI-NTU Advanced Ocular Engineering Science::Medicine Glaucoma Retinal Oxygen Extraction Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case−control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and 40 age- and sex-matched control subjects. Methods: Total retinal blood flow was measured using Doppler optical coherence tomography (OCT). Retinal arterial and venous oxygen saturation was measured using reflectance spectroscopy. From these parameters, oxygen content in the retinal arterial and venous circulation as well as total retinal oxygen extraction were calculated. Results: Total retinal blood flow was lower in POAG (25.2 ± 6.7 µL/min) as compared to healthy control subjects (35.6 ± 8.3 µL/min, p < 0.001). Retinal arterial oxygen content was not different between the two groups (0.18 ± 0.01 mL(O2)/mL in both groups, p < 0.761), but retinal venous oxygen content was higher in POAG (0.15 ± 0.01 mL(O2)/mL) than in healthy controls (0.14 ± 0.01 mL(O2)/mL p < 0.001). Accordingly, retinal oxygen extraction was reduced in POAG (0.8 ± 0.3 µL(O2)/min as compared to healthy controls: 1.4 ± 0.4 µL(O2)/min, p < 0.001). There was a significant association between total retinal blood flow and total retinal oxygen extraction with measures of structural and functional damage (p < 0.001 each). Conclusions: This study indicates that POAG is associated with a reduction in total retinal oxygen extraction linked to structural and functional damage of the disease. Since the technology is non-invasive, it allows for longitudinal studies investigating to which degree low retinal oxygen extraction is linked to the progression of the disease. Published version Financial support from the Austrian Science Foundation FWF Projects Grant numbers KLI854 and KLI721 are gratefully acknowledged. 2023-10-10T03:32:05Z 2023-10-10T03:32:05Z 2022 Journal Article Garhöfer, G., Bata, A. M., Popa-Cherecheanu, A., Hommer, A., Vass, C., Resch, H., Schmidl, D., Werkmeister, R. M. & Schmetterer, L. (2022). Retinal oxygen extraction in patients with primary open-angle glaucoma. International Journal of Molecular Sciences, 23(17), 10152-. https://dx.doi.org/10.3390/ijms231710152 1661-6596 https://hdl.handle.net/10356/171000 10.3390/ijms231710152 36077550 2-s2.0-85137599662 17 23 10152 en International Journal of Molecular Sciences © 2022 The authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Science::Medicine Glaucoma Retinal Oxygen Extraction Garhöfer, Gerhard Bata, Ahmed M. Popa-Cherecheanu, Alina Hommer, Anton Vass, Clemens Resch, Hemma Schmidl, Doreen Werkmeister, René M. Schmetterer, Leopold Retinal oxygen extraction in patients with primary open-angle glaucoma |
| title | Retinal oxygen extraction in patients with primary open-angle glaucoma |
| title_full | Retinal oxygen extraction in patients with primary open-angle glaucoma |
| title_fullStr | Retinal oxygen extraction in patients with primary open-angle glaucoma |
| title_full_unstemmed | Retinal oxygen extraction in patients with primary open-angle glaucoma |
| title_short | Retinal oxygen extraction in patients with primary open-angle glaucoma |
| title_sort | retinal oxygen extraction in patients with primary open angle glaucoma |
| topic | Science::Medicine Glaucoma Retinal Oxygen Extraction |
| url | https://hdl.handle.net/10356/171000 |
| work_keys_str_mv | AT garhofergerhard retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT bataahmedm retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT popacherecheanualina retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT hommeranton retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT vassclemens retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT reschhemma retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT schmidldoreen retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT werkmeisterrenem retinaloxygenextractioninpatientswithprimaryopenangleglaucoma AT schmettererleopold retinaloxygenextractioninpatientswithprimaryopenangleglaucoma |