Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia

Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia

We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. They were stratified into A+N+, A- N+, and A- N- profiles via cerebrospinal fluid amyloid-β1-42 (A), phosphorylated-tau...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran
अन्य लेखक:	Lee Kong Chian School of Medicine (LKCMedicine)
स्वरूप:	Journal Article
भाषा:	English
प्रकाशित:	2023
विषय:	Science::Medicine Cognition Longitudinal
ऑनलाइन पहुंच:	https://hdl.handle.net/10356/172174

समान संसाधन

Upregulated blood miR-150-5p in alzheimer's disease dementia is associated with cognition, cerebrospinal fluid amyloid-β, and cerebral atrophy
द्वारा: Chia, Sook Yoong, और अन्य
प्रकाशित: (2023)

APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia
द्वारा: Vipin, Ashwati, और अन्य
प्रकाशित: (2023)

Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional
द्वारा: Vipin, Ashwati, और अन्य
प्रकाशित: (2021)

Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
द्वारा: Vipin, Ashwati, और अन्य
प्रकाशित: (2022)

Impact of diabetes on the progression of Alzheimer’s disease via trajectories of amyloid–tau–neurodegeneration (ATN) biomarkers
द्वारा: Eun Woo Kim, और अन्य
प्रकाशित: (2025-02-01)

High diagnostic utility incorporating a targeted neurodegeneration gene panel with MRI brain diagnostic algorithms in patients with young-onset cognitive impairment with leukodystrophy
द्वारा: Chen, Zhiyong, और अन्य
प्रकाशित: (2021)

Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study
द्वारा: Jori Tomassen, और अन्य
प्रकाशित: (2022-01-01)

Beyond neurodegeneration: engineering amyloids for biocatalysis
द्वारा: Andrea Bartolomé-Nafría, और अन्य
प्रकाशित: (2025-10-01)

Tau as a fluid biomarker of concussion and neurodegeneration
द्वारा: Iftakher Hossain, और अन्य
प्रकाशित: (2022-12-01)

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
द्वारा: Dias-Santagata, D, और अन्य
प्रकाशित: (2007)

Membrane-induced tau amyloid fibrils
द्वारा: El Mammeri, Nadia, और अन्य
प्रकाशित: (2024)

Normative data for baseline and longitudinal neuropsychological assessments in Singapore
द्वारा: Wilbur Zhi Hao Koh, और अन्य
प्रकाशित: (2024-01-01)

Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration
द्वारा: Tan, Chin Hong, और अन्य
प्रकाशित: (2020)

Screening for Familial APP Mutations in Sporadic Cerebral Amyloid Angiopathy
द्वारा: Biffi, Alessandro, और अन्य
प्रकाशित: (2011)

Tau Protein and β-Amyloid Associated with Neurodegeneration in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis (EAE), a Mouse Model of Multiple Sclerosis
द्वारा: Grażyna Pyka-Fościak, और अन्य
प्रकाशित: (2024-12-01)

The role of perfusion, grey matter volume and behavioural phenotypes in the data-driven classification of cognitive syndromes
द्वारा: Vipin, Ashwati, और अन्य
प्रकाशित: (2024)

Regulation of Tau gene expression by Aβ and the amyloid precursosr protein in cultured cortical neurons
द्वारा: Yang, Benson P. (Benson Pin-Sheng)
प्रकाशित: (2009)

Target tau, not amyloid, to prevent and treat Alzheimer’s disease
द्वारा: Esiri, MM
प्रकाशित: (2020)

Development of curcumin based probe for tau and amyloid imaging
द्वारा: Satnam Singh
प्रकाशित: (2018)

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
द्वारा: Kanae Iijima-Ando, और अन्य
प्रकाशित: (2012-01-01)

Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects
द्वारा: Francisco Martínez-Dubarbie, और अन्य
प्रकाशित: (2024-12-01)

Utility of left atrial and ventricular strain for diagnosis of transthyretin amyloid cardiomyopathy in aortic stenosis
द्वारा: Fumi Oike, और अन्य
प्रकाशित: (2022-06-01)

Measurement of neurodegeneration using a multivariate early frame amyloid PET classifier
द्वारा: Dawn C. Matthews, और अन्य
प्रकाशित: (2022-01-01)

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries
द्वारा: Lim, Levinia, और अन्य
प्रकाशित: (2018)

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.
द्वारा: Santa-Maria, I, और अन्य
प्रकाशित: (2015)

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
द्वारा: Carsten Merkwirth, और अन्य
प्रकाशित: (2012-01-01)

Prediction of rapid amyloid and phospotylated-tau accumulation in cognitively healthy individuals
द्वारा: Koychev, I, और अन्य
प्रकाशित: (2020)

Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer’s Disease Therapeutics
द्वारा: Daniela Dias, और अन्य
प्रकाशित: (2025-01-01)

Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
द्वारा: Mario Nizzari, और अन्य
प्रकाशित: (2012-01-01)

Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
द्वारा: Kamath, Tarun(Tarun Vinod)
प्रकाशित: (2020)

Mild behavioral impairment and cerebrovascular profiles are associated with early cognitive impairment in a community-based Southeast Asian cohort
द्वारा: Leow, Yi Jin, और अन्य
प्रकाशित: (2024)

Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease
द्वारा: Guoqiao Wang, और अन्य
प्रकाशित: (2022-01-01)

Correlation of Alzheimer’s Disease neuropathologic staging with amyloid and tau scintigraphic imaging biomarkers
द्वारा: Koychev, I, और अन्य
प्रकाशित: (2020)

Molecular mechanisms at the basis of the protective effect exerted by EPPS on neurodegeneration induced by prefibrillar amyloid oligomers
द्वारा: Beatrice Zarrilli, और अन्य
प्रकाशित: (2024-11-01)

Resilience in Crisis: A Longitudinal Study of Entrepreneurial Responses to COVID-19 pandemic
द्वारा: Yi Zhang, और अन्य
प्रकाशित: (2024-12-01)

Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients
द्वारा: Hyuk Sung Kwon, और अन्य
प्रकाशित: (2025-03-01)

Topology of diffusion changes in corpus callosum in Alzheimer's disease: an exploratory case-control study
द्वारा: Kumar, Sumeet, और अन्य
प्रकाशित: (2023)

C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort
द्वारा: Tan, Yi Jayne, और अन्य
प्रकाशित: (2023)

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
द्वारा: Shipton, O, और अन्य
प्रकाशित: (2011)

Distribution of β-amyloid and pTau in brain cortex depending on age and mental state
द्वारा: Alexandra V. Sentyabreva, और अन्य
प्रकाशित: (2024-12-01)