NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor
Human serum albumin (HSA) based drug delivery platforms that feature desirable biocompatibility and pharmacokinetic property are rapidly developed for tumor-targeted drug delivery. Even though various HSA-based platforms have been established, it is still of great significance to develop more effici...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/172998 |
| _version_ | 1811679238296698880 |
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| author | Shi, Zhaoqing Luo, Miaomiao Huang, Qili Ding, Chendi Wang, Wenyan Wu, Yinglong Luo, Jingjing Lin, Chuchu Chen, Ting Zeng, Xiaowei Mei, Lin Zhao, Yanli Chen, Hongzhong |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Shi, Zhaoqing Luo, Miaomiao Huang, Qili Ding, Chendi Wang, Wenyan Wu, Yinglong Luo, Jingjing Lin, Chuchu Chen, Ting Zeng, Xiaowei Mei, Lin Zhao, Yanli Chen, Hongzhong |
| author_sort | Shi, Zhaoqing |
| collection | NTU |
| description | Human serum albumin (HSA) based drug delivery platforms that feature desirable biocompatibility and pharmacokinetic property are rapidly developed for tumor-targeted drug delivery. Even though various HSA-based platforms have been established, it is still of great significance to develop more efficient preparation technology to broaden the therapeutic applications of HSA-based nano-carriers. Here we report a bridging strategy that unfastens HSA to polypeptide chains and subsequently crosslinks these chains by a bridge-like molecule (BPY-Mal2) to afford the HSA reassemblies formulation (BPY@HSA) with enhanced loading capacity, endowing the BPY@HSA with uniformed size, high photothermal efficacy, and favorable therapeutic features. Both in vitro and in vivo studies demonstrate that the BPY@HSA presents higher delivery efficacy and more prominent photothermal therapeutic performance than that of the conventionally prepared formulation. The feasibility in preparation, stability, high photothermal conversion efficacy, and biocompatibility of BPY@HSA may facilitate it as an efficient photothermal agents (PTAs) for tumor photothermal therapy (PTT). This work provides a facile strategy to enhance the loading capacity of HSA-based crosslinking platforms in order to improve delivery efficacy and therapeutic effect. |
| first_indexed | 2024-10-01T03:05:59Z |
| format | Journal Article |
| id | ntu-10356/172998 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:05:59Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1729982024-01-12T15:31:57Z NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor Shi, Zhaoqing Luo, Miaomiao Huang, Qili Ding, Chendi Wang, Wenyan Wu, Yinglong Luo, Jingjing Lin, Chuchu Chen, Ting Zeng, Xiaowei Mei, Lin Zhao, Yanli Chen, Hongzhong School of Chemistry, Chemical Engineering and Biotechnology Engineering::Bioengineering Photothermal Therapy Human Serum Albumin Human serum albumin (HSA) based drug delivery platforms that feature desirable biocompatibility and pharmacokinetic property are rapidly developed for tumor-targeted drug delivery. Even though various HSA-based platforms have been established, it is still of great significance to develop more efficient preparation technology to broaden the therapeutic applications of HSA-based nano-carriers. Here we report a bridging strategy that unfastens HSA to polypeptide chains and subsequently crosslinks these chains by a bridge-like molecule (BPY-Mal2) to afford the HSA reassemblies formulation (BPY@HSA) with enhanced loading capacity, endowing the BPY@HSA with uniformed size, high photothermal efficacy, and favorable therapeutic features. Both in vitro and in vivo studies demonstrate that the BPY@HSA presents higher delivery efficacy and more prominent photothermal therapeutic performance than that of the conventionally prepared formulation. The feasibility in preparation, stability, high photothermal conversion efficacy, and biocompatibility of BPY@HSA may facilitate it as an efficient photothermal agents (PTAs) for tumor photothermal therapy (PTT). This work provides a facile strategy to enhance the loading capacity of HSA-based crosslinking platforms in order to improve delivery efficacy and therapeutic effect. Published version We greatly acknowledge the financial support from the National Natural Science Foundation of China (32101065 to H. Chen and 82272154 to L. Mei), the start-up fund (BS2021001 to C. Ding) from Maoming People’s Hospital, the Guangdong Medical Science and Technology Research Fund (A2021213 to C. Ding), the Fundamental Research Funds for the Central Universities (2021-RC310-005 to L. Mei), the Tianjin Science Fund for Distinguished Young Scholars (22JCJQJC00120 to L. Mei), the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-058 and 2022-I2M2-003 to L. Mei), the Science and Technology Program of Tianjin City (the Basic Research Cooperation Special Foundation of Beijing Tianjin-Hebei Region, 22JCZXJC00060 to L. Mei), and the National Research Foundation Singapore under Its Competitive Research Programme (NRF-CRP26-2021-0002 to Y. Zhao). 2024-01-08T06:22:35Z 2024-01-08T06:22:35Z 2023 Journal Article Shi, Z., Luo, M., Huang, Q., Ding, C., Wang, W., Wu, Y., Luo, J., Lin, C., Chen, T., Zeng, X., Mei, L., Zhao, Y. & Chen, H. (2023). NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor. Nature Communications, 14(1), 6567-. https://dx.doi.org/10.1038/s41467-023-42399-9 2041-1723 https://hdl.handle.net/10356/172998 10.1038/s41467-023-42399-9 37848496 2-s2.0-85174452071 1 14 6567 en NRF-CRP26-2021-0002 Nature Communications © 2023 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/. application/pdf |
| spellingShingle | Engineering::Bioengineering Photothermal Therapy Human Serum Albumin Shi, Zhaoqing Luo, Miaomiao Huang, Qili Ding, Chendi Wang, Wenyan Wu, Yinglong Luo, Jingjing Lin, Chuchu Chen, Ting Zeng, Xiaowei Mei, Lin Zhao, Yanli Chen, Hongzhong NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| title | NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| title_full | NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| title_fullStr | NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| title_full_unstemmed | NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| title_short | NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| title_sort | nir dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor |
| topic | Engineering::Bioengineering Photothermal Therapy Human Serum Albumin |
| url | https://hdl.handle.net/10356/172998 |
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