Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose
Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vacc...
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/171167 |
| _version_ | 1826119076345282560 |
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| author | Renia, Laurent Goh, Yun Shan Rouers, Angeline Bert, Nina Le Chia, Wan Ni Chavatte, Jean-Marc Fong, Siew-Wai Chang, Zi Wei Zhuo, Nicole Ziyi Tay. Matthew Zirui Chan, Yi-Hao Tan Chee Wah Yeo, Nicholas Kim-Wah Amrun, Siti Naqiah Huang, Yuling Wong, Joel Xu En Hor, Pei Xiang Loh, Chiew Yee Wang, Bei Ngoh, Eve Zi Xian Salleh, Siti Nazihah Mohd Salleh Carissimo, Guillaume Dowla, Samanzer Lim, Alicia Jieling Zhang, Jinyan Lim, Joey Ming Er Wang, Cheng-I. Ding, Ying Pada, Surinder Sun, Lousia Jin Somani, Jyoti Lee, Eng Sing Ong, Desmond Luan Seng Leo, Yee-Sin MacAry, Paul A. Lin, Raymond Tzer Pin Wang, Lin-Fa Ren, Ee Chee Lye, David C. Bertoletti, Antonio Young, Barnaby Edward Ng, Lisa F. P. Ruesta, Torres Anthony Neo, Vanessa Chen, Wendy Yehui Goh, Estelle Yi Wei Ong, Alice Soh Meoy Chua, Adeline Chiew Yen Nguee, Samantha Yee Teng Tan, Yong Jie Tang, Weiyi |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Renia, Laurent Goh, Yun Shan Rouers, Angeline Bert, Nina Le Chia, Wan Ni Chavatte, Jean-Marc Fong, Siew-Wai Chang, Zi Wei Zhuo, Nicole Ziyi Tay. Matthew Zirui Chan, Yi-Hao Tan Chee Wah Yeo, Nicholas Kim-Wah Amrun, Siti Naqiah Huang, Yuling Wong, Joel Xu En Hor, Pei Xiang Loh, Chiew Yee Wang, Bei Ngoh, Eve Zi Xian Salleh, Siti Nazihah Mohd Salleh Carissimo, Guillaume Dowla, Samanzer Lim, Alicia Jieling Zhang, Jinyan Lim, Joey Ming Er Wang, Cheng-I. Ding, Ying Pada, Surinder Sun, Lousia Jin Somani, Jyoti Lee, Eng Sing Ong, Desmond Luan Seng Leo, Yee-Sin MacAry, Paul A. Lin, Raymond Tzer Pin Wang, Lin-Fa Ren, Ee Chee Lye, David C. Bertoletti, Antonio Young, Barnaby Edward Ng, Lisa F. P. Ruesta, Torres Anthony Neo, Vanessa Chen, Wendy Yehui Goh, Estelle Yi Wei Ong, Alice Soh Meoy Chua, Adeline Chiew Yen Nguee, Samantha Yee Teng Tan, Yong Jie Tang, Weiyi |
| author_sort | Renia, Laurent |
| collection | NTU |
| description | Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vaccine. Two vaccine doses induce high antibody and T cell responses in most individuals. However, antibody recognition of the Spike protein of the Delta and Omicron variants is less efficient than that of the ancestral Wuhan strain. Age-stratified analyses identify a group of low antibody responders where individuals ≥60 years are overrepresented. Waning of the antibody and cellular responses is observed in 30% of the vaccinees after 6 months. However, age does not influence the waning of these responses. Taken together, while individuals ≥60 years old take longer to acquire vaccine-induced immunity, they develop more sustained acquired immunity at 6 months post-vaccination. A third dose strongly boosts the low antibody responses in the older individuals against the ancestral Wuhan strain, Delta and Omicron variants. |
| first_indexed | 2024-10-01T04:53:49Z |
| format | Journal Article |
| id | ntu-10356/171167 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:53:49Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1711672023-10-29T15:37:57Z Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose Renia, Laurent Goh, Yun Shan Rouers, Angeline Bert, Nina Le Chia, Wan Ni Chavatte, Jean-Marc Fong, Siew-Wai Chang, Zi Wei Zhuo, Nicole Ziyi Tay. Matthew Zirui Chan, Yi-Hao Tan Chee Wah Yeo, Nicholas Kim-Wah Amrun, Siti Naqiah Huang, Yuling Wong, Joel Xu En Hor, Pei Xiang Loh, Chiew Yee Wang, Bei Ngoh, Eve Zi Xian Salleh, Siti Nazihah Mohd Salleh Carissimo, Guillaume Dowla, Samanzer Lim, Alicia Jieling Zhang, Jinyan Lim, Joey Ming Er Wang, Cheng-I. Ding, Ying Pada, Surinder Sun, Lousia Jin Somani, Jyoti Lee, Eng Sing Ong, Desmond Luan Seng Leo, Yee-Sin MacAry, Paul A. Lin, Raymond Tzer Pin Wang, Lin-Fa Ren, Ee Chee Lye, David C. Bertoletti, Antonio Young, Barnaby Edward Ng, Lisa F. P. Ruesta, Torres Anthony Neo, Vanessa Chen, Wendy Yehui Goh, Estelle Yi Wei Ong, Alice Soh Meoy Chua, Adeline Chiew Yen Nguee, Samantha Yee Teng Tan, Yong Jie Tang, Weiyi Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Science::Biological sciences Recombinant Vaccine Prevention and Control Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vaccine. Two vaccine doses induce high antibody and T cell responses in most individuals. However, antibody recognition of the Spike protein of the Delta and Omicron variants is less efficient than that of the ancestral Wuhan strain. Age-stratified analyses identify a group of low antibody responders where individuals ≥60 years are overrepresented. Waning of the antibody and cellular responses is observed in 30% of the vaccinees after 6 months. However, age does not influence the waning of these responses. Taken together, while individuals ≥60 years old take longer to acquire vaccine-induced immunity, they develop more sustained acquired immunity at 6 months post-vaccination. A third dose strongly boosts the low antibody responses in the older individuals against the ancestral Wuhan strain, Delta and Omicron variants. Agency for Science, Technology and Research (A*STAR) Singapore Infectious Diseases Initiative - National Medical Research Council Published version This work was supported by the Biomedical Research Council (BMRC), A*CRUSE (Vaccine monitoring project), the A*ccelerate GAP-funded project (ACCL/19-GAP064-R20H-H) from Agency of Science, Technology and Research (A*STAR), Singapore National Medical Research Council COVID-19 Research Fund (COVID19RF-001; COVID19RF-007; COVID19RF-0008; COVID19RF-011, COVID19RF-060) (LR, LFPN, DCL, BEY), US Food and Drug Administration (#75F40120C00085) (LR, LN), and A*STAR COVID-19 Research funding (H/20/04/g1/006) (LR, WCI, LFPN). 2023-10-23T06:35:00Z 2023-10-23T06:35:00Z 2022 Journal Article Renia, L., Goh, Y. S., Rouers, A., Bert, N. L., Chia, W. N., Chavatte, J., Fong, S., Chang, Z. W., Zhuo, N. Z., Tay. Matthew Zirui, Chan, Y., Tan Chee Wah, Yeo, N. K., Amrun, S. N., Huang, Y., Wong, J. X. E., Hor, P. X., Loh, C. Y., Wang, B., ...Tang, W. (2022). Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose. Nature Communications, 13(1), 4615-. https://dx.doi.org/10.1038/s41467-022-32312-1 2041-1723 https://hdl.handle.net/10356/171167 10.1038/s41467-022-32312-1 35941158 2-s2.0-85135551151 1 13 4615 en COVID19RF-001 COVID19RF-007 COVID19RF-0008 COVID19RF-011 COVID19RF-060 H/20/04/g1/006 Nature Communications © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Science::Biological sciences Recombinant Vaccine Prevention and Control Renia, Laurent Goh, Yun Shan Rouers, Angeline Bert, Nina Le Chia, Wan Ni Chavatte, Jean-Marc Fong, Siew-Wai Chang, Zi Wei Zhuo, Nicole Ziyi Tay. Matthew Zirui Chan, Yi-Hao Tan Chee Wah Yeo, Nicholas Kim-Wah Amrun, Siti Naqiah Huang, Yuling Wong, Joel Xu En Hor, Pei Xiang Loh, Chiew Yee Wang, Bei Ngoh, Eve Zi Xian Salleh, Siti Nazihah Mohd Salleh Carissimo, Guillaume Dowla, Samanzer Lim, Alicia Jieling Zhang, Jinyan Lim, Joey Ming Er Wang, Cheng-I. Ding, Ying Pada, Surinder Sun, Lousia Jin Somani, Jyoti Lee, Eng Sing Ong, Desmond Luan Seng Leo, Yee-Sin MacAry, Paul A. Lin, Raymond Tzer Pin Wang, Lin-Fa Ren, Ee Chee Lye, David C. Bertoletti, Antonio Young, Barnaby Edward Ng, Lisa F. P. Ruesta, Torres Anthony Neo, Vanessa Chen, Wendy Yehui Goh, Estelle Yi Wei Ong, Alice Soh Meoy Chua, Adeline Chiew Yen Nguee, Samantha Yee Teng Tan, Yong Jie Tang, Weiyi Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
| title | Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
| title_full | Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
| title_fullStr | Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
| title_full_unstemmed | Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
| title_short | Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
| title_sort | lower vaccine acquired immunity in the elderly population following two dose bnt162b2 vaccination is alleviated by a third vaccine dose |
| topic | Science::Biological sciences Recombinant Vaccine Prevention and Control |
| url | https://hdl.handle.net/10356/171167 |
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