Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels
People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual supernumerary chromosome-21 genes. The latter explan...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/171675 |
| _version_ | 1826117336027889664 |
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| author | Murray, Aoife Gough, Gillian Cindrić, Ana Vučković, Frano Koschut, David Borelli, Vincenzo Petrović, Dražen J. Bekavac, Ana Plećaš, Ante Hribljan, Valentina Brunmeir, Reinhard Jurić, Julija Pučić-Baković, Maja Slana, Anita Deriš, Helena Frkatović, Azra Groet, Jűrgen O'Brien, Niamh L. Chen, Hong Yu Yeap, Yee Jie Delom, Frederic Havlicek, Steven Gammon, Luke Hamburg, Sarah Startin, Carla D'Souza, Hana Mitrečić, Dinko Kero, Mijana Odak, Ljubica Krušlin, Božo Krsnik, Željka Kostović, Ivica Foo, Jia Nee Loh, Yuin-Han Dunn, Norris Ray de la Luna, Susana Spector, Tim Barišić, Ingeborg Thomas, Michael S. C. Strydom, Andre Franceschi, Claudio Lauc, Gordan Krištić, Jasminka Alić, Ivan Nizetic, Dean |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Murray, Aoife Gough, Gillian Cindrić, Ana Vučković, Frano Koschut, David Borelli, Vincenzo Petrović, Dražen J. Bekavac, Ana Plećaš, Ante Hribljan, Valentina Brunmeir, Reinhard Jurić, Julija Pučić-Baković, Maja Slana, Anita Deriš, Helena Frkatović, Azra Groet, Jűrgen O'Brien, Niamh L. Chen, Hong Yu Yeap, Yee Jie Delom, Frederic Havlicek, Steven Gammon, Luke Hamburg, Sarah Startin, Carla D'Souza, Hana Mitrečić, Dinko Kero, Mijana Odak, Ljubica Krušlin, Božo Krsnik, Željka Kostović, Ivica Foo, Jia Nee Loh, Yuin-Han Dunn, Norris Ray de la Luna, Susana Spector, Tim Barišić, Ingeborg Thomas, Michael S. C. Strydom, Andre Franceschi, Claudio Lauc, Gordan Krištić, Jasminka Alić, Ivan Nizetic, Dean |
| author_sort | Murray, Aoife |
| collection | NTU |
| description | People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual supernumerary chromosome-21 genes. The latter explanation could open a route to therapeutic amelioration if the specific over-acting genes could be identified and their action toned-down. |
| first_indexed | 2024-10-01T04:25:57Z |
| format | Journal Article |
| id | ntu-10356/171675 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:25:57Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1716752023-11-05T15:39:23Z Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels Murray, Aoife Gough, Gillian Cindrić, Ana Vučković, Frano Koschut, David Borelli, Vincenzo Petrović, Dražen J. Bekavac, Ana Plećaš, Ante Hribljan, Valentina Brunmeir, Reinhard Jurić, Julija Pučić-Baković, Maja Slana, Anita Deriš, Helena Frkatović, Azra Groet, Jűrgen O'Brien, Niamh L. Chen, Hong Yu Yeap, Yee Jie Delom, Frederic Havlicek, Steven Gammon, Luke Hamburg, Sarah Startin, Carla D'Souza, Hana Mitrečić, Dinko Kero, Mijana Odak, Ljubica Krušlin, Božo Krsnik, Željka Kostović, Ivica Foo, Jia Nee Loh, Yuin-Han Dunn, Norris Ray de la Luna, Susana Spector, Tim Barišić, Ingeborg Thomas, Michael S. C. Strydom, Andre Franceschi, Claudio Lauc, Gordan Krištić, Jasminka Alić, Ivan Nizetic, Dean Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Down Syndrome Ageing People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual supernumerary chromosome-21 genes. The latter explanation could open a route to therapeutic amelioration if the specific over-acting genes could be identified and their action toned-down. Ministry of Education (MOE) Ministry of Health (MOH) Published version This work has been supported by the “Research Cooperability” Program of the Croatian Science Foundation funded by the European Union from the European Social Fund under the Operational Programme Efficient Human Resources 2014–2020, Project PZS-2019-02-4277 (to GL and DN). This work has been also supported in part by the European Structural and Investment funding for the ‘Croatian National Centre of Research Excellence in Personalized Healthcare’, contract #KK.01.1.1.01.0010 (to GL); ‘Centre of Competences in Molecular Diagnostics’, contract #KK.01.2.2.03.0006 (to GL); the European Regional Development Fund grant ‘CardioMetabolic’ agreement #KK.01.2.1.02.0321 (to GL). DN was also funded by the Singapore Ministry of Education Academic Research Fund Tier 2 grants (2015-T2- 1-023 & 2015-T2-2-119) and the Wellcome Trust Collaborative Award in Science 217199/Z/19/Z. The teams of AStr, MT and DN also received funding from the Wellcome Trust “LonDownS Consortium” Strategic Funding Award (098330/Z/12/Z) (UK). In addition, AStr was supported by funding from the MRC (Medical Research Council grants MRC S011277/1, MR/S005145/1 (from Centers of Excellence in Neurodegeneration research) and MR/R024901/1 (from JPND). This work was also supported by Waterloo Foundation and Baily Thomas Charitable Fund (to MT). AM was awarded a William Harvey Academy Fellowship, co-funded by the People Programme (Marie Curie Actions) under REA no. 608765. IA was awarded an Adris Foundation grant (251-61-01/139- 22-01). The work of doctoral student HD has been supported by the “Young researchers’ career development project—training of doctoral students” of the Croatian Science Foundation. DM was supported by the Croatian Science Foundation project Orastem (IP-16-6-9451) and the European Union through the European Regional Development Fund, as the Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience under Grant Agreement No. KK.01.1.1.01.0007. JNF received funding from the National Medical Research Council, Singapore (MOH-000559). SdlL received funding from a Spanish Ministry of Science and Innovation grant PID2019-107185GB-I00. 2023-11-03T08:19:14Z 2023-11-03T08:19:14Z 2023 Journal Article Murray, A., Gough, G., Cindrić, A., Vučković, F., Koschut, D., Borelli, V., Petrović, D. J., Bekavac, A., Plećaš, A., Hribljan, V., Brunmeir, R., Jurić, J., Pučić-Baković, M., Slana, A., Deriš, H., Frkatović, A., Groet, J., O'Brien, N. L., Chen, H. Y., ...Nizetic, D. (2023). Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels. EBioMedicine, 94, 104692-. https://dx.doi.org/10.1016/j.ebiom.2023.104692 2352-3964 https://hdl.handle.net/10356/171675 10.1016/j.ebiom.2023.104692 37451904 2-s2.0-85166983572 94 104692 en 2015-T2- 1-023 2015-T2-2-119 MOH-000559 EBioMedicine © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Down Syndrome Ageing Murray, Aoife Gough, Gillian Cindrić, Ana Vučković, Frano Koschut, David Borelli, Vincenzo Petrović, Dražen J. Bekavac, Ana Plećaš, Ante Hribljan, Valentina Brunmeir, Reinhard Jurić, Julija Pučić-Baković, Maja Slana, Anita Deriš, Helena Frkatović, Azra Groet, Jűrgen O'Brien, Niamh L. Chen, Hong Yu Yeap, Yee Jie Delom, Frederic Havlicek, Steven Gammon, Luke Hamburg, Sarah Startin, Carla D'Souza, Hana Mitrečić, Dinko Kero, Mijana Odak, Ljubica Krušlin, Božo Krsnik, Željka Kostović, Ivica Foo, Jia Nee Loh, Yuin-Han Dunn, Norris Ray de la Luna, Susana Spector, Tim Barišić, Ingeborg Thomas, Michael S. C. Strydom, Andre Franceschi, Claudio Lauc, Gordan Krištić, Jasminka Alić, Ivan Nizetic, Dean Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels |
| title | Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels |
| title_full | Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels |
| title_fullStr | Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels |
| title_full_unstemmed | Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels |
| title_short | Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels |
| title_sort | dose imbalance of dyrk1a kinase causes systemic progeroid status in down syndrome by increasing the un repaired dna damage and reducing laminb1 levels |
| topic | Science::Medicine Down Syndrome Ageing |
| url | https://hdl.handle.net/10356/171675 |
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