Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan
Background: Few studies have explored the role of body composition linking air pollution to obstructive sleep apnea (OSA). Objective: To estimate the effects of air pollution on body composition and OSA, and that of body composition on OSA. Methods: This study included 3550 individuals. A spatiotemp...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/172066 |
| _version_ | 1826109837118799872 |
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| author | He, Yansu Liu, Wen-Te Lin, Shang-Yang Li, Zhiyuan Qiu, Hong Yim, Steve Hung Lam Chuang, Hsiao-Chi Ho, Kin Fai |
| author2 | Asian School of the Environment |
| author_facet | Asian School of the Environment He, Yansu Liu, Wen-Te Lin, Shang-Yang Li, Zhiyuan Qiu, Hong Yim, Steve Hung Lam Chuang, Hsiao-Chi Ho, Kin Fai |
| author_sort | He, Yansu |
| collection | NTU |
| description | Background: Few studies have explored the role of body composition linking air pollution to obstructive sleep apnea (OSA). Objective: To estimate the effects of air pollution on body composition and OSA, and that of body composition on OSA. Methods: This study included 3550 individuals. A spatiotemporal model estimated personal exposure. Nocturnal changes in body composition were assessed through bioelectric impedance analysis. OSA was diagnosed using polysomnography. A generalized linear model was used to evaluate the absolute nocturnal changes in body composition associated with an interquartile range (IQR) increase in pollutants. A generalized logistic model was used to estimate odds ratios (ORs) of mild-OSA compared to non-OSA. Association between body composition and apnea–hypopnea index (AHI) was investigated through partial least squares (PLS) regression. Results: Nocturnal changes in lower-limb body composition were associated with NO2 and PM2.5 in all patients. In participants with AHI <15, both short- and long-term NO2 exposures affected body composition and mild-OSA, while PM2.5 was not associated with either outcome. In a PLS model incorporating eight NO2-associated lower-limb parameters, the variable importance projection scores (VIP) of left leg impedance (LLIMP), predicted muscle mass (LLPMM), fat-free mass (LLFFM), and right leg impedance (RLIMP) exceeded 1; the corresponding coefficients ranked in the top four for AHI prediction. The adjusted OR (mild vs. non-OSA) was 1.67 (95 % CI: 1.36–2.03) associated with an IQR increase in prediction value estimated from body compositions. Notably, the two-pollutant model investigating the effects of pollutants on body compositions revealed associations of four parameters (LLIMP, LLPMM, LLFFM, and RLIMP) with NO2 in all lags, which indicates their indispensability in the association between NO2 and AHI. Conclusions: NO2 exacerbates mild-OSA by disrupting nocturnal changes in lower-limb body composition of patients with AHI <15. PM2.5 was associated with nocturnal changes in lower-limb body composition but not with mild-OSA. |
| first_indexed | 2024-10-01T02:24:55Z |
| format | Journal Article |
| id | ntu-10356/172066 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:24:55Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1720662023-11-21T02:57:02Z Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan He, Yansu Liu, Wen-Te Lin, Shang-Yang Li, Zhiyuan Qiu, Hong Yim, Steve Hung Lam Chuang, Hsiao-Chi Ho, Kin Fai Asian School of the Environment Engineering::Environmental engineering::Environmental pollution Spatiotemporal Model Polysomnography Background: Few studies have explored the role of body composition linking air pollution to obstructive sleep apnea (OSA). Objective: To estimate the effects of air pollution on body composition and OSA, and that of body composition on OSA. Methods: This study included 3550 individuals. A spatiotemporal model estimated personal exposure. Nocturnal changes in body composition were assessed through bioelectric impedance analysis. OSA was diagnosed using polysomnography. A generalized linear model was used to evaluate the absolute nocturnal changes in body composition associated with an interquartile range (IQR) increase in pollutants. A generalized logistic model was used to estimate odds ratios (ORs) of mild-OSA compared to non-OSA. Association between body composition and apnea–hypopnea index (AHI) was investigated through partial least squares (PLS) regression. Results: Nocturnal changes in lower-limb body composition were associated with NO2 and PM2.5 in all patients. In participants with AHI <15, both short- and long-term NO2 exposures affected body composition and mild-OSA, while PM2.5 was not associated with either outcome. In a PLS model incorporating eight NO2-associated lower-limb parameters, the variable importance projection scores (VIP) of left leg impedance (LLIMP), predicted muscle mass (LLPMM), fat-free mass (LLFFM), and right leg impedance (RLIMP) exceeded 1; the corresponding coefficients ranked in the top four for AHI prediction. The adjusted OR (mild vs. non-OSA) was 1.67 (95 % CI: 1.36–2.03) associated with an IQR increase in prediction value estimated from body compositions. Notably, the two-pollutant model investigating the effects of pollutants on body compositions revealed associations of four parameters (LLIMP, LLPMM, LLFFM, and RLIMP) with NO2 in all lags, which indicates their indispensability in the association between NO2 and AHI. Conclusions: NO2 exacerbates mild-OSA by disrupting nocturnal changes in lower-limb body composition of patients with AHI <15. PM2.5 was associated with nocturnal changes in lower-limb body composition but not with mild-OSA. This study was supported by the Vice-Chancellors Discretionary Fund of The Chinese University of Hong Kong (project no.: 4930744). 2023-11-21T02:57:02Z 2023-11-21T02:57:02Z 2023 Journal Article He, Y., Liu, W., Lin, S., Li, Z., Qiu, H., Yim, S. H. L., Chuang, H. & Ho, K. F. (2023). Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan. Science of the Total Environment, 887, 163969-. https://dx.doi.org/10.1016/j.scitotenv.2023.163969 0048-9697 https://hdl.handle.net/10356/172066 10.1016/j.scitotenv.2023.163969 37164092 2-s2.0-85159376724 887 163969 en Science of the Total Environment © 2023 Elsevier B.V. All rights reserved. |
| spellingShingle | Engineering::Environmental engineering::Environmental pollution Spatiotemporal Model Polysomnography He, Yansu Liu, Wen-Te Lin, Shang-Yang Li, Zhiyuan Qiu, Hong Yim, Steve Hung Lam Chuang, Hsiao-Chi Ho, Kin Fai Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan |
| title | Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan |
| title_full | Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan |
| title_fullStr | Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan |
| title_full_unstemmed | Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan |
| title_short | Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: a cross-sectional study conducted in urban northern Taiwan |
| title_sort | air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower limb body composition a cross sectional study conducted in urban northern taiwan |
| topic | Engineering::Environmental engineering::Environmental pollution Spatiotemporal Model Polysomnography |
| url | https://hdl.handle.net/10356/172066 |
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