Stability studies of ALD-52 and its homologue 1P-LSD
With the emergence of new psychoactive substances (NPSs) over the years, the substances detected on stamps (also known as blotter papers) have also evolved from the traditional drug-lysergic acid diethylamide (LSD) to the multiple variants of lysergamides such as ALD-52 and 1P-LSD. The analysis of s...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/171787 |
| _version_ | 1811685731362406400 |
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| author | Zhang, Shu-Hua Tang, Angeline S. Y. Chin, Reenie S. L. Goh, Jia Ying Ong, Mei Ching Lim, Wendy J. L. Yap, Angeline T. W. So, Cheuk-Wai |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Zhang, Shu-Hua Tang, Angeline S. Y. Chin, Reenie S. L. Goh, Jia Ying Ong, Mei Ching Lim, Wendy J. L. Yap, Angeline T. W. So, Cheuk-Wai |
| author_sort | Zhang, Shu-Hua |
| collection | NTU |
| description | With the emergence of new psychoactive substances (NPSs) over the years, the substances detected on stamps (also known as blotter papers) have also evolved from the traditional drug-lysergic acid diethylamide (LSD) to the multiple variants of lysergamides such as ALD-52 and 1P-LSD. The analysis of such blotter papers is usually done by solvent extraction followed by identification using gas chromatography-mass spectrometry (GC-MS). This study has shown that hydrolysis to form LSD was observed in GC-MS analysis when ALD-52 was extracted with methanol. The extraction of ALD-52 using other solvents such as acetonitrile, ethanol, isopropyl alcohol, ethyl acetate, and acetone, followed by GC-MS analysis, was investigated. It is shown that alcoholic solvents such as methanol and ethanol will result in the conversion of ALD-52 to LSD during GC-MS analysis, whereas the sterically hindered isopropyl alcohol will prevent this conversion. Investigation also shows that the hydrolysis of ALD-52 to LSD occurs at the GC injector port. It was also observed that the degree of hydrolysis was more pronounced at a lower concentration (0.1 mg/mL). The study was extended to a close analog-1P-LSD, and the results showed that 1P-LSD similarly hydrolyzes to LSD. However, 1P-LSD was observed to be more stable than ALD-52 due to steric hindrance because of the propanoyl group. |
| first_indexed | 2024-10-01T04:49:11Z |
| format | Journal Article |
| id | ntu-10356/171787 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:49:11Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1717872023-11-08T01:46:45Z Stability studies of ALD-52 and its homologue 1P-LSD Zhang, Shu-Hua Tang, Angeline S. Y. Chin, Reenie S. L. Goh, Jia Ying Ong, Mei Ching Lim, Wendy J. L. Yap, Angeline T. W. So, Cheuk-Wai School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry 1P-LSD ALD-52 With the emergence of new psychoactive substances (NPSs) over the years, the substances detected on stamps (also known as blotter papers) have also evolved from the traditional drug-lysergic acid diethylamide (LSD) to the multiple variants of lysergamides such as ALD-52 and 1P-LSD. The analysis of such blotter papers is usually done by solvent extraction followed by identification using gas chromatography-mass spectrometry (GC-MS). This study has shown that hydrolysis to form LSD was observed in GC-MS analysis when ALD-52 was extracted with methanol. The extraction of ALD-52 using other solvents such as acetonitrile, ethanol, isopropyl alcohol, ethyl acetate, and acetone, followed by GC-MS analysis, was investigated. It is shown that alcoholic solvents such as methanol and ethanol will result in the conversion of ALD-52 to LSD during GC-MS analysis, whereas the sterically hindered isopropyl alcohol will prevent this conversion. Investigation also shows that the hydrolysis of ALD-52 to LSD occurs at the GC injector port. It was also observed that the degree of hydrolysis was more pronounced at a lower concentration (0.1 mg/mL). The study was extended to a close analog-1P-LSD, and the results showed that 1P-LSD similarly hydrolyzes to LSD. However, 1P-LSD was observed to be more stable than ALD-52 due to steric hindrance because of the propanoyl group. 2023-11-08T01:46:45Z 2023-11-08T01:46:45Z 2023 Journal Article Zhang, S., Tang, A. S. Y., Chin, R. S. L., Goh, J. Y., Ong, M. C., Lim, W. J. L., Yap, A. T. W. & So, C. (2023). Stability studies of ALD-52 and its homologue 1P-LSD. Journal of Forensic Sciences, 68(3), 1009-1019. https://dx.doi.org/10.1111/1556-4029.15224 0022-1198 https://hdl.handle.net/10356/171787 10.1111/1556-4029.15224 36779453 2-s2.0-85148005529 3 68 1009 1019 en Journal of Forensic Sciences © 2023 American Academy of Forensic Sciences. All rights reserved. |
| spellingShingle | Science::Chemistry 1P-LSD ALD-52 Zhang, Shu-Hua Tang, Angeline S. Y. Chin, Reenie S. L. Goh, Jia Ying Ong, Mei Ching Lim, Wendy J. L. Yap, Angeline T. W. So, Cheuk-Wai Stability studies of ALD-52 and its homologue 1P-LSD |
| title | Stability studies of ALD-52 and its homologue 1P-LSD |
| title_full | Stability studies of ALD-52 and its homologue 1P-LSD |
| title_fullStr | Stability studies of ALD-52 and its homologue 1P-LSD |
| title_full_unstemmed | Stability studies of ALD-52 and its homologue 1P-LSD |
| title_short | Stability studies of ALD-52 and its homologue 1P-LSD |
| title_sort | stability studies of ald 52 and its homologue 1p lsd |
| topic | Science::Chemistry 1P-LSD ALD-52 |
| url | https://hdl.handle.net/10356/171787 |
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