The modulatory role of cannabis use in subconcussive neural injury
Cannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed to test whether chronic cannabis use would be neuroprotective or exacerbating against acute subconcussive head impacts. This trial included 43 adult soccer players (Cannabis gr...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/171642 |
| _version_ | 1811684576910639104 |
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| author | Kalbfell, Rachel M. Rettke, Devin J. Mackie, Ken Ejima, Keisuke Harezlak, Jaroslaw Alexander, Isabella L. Wager-Miller, Jim Johnson, Blair D. Newman, Sharlene D. Kawata, Keisuke |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Kalbfell, Rachel M. Rettke, Devin J. Mackie, Ken Ejima, Keisuke Harezlak, Jaroslaw Alexander, Isabella L. Wager-Miller, Jim Johnson, Blair D. Newman, Sharlene D. Kawata, Keisuke |
| author_sort | Kalbfell, Rachel M. |
| collection | NTU |
| description | Cannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed to test whether chronic cannabis use would be neuroprotective or exacerbating against acute subconcussive head impacts. This trial included 43 adult soccer players (Cannabis group using cannabis at least once a week for the past 6 months, n = 24; non-cannabis control group, n = 19). Twenty soccer headings, induced by our controlled heading model, significantly impaired ocular-motor function, but the degrees of impairments were less in the cannabis group compared to controls. The control group significantly increased its serum S100B level after heading, whereas no change was observed in the cannabis group. There was no group difference in serum neurofilament light levels at any time point. Our data suggest that chronic cannabis use may be associated with an enhancement of oculomotor functional resiliency and suppression of the neuroinflammatory response following 20 soccer headings. |
| first_indexed | 2024-10-01T04:30:50Z |
| format | Journal Article |
| id | ntu-10356/171642 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:30:50Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1716422023-11-05T15:39:25Z The modulatory role of cannabis use in subconcussive neural injury Kalbfell, Rachel M. Rettke, Devin J. Mackie, Ken Ejima, Keisuke Harezlak, Jaroslaw Alexander, Isabella L. Wager-Miller, Jim Johnson, Blair D. Newman, Sharlene D. Kawata, Keisuke Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Traumatic Brain-injury Serum Neurofilament Light Cannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed to test whether chronic cannabis use would be neuroprotective or exacerbating against acute subconcussive head impacts. This trial included 43 adult soccer players (Cannabis group using cannabis at least once a week for the past 6 months, n = 24; non-cannabis control group, n = 19). Twenty soccer headings, induced by our controlled heading model, significantly impaired ocular-motor function, but the degrees of impairments were less in the cannabis group compared to controls. The control group significantly increased its serum S100B level after heading, whereas no change was observed in the cannabis group. There was no group difference in serum neurofilament light levels at any time point. Our data suggest that chronic cannabis use may be associated with an enhancement of oculomotor functional resiliency and suppression of the neuroinflammatory response following 20 soccer headings. Published version This work was partly supported by the Research Funds from the Indiana University Office of Vice President for Research (to K.K.), the National Institute of Neurological Disorders and Stroke (to K.K.: R01NS113950), and (to K.K. and S.N.: 1R21NS116548). 2023-11-02T01:57:35Z 2023-11-02T01:57:35Z 2023 Journal Article Kalbfell, R. M., Rettke, D. J., Mackie, K., Ejima, K., Harezlak, J., Alexander, I. L., Wager-Miller, J., Johnson, B. D., Newman, S. D. & Kawata, K. (2023). The modulatory role of cannabis use in subconcussive neural injury. IScience, 26(6), 106948-. https://dx.doi.org/10.1016/j.isci.2023.106948 2589-0042 https://hdl.handle.net/10356/171642 10.1016/j.isci.2023.106948 37332596 2-s2.0-85163332939 6 26 106948 en iScience © 2023 The Author(s). This is an open-access article distributed under the terms of the Creative Commons License. application/pdf |
| spellingShingle | Science::Medicine Traumatic Brain-injury Serum Neurofilament Light Kalbfell, Rachel M. Rettke, Devin J. Mackie, Ken Ejima, Keisuke Harezlak, Jaroslaw Alexander, Isabella L. Wager-Miller, Jim Johnson, Blair D. Newman, Sharlene D. Kawata, Keisuke The modulatory role of cannabis use in subconcussive neural injury |
| title | The modulatory role of cannabis use in subconcussive neural injury |
| title_full | The modulatory role of cannabis use in subconcussive neural injury |
| title_fullStr | The modulatory role of cannabis use in subconcussive neural injury |
| title_full_unstemmed | The modulatory role of cannabis use in subconcussive neural injury |
| title_short | The modulatory role of cannabis use in subconcussive neural injury |
| title_sort | modulatory role of cannabis use in subconcussive neural injury |
| topic | Science::Medicine Traumatic Brain-injury Serum Neurofilament Light |
| url | https://hdl.handle.net/10356/171642 |
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