New mechanical markers for tracking the progression of myocardial infarction
The mechanical properties of soft tissues can often be strongly correlated with the progression of various diseases, such as myocardial infarction (MI). However, the dynamic mechanical properties of cardiac tissues during MI progression remain poorly understood. Herein, we investigate the rheologica...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/171048 |
| _version_ | 1811695522147205120 |
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| author | Chang, Zhuo Zhang, Jing Liu, Yilun Gao, Huajian Xu, Guang-Kui |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Chang, Zhuo Zhang, Jing Liu, Yilun Gao, Huajian Xu, Guang-Kui |
| author_sort | Chang, Zhuo |
| collection | NTU |
| description | The mechanical properties of soft tissues can often be strongly correlated with the progression of various diseases, such as myocardial infarction (MI). However, the dynamic mechanical properties of cardiac tissues during MI progression remain poorly understood. Herein, we investigate the rheological responses of cardiac tissues at different stages of MI (i.e., early-stage, mid-stage, and late-stage) with atomic force microscopy-based microrheology. Surprisingly, we discover that all cardiac tissues exhibit a universal two-stage power-law rheological behavior at different time scales. The experimentally found power-law exponents can capture an inconspicuous initial rheological change, making them particularly suitable as markers for early-stage MI diagnosis. We further develop a self-similar hierarchical model to characterize the progressive mechanical changes from subcellular to tissue scales. The theoretically calculated mechanical indexes are found to markedly vary among different stages of MI. These new mechanical markers are applicable for tracking the subtle changes of cardiac tissues during MI progression. |
| first_indexed | 2024-10-01T07:24:48Z |
| format | Journal Article |
| id | ntu-10356/171048 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:24:48Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1710482023-10-14T16:48:31Z New mechanical markers for tracking the progression of myocardial infarction Chang, Zhuo Zhang, Jing Liu, Yilun Gao, Huajian Xu, Guang-Kui School of Mechanical and Aerospace Engineering Institute of High Performance Computing, A*STAR Engineering::Mechanical engineering Biomechanics Viscoelasticity The mechanical properties of soft tissues can often be strongly correlated with the progression of various diseases, such as myocardial infarction (MI). However, the dynamic mechanical properties of cardiac tissues during MI progression remain poorly understood. Herein, we investigate the rheological responses of cardiac tissues at different stages of MI (i.e., early-stage, mid-stage, and late-stage) with atomic force microscopy-based microrheology. Surprisingly, we discover that all cardiac tissues exhibit a universal two-stage power-law rheological behavior at different time scales. The experimentally found power-law exponents can capture an inconspicuous initial rheological change, making them particularly suitable as markers for early-stage MI diagnosis. We further develop a self-similar hierarchical model to characterize the progressive mechanical changes from subcellular to tissue scales. The theoretically calculated mechanical indexes are found to markedly vary among different stages of MI. These new mechanical markers are applicable for tracking the subtle changes of cardiac tissues during MI progression. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University Published version Financial support from the National Natural Science Foundation of China (Grant Nos. 12122210, 12072252, and 12102326), the Fundamental Research Funds for the Central Universities of China, the research start-up grant (002479-00001) from Nanyang Technological University, and the Agency for Science, Technology and Research (A*STAR) is acknowledged. 2023-10-10T07:41:41Z 2023-10-10T07:41:41Z 2023 Journal Article Chang, Z., Zhang, J., Liu, Y., Gao, H. & Xu, G. (2023). New mechanical markers for tracking the progression of myocardial infarction. Nano Letters, 23(16), 7350-7357. https://dx.doi.org/10.1021/acs.nanolett.3c01712 1530-6984 https://hdl.handle.net/10356/171048 10.1021/acs.nanolett.3c01712 37580044 2-s2.0-85168788716 16 23 7350 7357 en 002479-00001 Nano Letters © 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0. application/pdf |
| spellingShingle | Engineering::Mechanical engineering Biomechanics Viscoelasticity Chang, Zhuo Zhang, Jing Liu, Yilun Gao, Huajian Xu, Guang-Kui New mechanical markers for tracking the progression of myocardial infarction |
| title | New mechanical markers for tracking the progression of myocardial infarction |
| title_full | New mechanical markers for tracking the progression of myocardial infarction |
| title_fullStr | New mechanical markers for tracking the progression of myocardial infarction |
| title_full_unstemmed | New mechanical markers for tracking the progression of myocardial infarction |
| title_short | New mechanical markers for tracking the progression of myocardial infarction |
| title_sort | new mechanical markers for tracking the progression of myocardial infarction |
| topic | Engineering::Mechanical engineering Biomechanics Viscoelasticity |
| url | https://hdl.handle.net/10356/171048 |
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