Nanosized silica particles for achiral drug separation
It is widely recognized that the full potential of rapid chromatography can be realized with very small support particulates and tailor-made chiral stationary phase. However, there has been limited open publication in this area. This work reports the use of a novel monodispersed porous nanosized sil...
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| Format: | Research Report |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/10356/17219 |
| _version_ | 1824456353755693056 |
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| author | Tan, Timothy Thatt Yang. |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Tan, Timothy Thatt Yang. |
| author_sort | Tan, Timothy Thatt Yang. |
| collection | NTU |
| description | It is widely recognized that the full potential of rapid chromatography can be realized with very small support particulates and tailor-made chiral stationary phase. However, there has been limited open publication in this area. This work reports the use of a novel monodispersed porous nanosized silica column in UPLC application. In this work, we have demonstrated about 3 times enhanced separation using a C18 functionalized nanosilica column compared to a commercial column. The main objectives of the project are: (1) to synthesize and functionalize silica nanoparticles and (2) apply the nanosilica for achiral drug separation. A modified Stober method is used to synthesize the silica nanoparticle. The nanoparticles were then functionalized with octadecylsilane (C18). Achiral compounds were then separated using a Ultra Performance Liquid Chromatography (UPLC). |
| first_indexed | 2025-02-19T03:52:45Z |
| format | Research Report |
| id | ntu-10356/17219 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:52:45Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/172192023-03-03T15:30:51Z Nanosized silica particles for achiral drug separation Tan, Timothy Thatt Yang. School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biochemical engineering It is widely recognized that the full potential of rapid chromatography can be realized with very small support particulates and tailor-made chiral stationary phase. However, there has been limited open publication in this area. This work reports the use of a novel monodispersed porous nanosized silica column in UPLC application. In this work, we have demonstrated about 3 times enhanced separation using a C18 functionalized nanosilica column compared to a commercial column. The main objectives of the project are: (1) to synthesize and functionalize silica nanoparticles and (2) apply the nanosilica for achiral drug separation. A modified Stober method is used to synthesize the silica nanoparticle. The nanoparticles were then functionalized with octadecylsilane (C18). Achiral compounds were then separated using a Ultra Performance Liquid Chromatography (UPLC). RG 37/05 2009-06-01T08:44:48Z 2009-06-01T08:44:48Z 2005 2005 Research Report http://hdl.handle.net/10356/17219 en 11 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Chemical engineering::Biochemical engineering Tan, Timothy Thatt Yang. Nanosized silica particles for achiral drug separation |
| title | Nanosized silica particles for achiral drug separation |
| title_full | Nanosized silica particles for achiral drug separation |
| title_fullStr | Nanosized silica particles for achiral drug separation |
| title_full_unstemmed | Nanosized silica particles for achiral drug separation |
| title_short | Nanosized silica particles for achiral drug separation |
| title_sort | nanosized silica particles for achiral drug separation |
| topic | DRNTU::Engineering::Chemical engineering::Biochemical engineering |
| url | http://hdl.handle.net/10356/17219 |
| work_keys_str_mv | AT tantimothythattyang nanosizedsilicaparticlesforachiraldrugseparation |