Single-input polarization-sensitive optical coherence tomography through a catheter
Intravascular polarimetry with catheter-based polarization-sensitive optical coherence tomography (PS-OCT) complements the high-resolution structural tomograms of OCT with morphological contrast available through polarimetry. Its clinical translation has been complicated by the need for modification...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/171572 |
| _version_ | 1824455282598608896 |
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| author | Jones, Georgia L. Xiong, Qiaozhou Liu, Xinyu Bouma, Brett E. Villiger, Martin |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Jones, Georgia L. Xiong, Qiaozhou Liu, Xinyu Bouma, Brett E. Villiger, Martin |
| author_sort | Jones, Georgia L. |
| collection | NTU |
| description | Intravascular polarimetry with catheter-based polarization-sensitive optical coherence tomography (PS-OCT) complements the high-resolution structural tomograms of OCT with morphological contrast available through polarimetry. Its clinical translation has been complicated by the need for modification of conventional OCT hardware to enable polarimetric measurements. Here, we present a signal processing method to reconstruct the polarization properties of tissue from measurements with a single input polarization state, bypassing the need for modulation or multiplexing of input states. Our method relies on a polarization symmetry intrinsic to round-trip measurements and uses the residual spectral variation of the polarization states incident on the tissue to avoid measurement ambiguities. We demonstrate depth-resolved birefringence and optic axis orientation maps reconstructed from in-vivo data of human coronary arteries. We validate our method through comparison with conventional dual-input state measurements and find a mean cumulative retardance error of 13.2deg without observable bias. The 95% limit of agreement between depth-resolved birefringence is 2.80 · 10-4, which is less than the agreement between two repeat pullbacks of conventional PS-OCT (3.14 · 10-4), indicating that the two methods can be used interchangeably. The hardware simplification arising from using a single input state may be decisive in realizing the potential of polarimetric measurements for assessing coronary atherosclerosis in clinical practice. |
| first_indexed | 2025-02-19T03:35:44Z |
| format | Journal Article |
| id | ntu-10356/171572 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:35:44Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1715722023-11-03T15:41:08Z Single-input polarization-sensitive optical coherence tomography through a catheter Jones, Georgia L. Xiong, Qiaozhou Liu, Xinyu Bouma, Brett E. Villiger, Martin School of Electrical and Electronic Engineering Science::Medicine Mode Dispersion Signal Processing Intravascular polarimetry with catheter-based polarization-sensitive optical coherence tomography (PS-OCT) complements the high-resolution structural tomograms of OCT with morphological contrast available through polarimetry. Its clinical translation has been complicated by the need for modification of conventional OCT hardware to enable polarimetric measurements. Here, we present a signal processing method to reconstruct the polarization properties of tissue from measurements with a single input polarization state, bypassing the need for modulation or multiplexing of input states. Our method relies on a polarization symmetry intrinsic to round-trip measurements and uses the residual spectral variation of the polarization states incident on the tissue to avoid measurement ambiguities. We demonstrate depth-resolved birefringence and optic axis orientation maps reconstructed from in-vivo data of human coronary arteries. We validate our method through comparison with conventional dual-input state measurements and find a mean cumulative retardance error of 13.2deg without observable bias. The 95% limit of agreement between depth-resolved birefringence is 2.80 · 10-4, which is less than the agreement between two repeat pullbacks of conventional PS-OCT (3.14 · 10-4), indicating that the two methods can be used interchangeably. The hardware simplification arising from using a single input state may be decisive in realizing the potential of polarimetric measurements for assessing coronary atherosclerosis in clinical practice. Published version This work was funded by National Institute of Biomedical Imaging and Bioengineering (P41EB- 015903, R01EB- 033321); Takeda Pharmaceuticals U.S.A. (MIT-Takeda Fellowship); Terumo Corporation (Sponsored Research Agreement). 2023-10-31T02:52:13Z 2023-10-31T02:52:13Z 2023 Journal Article Jones, G. L., Xiong, Q., Liu, X., Bouma, B. E. & Villiger, M. (2023). Single-input polarization-sensitive optical coherence tomography through a catheter. Biomedical Optics Express, 14(9), 4609-4626. https://dx.doi.org/10.1364/BOE.497123 2156-7085 https://hdl.handle.net/10356/171572 10.1364/BOE.497123 37791262 2-s2.0-85171271254 9 14 4609 4626 en Biomedical Optics Express © 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement. application/pdf |
| spellingShingle | Science::Medicine Mode Dispersion Signal Processing Jones, Georgia L. Xiong, Qiaozhou Liu, Xinyu Bouma, Brett E. Villiger, Martin Single-input polarization-sensitive optical coherence tomography through a catheter |
| title | Single-input polarization-sensitive optical coherence tomography through a catheter |
| title_full | Single-input polarization-sensitive optical coherence tomography through a catheter |
| title_fullStr | Single-input polarization-sensitive optical coherence tomography through a catheter |
| title_full_unstemmed | Single-input polarization-sensitive optical coherence tomography through a catheter |
| title_short | Single-input polarization-sensitive optical coherence tomography through a catheter |
| title_sort | single input polarization sensitive optical coherence tomography through a catheter |
| topic | Science::Medicine Mode Dispersion Signal Processing |
| url | https://hdl.handle.net/10356/171572 |
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