EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

Human airway and corneal epithelial cells, which are critically altered during chronic infections mediated by Pseudomonas aeruginosa, specifically express the inflammasome sensor NLRP1. Here, together with a companion study, we report that the NLRP1 inflammasome detects exotoxin A (EXOA), a ribotoxi...

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Detaylı Bibliyografya
Asıl Yazarlar: Pinilla, Miriam, Mazars, Raoul, Vergé, Romain, Gorse, Leana, Paradis, Margaux, Suire, Bastien, Santoni, Karin, Robinson, Kim Samirah, Toh, Gee Ann, Prouvensier, Laure, Leon-Icaza, Stephen Adonai, Hessel, Audrey, Péricat, David, Murris, Marlène, Guet-Revillet, Hélène, Henras, Anthony, Buyck, Julien, Ravet, Emmanuel, Zhong, Franklin, Cougoule, Céline, Planès, Rémi, Meunier, Etienne
Diğer Yazarlar: Lee Kong Chian School of Medicine (LKCMedicine)
Materyal Türü: Journal Article
Dil:English
Baskı/Yayın Bilgisi: 2023
Konular:
Science::Medicine
Elongation Factor 2
Inflammasome
Online Erişim:https://hdl.handle.net/10356/171557

Internet

https://hdl.handle.net/10356/171557

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