Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing
The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack of biological activity. Humic acids (HAs) show photothermal activity and can be used as a photosensitizer for photothermal therapy. In the presenc...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/171282 |
| _version_ | 1824456146770984960 |
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| author | Zha, Kangkang Xiong, Yuan Zhang, Wenqian Tan, Meijun Hu, Weixian Lin, Ze Cheng, Peng Lu, Li Cai, Kaiyong Mi, Bobin Feng, Qian Zhao, Yanli Liu, Guohui |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Zha, Kangkang Xiong, Yuan Zhang, Wenqian Tan, Meijun Hu, Weixian Lin, Ze Cheng, Peng Lu, Li Cai, Kaiyong Mi, Bobin Feng, Qian Zhao, Yanli Liu, Guohui |
| author_sort | Zha, Kangkang |
| collection | NTU |
| description | The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack of biological activity. Humic acids (HAs) show photothermal activity and can be used as a photosensitizer for photothermal therapy. In the presence of various functional groups, HAs are endowed with anti-inflammatory and antioxidant activities. The solubility of HAs is dependent on the pH value, which is soluble in neutral to alkaline conditions and undergoes a conformational change to a coiled and compact structure in acidic conditions. Additionally, Cu2+ is an emerging therapeutic agent for cutaneous wounds and can be chelated by HAs to form complexes. In this study, we explore the ability of HAs to modulate the inflammatory response, particularly macrophage polarization, and the potential underlying mechanism. We fabricate a near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded with SEW2871 (SEW), a macrophage recruitment agent, to treat bacteria-infected cutaneous wounds. The results show that HAs could promote M2 macrophage polarization in a dose-dependent manner. The Cu-HAs NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing. |
| first_indexed | 2025-02-19T03:49:28Z |
| format | Journal Article |
| id | ntu-10356/171282 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:49:28Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1712822023-10-18T04:27:56Z Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing Zha, Kangkang Xiong, Yuan Zhang, Wenqian Tan, Meijun Hu, Weixian Lin, Ze Cheng, Peng Lu, Li Cai, Kaiyong Mi, Bobin Feng, Qian Zhao, Yanli Liu, Guohui School of Chemistry, Chemical Engineering and Biotechnology Engineering::Chemical engineering Angiogenesis Humic Acids The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack of biological activity. Humic acids (HAs) show photothermal activity and can be used as a photosensitizer for photothermal therapy. In the presence of various functional groups, HAs are endowed with anti-inflammatory and antioxidant activities. The solubility of HAs is dependent on the pH value, which is soluble in neutral to alkaline conditions and undergoes a conformational change to a coiled and compact structure in acidic conditions. Additionally, Cu2+ is an emerging therapeutic agent for cutaneous wounds and can be chelated by HAs to form complexes. In this study, we explore the ability of HAs to modulate the inflammatory response, particularly macrophage polarization, and the potential underlying mechanism. We fabricate a near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded with SEW2871 (SEW), a macrophage recruitment agent, to treat bacteria-infected cutaneous wounds. The results show that HAs could promote M2 macrophage polarization in a dose-dependent manner. The Cu-HAs NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing. This work was supported by the National Science Foundation of China (82272491, 82072444, and 82202714), the Department of Science and Technology (2020BCB004), the People’s Republic of China Ministry of Education Science and Technology Development Center (2021JH027), and the China Postdoctoral Science Foundation (2021TQ0118). 2023-10-18T04:27:56Z 2023-10-18T04:27:56Z 2023 Journal Article Zha, K., Xiong, Y., Zhang, W., Tan, M., Hu, W., Lin, Z., Cheng, P., Lu, L., Cai, K., Mi, B., Feng, Q., Zhao, Y. & Liu, G. (2023). Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing. ACS Nano, 17(17), 17199-17216. https://dx.doi.org/10.1021/acsnano.3c05075 1936-0851 https://hdl.handle.net/10356/171282 10.1021/acsnano.3c05075 37624642 2-s2.0-85170291985 17 17 17199 17216 en ACS Nano © 2023 American Chemical Society. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Angiogenesis Humic Acids Zha, Kangkang Xiong, Yuan Zhang, Wenqian Tan, Meijun Hu, Weixian Lin, Ze Cheng, Peng Lu, Li Cai, Kaiyong Mi, Bobin Feng, Qian Zhao, Yanli Liu, Guohui Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing |
| title | Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing |
| title_full | Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing |
| title_fullStr | Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing |
| title_full_unstemmed | Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing |
| title_short | Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing |
| title_sort | waste to wealth near infrared ph dual responsive copper humic acid hydrogel films for bacteria infected cutaneous wound healing |
| topic | Engineering::Chemical engineering Angiogenesis Humic Acids |
| url | https://hdl.handle.net/10356/171282 |
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