Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology
Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly, in 2022, icaritin soft capsules were approved to reach the market for the treatment of hepatocellular carcinoma (HCC) by N...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/173721 |
| _version_ | 1826126840476991488 |
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| author | Lu, Yi Luo, Qiulan Jia, Xiaobin Tam, James P. Yang, Huan Shen, Yuping Li, Xin |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Lu, Yi Luo, Qiulan Jia, Xiaobin Tam, James P. Yang, Huan Shen, Yuping Li, Xin |
| author_sort | Lu, Yi |
| collection | NTU |
| description | Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly, in 2022, icaritin soft capsules were approved to reach the market for the treatment of hepatocellular carcinoma (HCC) by National Medical Products Administration (NMPA) of China. Moreover, recent studies demonstrate that icaritin can serve as immune-modulating agent to exert anti-tumor effects. Nonetheless, both production efficiency and clinical applications of epimedium flavonoids have been restrained because of their low content, poor bioavailability, and unfavorable in vivo delivery efficiency. Recently, various strategies, including enzyme engineering and nanotechnology, have been developed to increase productivity and activity, improve delivery efficiency, and enhance therapeutic effects of epimedium flavonoids. In this review, the structure-activity relationship of epimedium flavonoids is described. Then, enzymatic engineering strategies for increasing the productivity of highly active baohuoside I and icaritin are discussed. The nanomedicines for overcoming in vivo delivery barriers and improving therapeutic effects of various diseases are summarized. Finally, the challenges and an outlook on clinical translation of epimedium flavonoids are proposed. |
| first_indexed | 2024-10-01T06:59:17Z |
| format | Journal Article |
| id | ntu-10356/173721 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:59:17Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1737212024-02-26T15:32:28Z Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology Lu, Yi Luo, Qiulan Jia, Xiaobin Tam, James P. Yang, Huan Shen, Yuping Li, Xin School of Biological Sciences Medicine, Health and Life Sciences Flavonoids Enzymatic hydrolysis Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly, in 2022, icaritin soft capsules were approved to reach the market for the treatment of hepatocellular carcinoma (HCC) by National Medical Products Administration (NMPA) of China. Moreover, recent studies demonstrate that icaritin can serve as immune-modulating agent to exert anti-tumor effects. Nonetheless, both production efficiency and clinical applications of epimedium flavonoids have been restrained because of their low content, poor bioavailability, and unfavorable in vivo delivery efficiency. Recently, various strategies, including enzyme engineering and nanotechnology, have been developed to increase productivity and activity, improve delivery efficiency, and enhance therapeutic effects of epimedium flavonoids. In this review, the structure-activity relationship of epimedium flavonoids is described. Then, enzymatic engineering strategies for increasing the productivity of highly active baohuoside I and icaritin are discussed. The nanomedicines for overcoming in vivo delivery barriers and improving therapeutic effects of various diseases are summarized. Finally, the challenges and an outlook on clinical translation of epimedium flavonoids are proposed. Published version This work was supported by the National Natural Science Foundation of China (Grant No.: 81873196), Sino-German Center for Research Promotion (Project No.: GZ1505), Chinese Scholarship Council, and Science and Technology Planning Projects of Jiaxing City (Project No.: 2022AY10014). 2024-02-26T00:50:52Z 2024-02-26T00:50:52Z 2023 Journal Article Lu, Y., Luo, Q., Jia, X., Tam, J. P., Yang, H., Shen, Y. & Li, X. (2023). Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology. Journal of Pharmaceutical Analysis, 13(3), 239-254. https://dx.doi.org/10.1016/j.jpha.2022.12.001 2095-1779 https://hdl.handle.net/10356/173721 10.1016/j.jpha.2022.12.001 37102112 2-s2.0-85148256803 3 13 239 254 en Journal of Pharmaceutical Analysis © 2022 The Author(s). Published by Elsevier B.V. on behalf of Xi’an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Flavonoids Enzymatic hydrolysis Lu, Yi Luo, Qiulan Jia, Xiaobin Tam, James P. Yang, Huan Shen, Yuping Li, Xin Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology |
| title | Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology |
| title_full | Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology |
| title_fullStr | Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology |
| title_full_unstemmed | Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology |
| title_short | Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: integration of herbal medicine, enzyme engineering, and nanotechnology |
| title_sort | multidisciplinary strategies to enhance therapeutic effects of flavonoids from epimedii folium integration of herbal medicine enzyme engineering and nanotechnology |
| topic | Medicine, Health and Life Sciences Flavonoids Enzymatic hydrolysis |
| url | https://hdl.handle.net/10356/173721 |
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