Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study
The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/172279 |
| _version_ | 1811687813152768000 |
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| author | Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M. |
| author_sort | Chandran, Likha |
| collection | NTU |
| description | The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular level. On the other hand, 58S glass ceramic are suffers some extent to expedite the new bone formation. The incorporation of rare earth elements into the bioactive glass ceramic matrix significantly improved the new bone formation. In addition, the cytotoxicity and biocompatibility properties of the obtained ceramic powder were investigated in vitro and in vivo for bone graft efficiency. The results showed that the rare earth elements in bioactive glass ceramic have the potential to repair damaged hard tissues. |
| first_indexed | 2024-10-01T05:22:16Z |
| format | Journal Article |
| id | ntu-10356/172279 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:22:16Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1722792023-12-05T01:45:48Z Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M. Lee Kong Chian School of Medicine (LKCMedicine) Cognitive Neuroimaging Centre Science::Medicine 58S Bioglass Cytotoxicity The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular level. On the other hand, 58S glass ceramic are suffers some extent to expedite the new bone formation. The incorporation of rare earth elements into the bioactive glass ceramic matrix significantly improved the new bone formation. In addition, the cytotoxicity and biocompatibility properties of the obtained ceramic powder were investigated in vitro and in vivo for bone graft efficiency. The results showed that the rare earth elements in bioactive glass ceramic have the potential to repair damaged hard tissues. The authors gratefully acknowledge the financial support received from Indian Council of Medical research (ICMR), New Delhi, India, No. 35/14/2011-BMS, SRF-ICMR-No. 45/27/2019/NAN-BMS, RUSA 2.0- BEICH-No. BU/RUSA/BEICH/2019/52, and TNSCST-No. TNSCST/STP-PRG/AR/2018–2019. 2023-12-05T01:45:48Z 2023-12-05T01:45:48Z 2023 Journal Article Chandran, L., Marimuthu, A., Abimanyu, R., Padmanabhan, P., Thirumavalavan, M. & Ballamurugan, A. M. (2023). Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study. Materials Chemistry and Physics, 300, 127533-. https://dx.doi.org/10.1016/j.matchemphys.2023.127533 0254-0584 https://hdl.handle.net/10356/172279 10.1016/j.matchemphys.2023.127533 2-s2.0-85150029078 300 127533 en Materials Chemistry and Physics © 2023 Elsevier B.V. All rights reserved. |
| spellingShingle | Science::Medicine 58S Bioglass Cytotoxicity Chandran, Likha Marimuthu, Arumugam Abimanyu, Ravichandran Padmanabhan, Parasuraman Thirumavalavan, Munusamy Ballamurugan, Anbalagan M. Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study |
| title | Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study |
| title_full | Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study |
| title_fullStr | Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study |
| title_full_unstemmed | Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study |
| title_short | Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - an in vitro and in vivo study |
| title_sort | trivalent rare earth elements substitution in 58s bioactive glass matrix for bone repair applications an in vitro and in vivo study |
| topic | Science::Medicine 58S Bioglass Cytotoxicity |
| url | https://hdl.handle.net/10356/172279 |
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