Characterization of scaffold library to build scaffolds for bones and cartilages
The use of Computer Aided System for Tissue Scaffold (CASTS) which is an auxiliary platform developed for Pro/ENGINEER to fabricate scaffolds satisfies the need for a system to generate scaffolds of complex designs in order to customize the scaffold according to the patient s specifications. 13 d...
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| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/10356/17194 |
| _version_ | 1826124472799723520 |
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| author | Wan Mohd Firdaus Wan Ahmad |
| author2 | Leong Kah Fai |
| author_facet | Leong Kah Fai Wan Mohd Firdaus Wan Ahmad |
| author_sort | Wan Mohd Firdaus Wan Ahmad |
| collection | NTU |
| description | The use of Computer Aided System for Tissue Scaffold (CASTS) which is an auxiliary
platform developed for Pro/ENGINEER to fabricate scaffolds satisfies the need for a system
to generate scaffolds of complex designs in order to customize the scaffold according to the
patient s specifications. 13 different configurations from a range of polyhedral shapes were
available for selection.
Due to its complexity, scaffolds were fabricated using Selective Laser Sintering (SLS)
technology, which is a Solid Free Form (SFF) technique. The human is bone is layered with
functional gradients to satisfy the one or more specific functions that it has to perform.
Hence, functional gradients were also utilized in scaffolds to satisfy the biological,
anatomical and mechanical requirements of bone [2]. The application of functional gradients
were employed in the scaffolds ensures proper transfer of nutrients and prevent the
delamination of the scaffold interface.
Scaffolds designed using CASTS consist of cells which can be individually tailored to attain
specific pore sizes or porosity. As such, the ASTM standard D1621-04a: Standard Test
Method for the Compressive Properties of Cellular Solids was adopted to attain the
compressive stiffness for mechanical characterization. These scaffolds were fabricated using
polycaprolactone (PCL) and the introduction of 10% weight of hydroxyapatite (HA) which
is a major constituent of bone, improves cell adhesion and the mechanical properties of
scaffolds. Specimens were sent for compression using the Instron Universal 5569 at a strain
rate of 2.5 mm/s at up to 0.06 strain.
ii
It was found that the PCL-HA 10% scaffolds of 40% porosity fabricated using CASTS have
a compressive stiffness value of 1-104 MPa while the 60% and the 80% scaffolds have a
range of 10-29 MPa and 0.9-6.2 MPa respectively. The design of PCL-HA 10% scaffolds
using Configuration 10 was found to be suitable for the replication of the human mandibular
bone as it was within the desired compressive stiffness range and its simplicity in generating
functional gradients. |
| first_indexed | 2024-10-01T06:21:13Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/17194 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:21:13Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/171942023-03-04T18:24:57Z Characterization of scaffold library to build scaffolds for bones and cartilages Wan Mohd Firdaus Wan Ahmad Leong Kah Fai School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering The use of Computer Aided System for Tissue Scaffold (CASTS) which is an auxiliary platform developed for Pro/ENGINEER to fabricate scaffolds satisfies the need for a system to generate scaffolds of complex designs in order to customize the scaffold according to the patient s specifications. 13 different configurations from a range of polyhedral shapes were available for selection. Due to its complexity, scaffolds were fabricated using Selective Laser Sintering (SLS) technology, which is a Solid Free Form (SFF) technique. The human is bone is layered with functional gradients to satisfy the one or more specific functions that it has to perform. Hence, functional gradients were also utilized in scaffolds to satisfy the biological, anatomical and mechanical requirements of bone [2]. The application of functional gradients were employed in the scaffolds ensures proper transfer of nutrients and prevent the delamination of the scaffold interface. Scaffolds designed using CASTS consist of cells which can be individually tailored to attain specific pore sizes or porosity. As such, the ASTM standard D1621-04a: Standard Test Method for the Compressive Properties of Cellular Solids was adopted to attain the compressive stiffness for mechanical characterization. These scaffolds were fabricated using polycaprolactone (PCL) and the introduction of 10% weight of hydroxyapatite (HA) which is a major constituent of bone, improves cell adhesion and the mechanical properties of scaffolds. Specimens were sent for compression using the Instron Universal 5569 at a strain rate of 2.5 mm/s at up to 0.06 strain. ii It was found that the PCL-HA 10% scaffolds of 40% porosity fabricated using CASTS have a compressive stiffness value of 1-104 MPa while the 60% and the 80% scaffolds have a range of 10-29 MPa and 0.9-6.2 MPa respectively. The design of PCL-HA 10% scaffolds using Configuration 10 was found to be suitable for the replication of the human mandibular bone as it was within the desired compressive stiffness range and its simplicity in generating functional gradients. Bachelor of Engineering (Mechanical Engineering) 2009-06-01T06:24:58Z 2009-06-01T06:24:58Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/17194 en Nanyang Technological University 93 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Bioengineering Wan Mohd Firdaus Wan Ahmad Characterization of scaffold library to build scaffolds for bones and cartilages |
| title | Characterization of scaffold library to build scaffolds for bones and cartilages |
| title_full | Characterization of scaffold library to build scaffolds for bones and cartilages |
| title_fullStr | Characterization of scaffold library to build scaffolds for bones and cartilages |
| title_full_unstemmed | Characterization of scaffold library to build scaffolds for bones and cartilages |
| title_short | Characterization of scaffold library to build scaffolds for bones and cartilages |
| title_sort | characterization of scaffold library to build scaffolds for bones and cartilages |
| topic | DRNTU::Engineering::Bioengineering |
| url | http://hdl.handle.net/10356/17194 |
| work_keys_str_mv | AT wanmohdfirdauswanahmad characterizationofscaffoldlibrarytobuildscaffoldsforbonesandcartilages |