Emergence of cortical network motifs for short-term memory during learning
Learning of adaptive behaviors requires the refinement of coordinated activity across multiple brain regions. However, how neural communications develop during learning remains poorly understood. Here, using two-photon calcium imaging, we simultaneously recorded the activity of layer 2/3 excitatory...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/172997 |
| _version_ | 1811693791730466816 |
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| author | Chia, Xin Wei Tan, Jian Kwang Ang, Lee Fang Kamigaki, Tsukasa Makino, Hiroshi |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chia, Xin Wei Tan, Jian Kwang Ang, Lee Fang Kamigaki, Tsukasa Makino, Hiroshi |
| author_sort | Chia, Xin Wei |
| collection | NTU |
| description | Learning of adaptive behaviors requires the refinement of coordinated activity across multiple brain regions. However, how neural communications develop during learning remains poorly understood. Here, using two-photon calcium imaging, we simultaneously recorded the activity of layer 2/3 excitatory neurons in eight regions of the mouse dorsal cortex during learning of a delayed-response task. Across learning, while global functional connectivity became sparser, there emerged a subnetwork comprising of neurons in the anterior lateral motor cortex (ALM) and posterior parietal cortex (PPC). Neurons in this subnetwork shared a similar choice code during action preparation and formed recurrent functional connectivity across learning. Suppression of PPC activity disrupted choice selectivity in ALM and impaired task performance. Recurrent neural networks reconstructed from ALM activity revealed that PPC-ALM interactions rendered choice-related attractor dynamics more stable. Thus, learning constructs cortical network motifs by recruiting specific inter-areal communication channels to promote efficient and robust sensorimotor transformation. |
| first_indexed | 2024-10-01T06:57:18Z |
| format | Journal Article |
| id | ntu-10356/172997 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:57:18Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1729972024-01-14T15:38:57Z Emergence of cortical network motifs for short-term memory during learning Chia, Xin Wei Tan, Jian Kwang Ang, Lee Fang Kamigaki, Tsukasa Makino, Hiroshi Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Brain Cortex Short Term Memory Learning of adaptive behaviors requires the refinement of coordinated activity across multiple brain regions. However, how neural communications develop during learning remains poorly understood. Here, using two-photon calcium imaging, we simultaneously recorded the activity of layer 2/3 excitatory neurons in eight regions of the mouse dorsal cortex during learning of a delayed-response task. Across learning, while global functional connectivity became sparser, there emerged a subnetwork comprising of neurons in the anterior lateral motor cortex (ALM) and posterior parietal cortex (PPC). Neurons in this subnetwork shared a similar choice code during action preparation and formed recurrent functional connectivity across learning. Suppression of PPC activity disrupted choice selectivity in ALM and impaired task performance. Recurrent neural networks reconstructed from ALM activity revealed that PPC-ALM interactions rendered choice-related attractor dynamics more stable. Thus, learning constructs cortical network motifs by recruiting specific inter-areal communication channels to promote efficient and robust sensorimotor transformation. Ministry of Education (MOE) Nanyang Technological University Published version This work was supported by NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (HM), Nanyang Assistant Professorship from Nanyang Technological University (HM), Singapore Ministry of Education Academic Research Fund Tier 1 2018-T1-001-032 (HM) and RT11/19 (HM), Singapore Ministry of Education Academic Research Fund Tier 2 MOE2018-T2-1-021 (HM) and MOE-T2EP30222-0009 (HM) and Singapore Ministry of Education Academic Research Fund Tier 3 MOE2017-T3-1-002 (HM). 2024-01-08T06:13:42Z 2024-01-08T06:13:42Z 2023 Journal Article Chia, X. W., Tan, J. K., Ang, L. F., Kamigaki, T. & Makino, H. (2023). Emergence of cortical network motifs for short-term memory during learning. Nature Communications, 14(1), 6869-. https://dx.doi.org/10.1038/s41467-023-42609-4 2041-1723 https://hdl.handle.net/10356/172997 10.1038/s41467-023-42609-4 37898638 2-s2.0-85175197954 1 14 6869 en 2018-T1-001-032 RT11/19 MOE2018-T2-1-021 MOE-T2EP30222-0009 MOE2017-T3-1-002 Nature Communications © 2023 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. application/pdf |
| spellingShingle | Science::Medicine Brain Cortex Short Term Memory Chia, Xin Wei Tan, Jian Kwang Ang, Lee Fang Kamigaki, Tsukasa Makino, Hiroshi Emergence of cortical network motifs for short-term memory during learning |
| title | Emergence of cortical network motifs for short-term memory during learning |
| title_full | Emergence of cortical network motifs for short-term memory during learning |
| title_fullStr | Emergence of cortical network motifs for short-term memory during learning |
| title_full_unstemmed | Emergence of cortical network motifs for short-term memory during learning |
| title_short | Emergence of cortical network motifs for short-term memory during learning |
| title_sort | emergence of cortical network motifs for short term memory during learning |
| topic | Science::Medicine Brain Cortex Short Term Memory |
| url | https://hdl.handle.net/10356/172997 |
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