Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave
Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-ris...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/173859 |
| _version_ | 1811693892800610304 |
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| author | Goh, Yun Shan Fong, Siew-Wai Tay, Matthew Zirui Rouers, Angeline Chang, Zi Wei Chavatte, Jean-Marc Hor, Pei Xiang Loh, Chiew Yee Huang, Yuling Tan, Yong Jie Wang, Bei Ngoh, Eve Zi Xian Siti Nazihah Mohd Salleh Lee, Raphael Tze Chuen Lim, Georgina Maurer-Stroh, Sebastian Wang, Cheng-I Leo, Yee-Sin Lin, Raymond T. P. Lam, Meng Chon Lye, David C. Young, Barnaby Edward Ng, Lisa F. P. Renia, Laurent |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Goh, Yun Shan Fong, Siew-Wai Tay, Matthew Zirui Rouers, Angeline Chang, Zi Wei Chavatte, Jean-Marc Hor, Pei Xiang Loh, Chiew Yee Huang, Yuling Tan, Yong Jie Wang, Bei Ngoh, Eve Zi Xian Siti Nazihah Mohd Salleh Lee, Raphael Tze Chuen Lim, Georgina Maurer-Stroh, Sebastian Wang, Cheng-I Leo, Yee-Sin Lin, Raymond T. P. Lam, Meng Chon Lye, David C. Young, Barnaby Edward Ng, Lisa F. P. Renia, Laurent |
| author_sort | Goh, Yun Shan |
| collection | NTU |
| description | Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-risk groups. In this study, we recruited 158 mRNA-vaccinated individuals during the Delta wave of SARS-CoV-2 infections in Singapore and examined the antibody profiles of infected individuals. We found that, despite high exposure due to communal living conditions in proximity, 4% of individuals (6/158) had PCR-confirmed infections and 96% (152/158) remained uninfected. Time-course analysis of the antibody profile at the start and the end of quarantine period showed Delta-specific boosting of anti-spike antibody response in 57% of the uninfected individuals (86/152). In the remaining 43% of the uninfected individuals (66/152) with no Delta-specific antibody boost, we found a higher Delta-specific antibody response at the start of quarantine period, which correlated with higher Delta pseudovirus neutralizing capacity. Our findings indicate that a higher basal variant-specific antibody response in the mRNA-vaccinated individuals contributes to better protection against infections by the new emerging SARS-CoV-2 variants. |
| first_indexed | 2024-10-01T06:58:54Z |
| format | Journal Article |
| id | ntu-10356/173859 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:58:54Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1738592024-03-10T15:37:56Z Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave Goh, Yun Shan Fong, Siew-Wai Tay, Matthew Zirui Rouers, Angeline Chang, Zi Wei Chavatte, Jean-Marc Hor, Pei Xiang Loh, Chiew Yee Huang, Yuling Tan, Yong Jie Wang, Bei Ngoh, Eve Zi Xian Siti Nazihah Mohd Salleh Lee, Raphael Tze Chuen Lim, Georgina Maurer-Stroh, Sebastian Wang, Cheng-I Leo, Yee-Sin Lin, Raymond T. P. Lam, Meng Chon Lye, David C. Young, Barnaby Edward Ng, Lisa F. P. Renia, Laurent Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Yong Loo Lin School of Medicine, NUS Tan Tock Seng Hospital Saw Swee Hock School of Public Health, NUS National Centre for Infectious Diseases A*STAR Infectious Diseases Labs Medicine, Health and Life Sciences SARS-CoV-2 Delta mRNA vaccines Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-risk groups. In this study, we recruited 158 mRNA-vaccinated individuals during the Delta wave of SARS-CoV-2 infections in Singapore and examined the antibody profiles of infected individuals. We found that, despite high exposure due to communal living conditions in proximity, 4% of individuals (6/158) had PCR-confirmed infections and 96% (152/158) remained uninfected. Time-course analysis of the antibody profile at the start and the end of quarantine period showed Delta-specific boosting of anti-spike antibody response in 57% of the uninfected individuals (86/152). In the remaining 43% of the uninfected individuals (66/152) with no Delta-specific antibody boost, we found a higher Delta-specific antibody response at the start of quarantine period, which correlated with higher Delta pseudovirus neutralizing capacity. Our findings indicate that a higher basal variant-specific antibody response in the mRNA-vaccinated individuals contributes to better protection against infections by the new emerging SARS-CoV-2 variants. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University National Medical Research Council (NMRC) Published version This work was supported by the Biomedical Research Council (BMRC), A*CRUSE (Vaccine monitoring project), the A*ccelerate GAP-funded project (ACCL/19-GAP064-R20H-H) from Agency of Science, Technology and Research (A*STAR), Singapore National Medical Research Council COVID-19 Research Fund (COVID19RF-0001; COVID19RF-007; COVID19RF-0008; COVID19RF-0011; COVID19RF-0060), US Food and Drug Administration (#75F40120C00085) and A*STAR COVID-19 Research funding (H/20/04/g1/006). YSG was supported by a Career Development Fund award by A*STAR (SC35/22-805100). LR was also supported by a Start-up University Grant from Nanyang Technological University. 2024-03-04T01:54:29Z 2024-03-04T01:54:29Z 2023 Journal Article Goh, Y. S., Fong, S., Tay, M. Z., Rouers, A., Chang, Z. W., Chavatte, J., Hor, P. X., Loh, C. Y., Huang, Y., Tan, Y. J., Wang, B., Ngoh, E. Z. X., Siti Nazihah Mohd Salleh, Lee, R. T. C., Lim, G., Maurer-Stroh, S., Wang, C., Leo, Y., Lin, R. T. P., ...Renia, L. (2023). Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave. Scientific Reports, 13(1), 19331-. https://dx.doi.org/10.1038/s41598-023-46800-x 2045-2322 https://hdl.handle.net/10356/173859 10.1038/s41598-023-46800-x 37935965 2-s2.0-85176112857 1 13 19331 en COVID19RF-0001 COVID19RF-007 COVID19RF-0008 COVID19RF-0011 COVID19RF-0060 H/20/04/g1/006 ACCL/19-GAP064-R20H-H Scientific Reports © The Author(s) 2023, corrected publication 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences SARS-CoV-2 Delta mRNA vaccines Goh, Yun Shan Fong, Siew-Wai Tay, Matthew Zirui Rouers, Angeline Chang, Zi Wei Chavatte, Jean-Marc Hor, Pei Xiang Loh, Chiew Yee Huang, Yuling Tan, Yong Jie Wang, Bei Ngoh, Eve Zi Xian Siti Nazihah Mohd Salleh Lee, Raphael Tze Chuen Lim, Georgina Maurer-Stroh, Sebastian Wang, Cheng-I Leo, Yee-Sin Lin, Raymond T. P. Lam, Meng Chon Lye, David C. Young, Barnaby Edward Ng, Lisa F. P. Renia, Laurent Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_full | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_fullStr | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_full_unstemmed | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_short | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_sort | higher delta variant specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mrna vaccines during the sars cov 2 delta wave |
| topic | Medicine, Health and Life Sciences SARS-CoV-2 Delta mRNA vaccines |
| url | https://hdl.handle.net/10356/173859 |
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