APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia
White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs furth...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/172169 |
| _version_ | 1811677792100679680 |
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| author | Vipin, Ashwati Kumar, Dilip Soo, See Ann Zailan, Fatin Zahra Leow, Yi Jin Koh, Chen Ling Ng, Adeline Su Lyn Ng, Kok Pin Kandiah, Nagaendran |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Vipin, Ashwati Kumar, Dilip Soo, See Ann Zailan, Fatin Zahra Leow, Yi Jin Koh, Chen Ling Ng, Adeline Su Lyn Ng, Kok Pin Kandiah, Nagaendran |
| author_sort | Vipin, Ashwati |
| collection | NTU |
| description | White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs further exploration. |
| first_indexed | 2024-10-01T02:42:59Z |
| format | Journal Article |
| id | ntu-10356/172169 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:42:59Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1721692023-12-03T15:38:23Z APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia Vipin, Ashwati Kumar, Dilip Soo, See Ann Zailan, Fatin Zahra Leow, Yi Jin Koh, Chen Ling Ng, Adeline Su Lyn Ng, Kok Pin Kandiah, Nagaendran Lee Kong Chian School of Medicine (LKCMedicine) Dementia Research Centre Science::Medicine White Matter Hyperintensity Dementia White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs further exploration. Ministry of Education (MOE) Nanyang Technological University National Medical Research Council (NMRC) Published version This study is supported by the Ministry of Education, Singapore, under its MOE AcRF Tier 3 Award MOE2017-T3-1–002, National Medical Research Council (NMRC/CIRG/1415/2015 and NMRC/CSA/063/2014), Singapore, and under its Clinician Scientist Award (MOH-CSAINV18nov-0007) and Clinician Scientist Individual Research Grant (NMRC/CIRG/14MAY025), Strategic Academic Initiative grant from the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, and National Neuroscience Institute-Health Research Endowment Fund (NNI-HREF), Singapore (Reference Number: 991016). 2023-11-28T05:17:48Z 2023-11-28T05:17:48Z 2023 Journal Article Vipin, A., Kumar, D., Soo, S. A., Zailan, F. Z., Leow, Y. J., Koh, C. L., Ng, A. S. L., Ng, K. P. & Kandiah, N. (2023). APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia. Alzheimer's Research & Therapy, 15(1), 103-. https://dx.doi.org/10.1186/s13195-023-01251-4 1758-9193 https://hdl.handle.net/10356/172169 10.1186/s13195-023-01251-4 37270543 2-s2.0-85160904159 1 15 103 en MOE2017-T3-1–002 NMRC/CIRG/1415/2015 NMRC/CSA/063/2014 MOH-CSAINV18nov-0007 NMRC/CIRG/14MAY025 NNI-HREF-991016 Alzheimer's Research & Therapy © 2023 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
| spellingShingle | Science::Medicine White Matter Hyperintensity Dementia Vipin, Ashwati Kumar, Dilip Soo, See Ann Zailan, Fatin Zahra Leow, Yi Jin Koh, Chen Ling Ng, Adeline Su Lyn Ng, Kok Pin Kandiah, Nagaendran APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia |
| title | APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia |
| title_full | APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia |
| title_fullStr | APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia |
| title_full_unstemmed | APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia |
| title_short | APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia |
| title_sort | apoe4 carrier status determines association between white matter disease and grey matter atrophy in early stage dementia |
| topic | Science::Medicine White Matter Hyperintensity Dementia |
| url | https://hdl.handle.net/10356/172169 |
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