Cell-biomaterial interactions
The primary goals of this project were achieved. This was an extention of AcRF Tier 2 project on Hemocompatibilization of Biopolymer Systems. In this supplemental project, we evaluated the uptake of nanomicells by blood cells. A method for assessing the update by flow cytometry was developed, Severa...
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| Format: | Research Report |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/10356/17228 |
| _version_ | 1826127786760208384 |
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| author | Subramanian Venkatraman. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Subramanian Venkatraman. |
| author_sort | Subramanian Venkatraman. |
| collection | NTU |
| description | The primary goals of this project were achieved. This was an extention of AcRF Tier 2 project on Hemocompatibilization of Biopolymer Systems. In this supplemental project, we evaluated the uptake of nanomicells by blood cells. A method for assessing the update by flow cytometry was developed, Several copolymers with differing amount of a hydrophillic block were synthesized, formulated into nanomecells, and their uptake by blood cells, particularly monocytes, was evaluated. It was found that the density of the hydrophilic block as well as its apatial configuration were important in determining the avoidance of update by monocytes. Such particles are termed "stealth" particles, and are useful as carriers for cancer drugs to sloid tumours. The work has led to 2 publications in peer-reviewed journals ( average IF of accepted publication =1.9), and 3 conference presentaions. |
| first_indexed | 2024-10-01T07:14:32Z |
| format | Research Report |
| id | ntu-10356/17228 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:14:32Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/172282023-07-08T06:39:59Z Cell-biomaterial interactions Subramanian Venkatraman. School of Materials Science & Engineering DRNTU::Engineering::Materials::Biomaterials The primary goals of this project were achieved. This was an extention of AcRF Tier 2 project on Hemocompatibilization of Biopolymer Systems. In this supplemental project, we evaluated the uptake of nanomicells by blood cells. A method for assessing the update by flow cytometry was developed, Several copolymers with differing amount of a hydrophillic block were synthesized, formulated into nanomecells, and their uptake by blood cells, particularly monocytes, was evaluated. It was found that the density of the hydrophilic block as well as its apatial configuration were important in determining the avoidance of update by monocytes. Such particles are termed "stealth" particles, and are useful as carriers for cancer drugs to sloid tumours. The work has led to 2 publications in peer-reviewed journals ( average IF of accepted publication =1.9), and 3 conference presentaions. RG 108/05 2009-06-01T09:23:13Z 2009-06-01T09:23:13Z 2007 2007 Research Report http://hdl.handle.net/10356/17228 en 89 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Biomaterials Subramanian Venkatraman. Cell-biomaterial interactions |
| title | Cell-biomaterial interactions |
| title_full | Cell-biomaterial interactions |
| title_fullStr | Cell-biomaterial interactions |
| title_full_unstemmed | Cell-biomaterial interactions |
| title_short | Cell-biomaterial interactions |
| title_sort | cell biomaterial interactions |
| topic | DRNTU::Engineering::Materials::Biomaterials |
| url | http://hdl.handle.net/10356/17228 |
| work_keys_str_mv | AT subramanianvenkatraman cellbiomaterialinteractions |