Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia

Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia

We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. They were stratified into A+N+, A- N+, and A- N- profiles via cerebrospinal fluid amyloid-β1-42 (A), phosphorylated-tau...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran
Kolejni autorzy:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Journal Article
Język:	English
Wydane:	2023
Hasła przedmiotowe:	Science::Medicine Cognition Longitudinal
Dostęp online:	https://hdl.handle.net/10356/172174

Podobne zapisy

Upregulated blood miR-150-5p in alzheimer's disease dementia is associated with cognition, cerebrospinal fluid amyloid-β, and cerebral atrophy
od: Chia, Sook Yoong, i wsp.
Wydane: (2023)

APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia
od: Vipin, Ashwati, i wsp.
Wydane: (2023)

Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional
od: Vipin, Ashwati, i wsp.
Wydane: (2021)

Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
od: Vipin, Ashwati, i wsp.
Wydane: (2022)

Impact of diabetes on the progression of Alzheimer’s disease via trajectories of amyloid–tau–neurodegeneration (ATN) biomarkers
od: Eun Woo Kim, i wsp.
Wydane: (2025-02-01)

High diagnostic utility incorporating a targeted neurodegeneration gene panel with MRI brain diagnostic algorithms in patients with young-onset cognitive impairment with leukodystrophy
od: Chen, Zhiyong, i wsp.
Wydane: (2021)

Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study
od: Jori Tomassen, i wsp.
Wydane: (2022-01-01)

Beyond neurodegeneration: engineering amyloids for biocatalysis
od: Andrea Bartolomé-Nafría, i wsp.
Wydane: (2025-10-01)

Tau as a fluid biomarker of concussion and neurodegeneration
od: Iftakher Hossain, i wsp.
Wydane: (2022-12-01)

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
od: Dias-Santagata, D, i wsp.
Wydane: (2007)

Membrane-induced tau amyloid fibrils
od: El Mammeri, Nadia, i wsp.
Wydane: (2024)

Normative data for baseline and longitudinal neuropsychological assessments in Singapore
od: Wilbur Zhi Hao Koh, i wsp.
Wydane: (2024-01-01)

Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration
od: Tan, Chin Hong, i wsp.
Wydane: (2020)

Screening for Familial APP Mutations in Sporadic Cerebral Amyloid Angiopathy
od: Biffi, Alessandro, i wsp.
Wydane: (2011)

Tau Protein and β-Amyloid Associated with Neurodegeneration in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis (EAE), a Mouse Model of Multiple Sclerosis
od: Grażyna Pyka-Fościak, i wsp.
Wydane: (2024-12-01)

The role of perfusion, grey matter volume and behavioural phenotypes in the data-driven classification of cognitive syndromes
od: Vipin, Ashwati, i wsp.
Wydane: (2024)

Regulation of Tau gene expression by Aβ and the amyloid precursosr protein in cultured cortical neurons
od: Yang, Benson P. (Benson Pin-Sheng)
Wydane: (2009)

Target tau, not amyloid, to prevent and treat Alzheimer’s disease
od: Esiri, MM
Wydane: (2020)

Development of curcumin based probe for tau and amyloid imaging
od: Satnam Singh
Wydane: (2018)

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
od: Kanae Iijima-Ando, i wsp.
Wydane: (2012-01-01)

Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects
od: Francisco Martínez-Dubarbie, i wsp.
Wydane: (2024-12-01)

Utility of left atrial and ventricular strain for diagnosis of transthyretin amyloid cardiomyopathy in aortic stenosis
od: Fumi Oike, i wsp.
Wydane: (2022-06-01)

Measurement of neurodegeneration using a multivariate early frame amyloid PET classifier
od: Dawn C. Matthews, i wsp.
Wydane: (2022-01-01)

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries
od: Lim, Levinia, i wsp.
Wydane: (2018)

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.
od: Santa-Maria, I, i wsp.
Wydane: (2015)

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
od: Carsten Merkwirth, i wsp.
Wydane: (2012-01-01)

Prediction of rapid amyloid and phospotylated-tau accumulation in cognitively healthy individuals
od: Koychev, I, i wsp.
Wydane: (2020)

Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer’s Disease Therapeutics
od: Daniela Dias, i wsp.
Wydane: (2025-01-01)

Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
od: Mario Nizzari, i wsp.
Wydane: (2012-01-01)

Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
od: Kamath, Tarun(Tarun Vinod)
Wydane: (2020)

Mild behavioral impairment and cerebrovascular profiles are associated with early cognitive impairment in a community-based Southeast Asian cohort
od: Leow, Yi Jin, i wsp.
Wydane: (2024)

Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease
od: Guoqiao Wang, i wsp.
Wydane: (2022-01-01)

Correlation of Alzheimer’s Disease neuropathologic staging with amyloid and tau scintigraphic imaging biomarkers
od: Koychev, I, i wsp.
Wydane: (2020)

Molecular mechanisms at the basis of the protective effect exerted by EPPS on neurodegeneration induced by prefibrillar amyloid oligomers
od: Beatrice Zarrilli, i wsp.
Wydane: (2024-11-01)

Resilience in Crisis: A Longitudinal Study of Entrepreneurial Responses to COVID-19 pandemic
od: Yi Zhang, i wsp.
Wydane: (2024-12-01)

Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients
od: Hyuk Sung Kwon, i wsp.
Wydane: (2025-03-01)

Topology of diffusion changes in corpus callosum in Alzheimer's disease: an exploratory case-control study
od: Kumar, Sumeet, i wsp.
Wydane: (2023)

C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort
od: Tan, Yi Jayne, i wsp.
Wydane: (2023)

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
od: Shipton, O, i wsp.
Wydane: (2011)

Distribution of β-amyloid and pTau in brain cortex depending on age and mental state
od: Alexandra V. Sentyabreva, i wsp.
Wydane: (2024-12-01)