Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
Titanium-based alloys exhibit superior resistance to corrosion and biocompatibility in comparison to other alloys utilized for implant applications, such as stainless steel and cobalt-based alloys. Nonetheless, no completely inert metal is suitable for implantation in the human body, as aseptic loos...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/173678 |
| _version_ | 1826128288087539712 |
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| author | Lin, Yu-Chien Hu, Chih-Chien Nguyen, Thu-Trang Dhawan, Udesh Chou, Ching-Yi Lee, Yueh-Lien Yen, Hung-Wei Kuo, Yi-Jie Chung, Ren-Jei |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Lin, Yu-Chien Hu, Chih-Chien Nguyen, Thu-Trang Dhawan, Udesh Chou, Ching-Yi Lee, Yueh-Lien Yen, Hung-Wei Kuo, Yi-Jie Chung, Ren-Jei |
| author_sort | Lin, Yu-Chien |
| collection | NTU |
| description | Titanium-based alloys exhibit superior resistance to corrosion and biocompatibility in comparison to other alloys utilized for implant applications, such as stainless steel and cobalt-based alloys. Nonetheless, no completely inert metal is suitable for implantation in the human body, as aseptic loosening of the implant or the release of ions in the vicinity of the implant can result in inflammation and implant failure. Therefore, the primary objective of this study was to employ hydrogenated titanium 6-aluminum-4-vanadium (H–Ti6Al4V) alloy to reduce reactive oxygen species (ROS) and thereby achieve the function of regulating inflammatory signaling when employed as an implant. The Ti6Al4V alloy was successfully hydrogenated using a cathodic hydrogen-charging method. The H–Ti6Al4V alloy displayed a surface Young's modulus 33.97 ± 9.21 GPa similar to that of trabecular bone (∼22.3 GPa) and notably lower hardness (3.32 ± 0.62 GPa) than the Ti6Al4V alloy (21.79 ± 2.42 GPa). In vitro and in vivo investigations indicated that the H–Ti6Al4V alloy did not negatively affect bone-related cells and triggered minimal inflammatory responses in Sprague–Dawley rats. Moreover, reduced ROS production was observed around the H–Ti6Al4V alloys, confirming that hydrogenation could effectively counteract the ROS generated during cell metabolism and indirectly impede the inflammatory response around the prosthesis, thereby rendering it a promising metallic implant for the treatment of bone defects. |
| first_indexed | 2024-10-01T07:22:31Z |
| format | Journal Article |
| id | ntu-10356/173678 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:22:31Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1736782024-02-23T15:45:51Z Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants Lin, Yu-Chien Hu, Chih-Chien Nguyen, Thu-Trang Dhawan, Udesh Chou, Ching-Yi Lee, Yueh-Lien Yen, Hung-Wei Kuo, Yi-Jie Chung, Ren-Jei School of Materials Science and Engineering Engineering Orthopedic implants Electrochemical hydrogen storage Titanium-based alloys exhibit superior resistance to corrosion and biocompatibility in comparison to other alloys utilized for implant applications, such as stainless steel and cobalt-based alloys. Nonetheless, no completely inert metal is suitable for implantation in the human body, as aseptic loosening of the implant or the release of ions in the vicinity of the implant can result in inflammation and implant failure. Therefore, the primary objective of this study was to employ hydrogenated titanium 6-aluminum-4-vanadium (H–Ti6Al4V) alloy to reduce reactive oxygen species (ROS) and thereby achieve the function of regulating inflammatory signaling when employed as an implant. The Ti6Al4V alloy was successfully hydrogenated using a cathodic hydrogen-charging method. The H–Ti6Al4V alloy displayed a surface Young's modulus 33.97 ± 9.21 GPa similar to that of trabecular bone (∼22.3 GPa) and notably lower hardness (3.32 ± 0.62 GPa) than the Ti6Al4V alloy (21.79 ± 2.42 GPa). In vitro and in vivo investigations indicated that the H–Ti6Al4V alloy did not negatively affect bone-related cells and triggered minimal inflammatory responses in Sprague–Dawley rats. Moreover, reduced ROS production was observed around the H–Ti6Al4V alloys, confirming that hydrogenation could effectively counteract the ROS generated during cell metabolism and indirectly impede the inflammatory response around the prosthesis, thereby rendering it a promising metallic implant for the treatment of bone defects. Published version The authors are grateful for the financial support received from the National Science and Technology Council of Taiwan (MOST 108-2628-E−027-003-MY3; MOST 109-2224-E−002-002); and the National Taipei University of Technology and Chang Gung Memorial Hospital Joint Research Program (NTUT-CGMH-111-01 [CORPG3M0191]). 2024-02-21T08:10:39Z 2024-02-21T08:10:39Z 2024 Journal Article Lin, Y., Hu, C., Nguyen, T., Dhawan, U., Chou, C., Lee, Y., Yen, H., Kuo, Y. & Chung, R. (2024). Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants. Journal of Materials Research and Technology, 28, 1504-1513. https://dx.doi.org/10.1016/j.jmrt.2023.12.066 2238-7854 https://hdl.handle.net/10356/173678 10.1016/j.jmrt.2023.12.066 2-s2.0-85179884531 28 1504 1513 en Journal of Materials Research and Technology © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). application/pdf |
| spellingShingle | Engineering Orthopedic implants Electrochemical hydrogen storage Lin, Yu-Chien Hu, Chih-Chien Nguyen, Thu-Trang Dhawan, Udesh Chou, Ching-Yi Lee, Yueh-Lien Yen, Hung-Wei Kuo, Yi-Jie Chung, Ren-Jei Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants |
| title | Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants |
| title_full | Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants |
| title_fullStr | Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants |
| title_full_unstemmed | Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants |
| title_short | Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants |
| title_sort | study on surface hydrogenated ti6al4v alloy for orthopedic implants |
| topic | Engineering Orthopedic implants Electrochemical hydrogen storage |
| url | https://hdl.handle.net/10356/173678 |
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