Molecular radio afterglow probes for cancer radiodynamic theranostics
X-ray-induced afterglow and radiodynamic therapy tackle the tissue penetration issue of optical imaging and phototherapy. However, inorganic nanophosphors used in this therapy have their radio afterglow dynamic function as always on, limiting the detection specificity and treatment efficacy. Here we...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/171019 |
| _version_ | 1811693359815720960 |
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| author | Huang, Jingsheng Su, Lichao Xu, Cheng Ge, Xiaoguang Zhang, Ruiping Song, Jibin Pu, Kanyi |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Huang, Jingsheng Su, Lichao Xu, Cheng Ge, Xiaoguang Zhang, Ruiping Song, Jibin Pu, Kanyi |
| author_sort | Huang, Jingsheng |
| collection | NTU |
| description | X-ray-induced afterglow and radiodynamic therapy tackle the tissue penetration issue of optical imaging and phototherapy. However, inorganic nanophosphors used in this therapy have their radio afterglow dynamic function as always on, limiting the detection specificity and treatment efficacy. Here we report organic luminophores (IDPAs) with near-infrared afterglow and 1O2 production after X-ray irradiation for cancer theranostics. The in vivo radio afterglow of IDPAs is >25.0 times brighter than reported inorganic nanophosphors, whereas the radiodynamic production of 1O2 is >5.7 times higher than commercially available radio sensitizers. The modular structure of IDPAs permits the development of a smart molecular probe that only triggers its radio afterglow dynamic function in the presence of a cancer biomarker. Thus, the probe enables the ultrasensitive detection of a diminutive tumour (0.64 mm) with superb contrast (tumour-to-background ratio of 234) and tumour-specific radiotherapy for brain tumour with molecular precision at low dosage. Our work reveals the molecular guidelines towards organic radio afterglow agents and highlights new opportunities for cancer radio theranostics. |
| first_indexed | 2024-10-01T06:50:26Z |
| format | Journal Article |
| id | ntu-10356/171019 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:50:26Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1710192023-10-15T15:38:33Z Molecular radio afterglow probes for cancer radiodynamic theranostics Huang, Jingsheng Su, Lichao Xu, Cheng Ge, Xiaoguang Zhang, Ruiping Song, Jibin Pu, Kanyi Lee Kong Chian School of Medicine (LKCMedicine) School of Chemistry, Chemical Engineering and Biotechnology Science::Medicine Diseases Infrared Devices X-ray-induced afterglow and radiodynamic therapy tackle the tissue penetration issue of optical imaging and phototherapy. However, inorganic nanophosphors used in this therapy have their radio afterglow dynamic function as always on, limiting the detection specificity and treatment efficacy. Here we report organic luminophores (IDPAs) with near-infrared afterglow and 1O2 production after X-ray irradiation for cancer theranostics. The in vivo radio afterglow of IDPAs is >25.0 times brighter than reported inorganic nanophosphors, whereas the radiodynamic production of 1O2 is >5.7 times higher than commercially available radio sensitizers. The modular structure of IDPAs permits the development of a smart molecular probe that only triggers its radio afterglow dynamic function in the presence of a cancer biomarker. Thus, the probe enables the ultrasensitive detection of a diminutive tumour (0.64 mm) with superb contrast (tumour-to-background ratio of 234) and tumour-specific radiotherapy for brain tumour with molecular precision at low dosage. Our work reveals the molecular guidelines towards organic radio afterglow agents and highlights new opportunities for cancer radio theranostics. Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version K.P. thanks Singapore National Research Foundation (NRF) (NRF-NRFI07-2021-0005) and the Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19, RT05/20) and Academic Research Fund Tier 2 (MOE-T2EP30220-0010, MOE-T2EP30221-0004) for financial support. R.Z. thanks the Nature Materials Article https://doi.org/10.1038/s41563-023-01659-1 National Natural Science Foundation of China (nos. 82120108016 and 82071987) for financial support. J.S. thanks the National Natural Science Foundation of China (No. U22A20348, U21A20377) and the Natural Science Foundation of Fujian Province (No. 2020J02012). 2023-10-10T05:39:10Z 2023-10-10T05:39:10Z 2023 Journal Article Huang, J., Su, L., Xu, C., Ge, X., Zhang, R., Song, J. & Pu, K. (2023). Molecular radio afterglow probes for cancer radiodynamic theranostics. Nature Materials. https://dx.doi.org/10.1038/s41563-023-01659-1 1476-1122 https://hdl.handle.net/10356/171019 10.1038/s41563-023-01659-1 37667071 2-s2.0-85169824401 en NRF-NRFI07-2021-0005 2019-T1-002-045 RG125/19 RT05/20 MOE-T2EP30220-0010 MOE-T2EP30221-0004 Nature Materials © 2023 The Author(s), under exclusive licence to Springer Nature Limited. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1038/s41563-023-01659-1. application/pdf |
| spellingShingle | Science::Medicine Diseases Infrared Devices Huang, Jingsheng Su, Lichao Xu, Cheng Ge, Xiaoguang Zhang, Ruiping Song, Jibin Pu, Kanyi Molecular radio afterglow probes for cancer radiodynamic theranostics |
| title | Molecular radio afterglow probes for cancer radiodynamic theranostics |
| title_full | Molecular radio afterglow probes for cancer radiodynamic theranostics |
| title_fullStr | Molecular radio afterglow probes for cancer radiodynamic theranostics |
| title_full_unstemmed | Molecular radio afterglow probes for cancer radiodynamic theranostics |
| title_short | Molecular radio afterglow probes for cancer radiodynamic theranostics |
| title_sort | molecular radio afterglow probes for cancer radiodynamic theranostics |
| topic | Science::Medicine Diseases Infrared Devices |
| url | https://hdl.handle.net/10356/171019 |
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