Hot-electron dynamics mediated medical diagnosis and therapy
Surface plasmon resonance excitation significantly enhances the absorption of light and increases the generation of “hot” electrons, i.e., conducting electrons that are raised from their steady states to excited states. These excited electrons rapidly decay and equilibrate via radiative and nonradia...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/173512 |
| _version_ | 1826125818010533888 |
|---|---|
| author | Luo, Bing Wang, Wei Zhao, Yuxin Zhao, Yanli |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Luo, Bing Wang, Wei Zhao, Yuxin Zhao, Yanli |
| author_sort | Luo, Bing |
| collection | NTU |
| description | Surface plasmon resonance excitation significantly enhances the absorption of light and increases the generation of “hot” electrons, i.e., conducting electrons that are raised from their steady states to excited states. These excited electrons rapidly decay and equilibrate via radiative and nonradiative damping over several hundred femtoseconds. During the hot-electron dynamics, from their generation to the ultimate nonradiative decay, the electromagnetic field enhancement, hot electron density increase, and local heating effect are sequentially induced. Over the past decade, these physical phenomena have attracted considerable attention in the biomedical field, e.g., the rapid and accurate identification of biomolecules, precise synthesis and release of drugs, and elimination of tumors. This review highlights the recent developments in the application of hot-electron dynamics in medical diagnosis and therapy, particularly fully integrated device techniques with good application prospects. In addition, we discuss the latest experimental and theoretical studies of underlying mechanisms. From a practical standpoint, the pioneering modeling analyses and quantitative measurements in the extreme near field are summarized to illustrate the quantification of hot-electron dynamics. Finally, the prospects and remaining challenges associated with biomedical engineering based on hot-electron dynamics are presented. |
| first_indexed | 2024-10-01T06:42:53Z |
| format | Journal Article |
| id | ntu-10356/173512 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:42:53Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1735122024-02-09T15:31:35Z Hot-electron dynamics mediated medical diagnosis and therapy Luo, Bing Wang, Wei Zhao, Yuxin Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Chemistry Conducting Electrons Electron Dynamics Surface plasmon resonance excitation significantly enhances the absorption of light and increases the generation of “hot” electrons, i.e., conducting electrons that are raised from their steady states to excited states. These excited electrons rapidly decay and equilibrate via radiative and nonradiative damping over several hundred femtoseconds. During the hot-electron dynamics, from their generation to the ultimate nonradiative decay, the electromagnetic field enhancement, hot electron density increase, and local heating effect are sequentially induced. Over the past decade, these physical phenomena have attracted considerable attention in the biomedical field, e.g., the rapid and accurate identification of biomolecules, precise synthesis and release of drugs, and elimination of tumors. This review highlights the recent developments in the application of hot-electron dynamics in medical diagnosis and therapy, particularly fully integrated device techniques with good application prospects. In addition, we discuss the latest experimental and theoretical studies of underlying mechanisms. From a practical standpoint, the pioneering modeling analyses and quantitative measurements in the extreme near field are summarized to illustrate the quantification of hot-electron dynamics. Finally, the prospects and remaining challenges associated with biomedical engineering based on hot-electron dynamics are presented. Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version The authors gratefully acknowledge financial support from the National Natural Science Foundation of China (62074123 and 52106270), the PetroChina Innovation Foundation (2019D-5007-0410), the China Postdoctoral Science Foundation (2020M683472), the National Research Foundation Singapore under Its Competitive Research Programme (NRF-CRP26-2021-0002), and the Ministry of Education Singapore under the Research Centres of Excellence Scheme (Institute for Digital Molecular Analytics and Science). 2024-02-08T05:57:34Z 2024-02-08T05:57:34Z 2023 Journal Article Luo, B., Wang, W., Zhao, Y. & Zhao, Y. (2023). Hot-electron dynamics mediated medical diagnosis and therapy. Chemical Reviews, 123(17), 10808-10833. https://dx.doi.org/10.1021/acs.chemrev.3c00475 0009-2665 https://hdl.handle.net/10356/173512 10.1021/acs.chemrev.3c00475 17 123 10808 10833 en NRF-CRP26-2021-0002 Chemical Reviews © 2023 American Chemical Society. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1021/acs.chemrev.3c00475. application/pdf |
| spellingShingle | Chemistry Conducting Electrons Electron Dynamics Luo, Bing Wang, Wei Zhao, Yuxin Zhao, Yanli Hot-electron dynamics mediated medical diagnosis and therapy |
| title | Hot-electron dynamics mediated medical diagnosis and therapy |
| title_full | Hot-electron dynamics mediated medical diagnosis and therapy |
| title_fullStr | Hot-electron dynamics mediated medical diagnosis and therapy |
| title_full_unstemmed | Hot-electron dynamics mediated medical diagnosis and therapy |
| title_short | Hot-electron dynamics mediated medical diagnosis and therapy |
| title_sort | hot electron dynamics mediated medical diagnosis and therapy |
| topic | Chemistry Conducting Electrons Electron Dynamics |
| url | https://hdl.handle.net/10356/173512 |
| work_keys_str_mv | AT luobing hotelectrondynamicsmediatedmedicaldiagnosisandtherapy AT wangwei hotelectrondynamicsmediatedmedicaldiagnosisandtherapy AT zhaoyuxin hotelectrondynamicsmediatedmedicaldiagnosisandtherapy AT zhaoyanli hotelectrondynamicsmediatedmedicaldiagnosisandtherapy |