Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial
In view of the limited evidence showing anti-obesity effects of synbiotics via modulation of the gut microbiota in humans, a randomized clinical trial was performed. Assessment of the metabolic syndrome traits and profiling of the fecal gut microbiota using 16S rRNA gene sequencing in overweight and...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/174005 |
| _version_ | 1811679158971924480 |
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| author | Lauw, Susana Kei, Nelson Chan, Po Lam Yau, Tsz Kwan Ma, Ka Lee Szeto, Carol Ying Ying Lin, Janice Su-Chuen Wong, Sunny Hei Cheung, Peter Chi Keung Kwan, Hoi Shan |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Lauw, Susana Kei, Nelson Chan, Po Lam Yau, Tsz Kwan Ma, Ka Lee Szeto, Carol Ying Ying Lin, Janice Su-Chuen Wong, Sunny Hei Cheung, Peter Chi Keung Kwan, Hoi Shan |
| author_sort | Lauw, Susana |
| collection | NTU |
| description | In view of the limited evidence showing anti-obesity effects of synbiotics via modulation of the gut microbiota in humans, a randomized clinical trial was performed. Assessment of the metabolic syndrome traits and profiling of the fecal gut microbiota using 16S rRNA gene sequencing in overweight and obese Hong Kong Chinese individuals before and after dietary intervention with an 8-week increased consumption of fruits and vegetables and/or synbiotic supplementation was conducted. The selected synbiotic contained two probiotics (Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019) and a prebiotic (polydextrose). Fifty-five overweight or obese individuals were randomized and divided into a synbiotic group (SG; n = 19), a dietary intervention group (DG; n = 18), and a group receiving combined interventions (DSG; n = 18). DSG showed the greatest weight loss effects and number of significant differences in clinical parameters compared to its baseline values-notably, decreases in fasting glucose, insulin, HOMA-IR, and triglycerides and an increase in HDL-cholesterol. DSG lowered Megamonas abundance, which was positively associated with BMI, body fat mass, and trunk fat mass. The results suggested that increasing dietary fiber consumption from fruits and vegetables combined with synbiotic supplementation is more effective than either approach alone in tackling obesity. |
| first_indexed | 2024-10-01T03:04:43Z |
| format | Journal Article |
| id | ntu-10356/174005 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:04:43Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1740052024-03-17T15:38:19Z Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial Lauw, Susana Kei, Nelson Chan, Po Lam Yau, Tsz Kwan Ma, Ka Lee Szeto, Carol Ying Ying Lin, Janice Su-Chuen Wong, Sunny Hei Cheung, Peter Chi Keung Kwan, Hoi Shan Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Gut microbiota Gut health In view of the limited evidence showing anti-obesity effects of synbiotics via modulation of the gut microbiota in humans, a randomized clinical trial was performed. Assessment of the metabolic syndrome traits and profiling of the fecal gut microbiota using 16S rRNA gene sequencing in overweight and obese Hong Kong Chinese individuals before and after dietary intervention with an 8-week increased consumption of fruits and vegetables and/or synbiotic supplementation was conducted. The selected synbiotic contained two probiotics (Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019) and a prebiotic (polydextrose). Fifty-five overweight or obese individuals were randomized and divided into a synbiotic group (SG; n = 19), a dietary intervention group (DG; n = 18), and a group receiving combined interventions (DSG; n = 18). DSG showed the greatest weight loss effects and number of significant differences in clinical parameters compared to its baseline values-notably, decreases in fasting glucose, insulin, HOMA-IR, and triglycerides and an increase in HDL-cholesterol. DSG lowered Megamonas abundance, which was positively associated with BMI, body fat mass, and trunk fat mass. The results suggested that increasing dietary fiber consumption from fruits and vegetables combined with synbiotic supplementation is more effective than either approach alone in tackling obesity. Published version This research was partly funded by the Research Impact Fund (RGC reference no.: R5034- 18) provided by the Research Grants Council of Hong Kong SAR and by the internal research fund of the Food Research Centre of The Chinese University of Hong Kong. 2024-03-11T07:04:56Z 2024-03-11T07:04:56Z 2023 Journal Article Lauw, S., Kei, N., Chan, P. L., Yau, T. K., Ma, K. L., Szeto, C. Y. Y., Lin, J. S., Wong, S. H., Cheung, P. C. K. & Kwan, H. S. (2023). Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial. Nutrients, 15(19), 15194248-. https://dx.doi.org/10.3390/nu15194248 2072-6643 https://hdl.handle.net/10356/174005 10.3390/nu15194248 37836532 2-s2.0-85173857177 19 15 15194248 en Nutrients © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Gut microbiota Gut health Lauw, Susana Kei, Nelson Chan, Po Lam Yau, Tsz Kwan Ma, Ka Lee Szeto, Carol Ying Ying Lin, Janice Su-Chuen Wong, Sunny Hei Cheung, Peter Chi Keung Kwan, Hoi Shan Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial |
| title | Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial |
| title_full | Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial |
| title_fullStr | Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial |
| title_full_unstemmed | Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial |
| title_short | Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: a randomized trial |
| title_sort | effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese hong kong chinese individuals a randomized trial |
| topic | Medicine, Health and Life Sciences Gut microbiota Gut health |
| url | https://hdl.handle.net/10356/174005 |
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