Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes

Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes

A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild condition...

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Bibliographic Details
Main Authors: He, Yimiao, Yuan, Jingwen, Lv, Wen-Xin, Liu, Peng, Teng, Fan, Mo, Qijin, Wu, Zihua, Huang, Chusheng, Liu, Qianwen, Wang, Honggen
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Journal Article
Language:English
Published: 2024
Subjects:
Chemistry
Gem-difluorocyclopropene
Ring-opening defluorination
Online Access:https://hdl.handle.net/10356/173744
Description
Summary:A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents. Water plays a crucial role in this transformation.

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