Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance between RBC formation (erythropoiesis) and removal. The splenic RBC retention and elimination occur predominantly in open circulation where RBCs flow through macrophages and inter-endothelial slits (IESs)....

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Bibliographic Details
Main Authors: Qiang, Yuhao, Sissoko, Abdoulaye, Liu, Zixiang L., Dong, Ting, Zheng, Fuyin, Kong, Fang, Higgins, John M., Karniadakis, George E., Buffet, Pierre A., Suresh, Subra, Dao, Ming
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
Hypoxia
Acute Splenic Sequestration Crisis
Online Access:https://hdl.handle.net/10356/172028

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