Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive
Carbene based bioadhesives are developmental tissue adhesive, where photolysis creates carbenes that indiscriminately insert into amino acids. However, the nitrogen side product generates internal pores, creating a relatively weak cohesive matrix. To further improve cohesive toughness, photo-curing...
| Autori principali: | , |
|---|---|
| Altri autori: | |
| Natura: | Conference Paper |
| Lingua: | English |
| Pubblicazione: |
2024
|
| Soggetti: | |
| Accesso online: | https://hdl.handle.net/10356/174202 https://wbc2024.com/ |
| _version_ | 1826113887957680128 |
|---|---|
| author | Ang, Elwin Wei Jian Steele, Terry W. J. |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Ang, Elwin Wei Jian Steele, Terry W. J. |
| author_sort | Ang, Elwin Wei Jian |
| collection | NTU |
| description | Carbene based bioadhesives are developmental tissue adhesive, where photolysis creates carbenes that indiscriminately insert into amino acids. However, the nitrogen side product generates internal pores, creating a relatively weak cohesive matrix. To further improve cohesive toughness, photo-curing at elevated temperatures hypothesizes higher nitrogen solubility and lower apparent viscosity in order to generate higher crosslinking density. Real-time crosslinking kinetics of storage (G’) and loss (G”) moduli and adhesive properties post-activation (viscosity, yield stress and modulus of toughness) are characterised through a custom photorheometer setup with a high thermal-conductivity, temperature-controlled diamond plate. Dual activation improved elongation at break and toughness up to three-fold under photolysis at elevated temperature of 70°C. The resultant adhesive attaches low-surface energy silicon rubber substrates onto tissue, supporting up to 1 kg loads. The hybrid modes of activation (light/temperature) could improve control over crosslinking kinetics and material properties using other types of polymers such as polyacrylates and polyolefins. |
| first_indexed | 2024-10-01T03:30:34Z |
| format | Conference Paper |
| id | ntu-10356/174202 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:30:34Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1742022024-05-31T15:51:25Z Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive Ang, Elwin Wei Jian Steele, Terry W. J. School of Materials Science and Engineering Interdisciplinary Graduate School (IGS) 12th World Biomaterials Congress (WBC 2024) Nanyang Environment and Water Research Institute Engineering Dual stimuli Bioadhesive Carbene Carbene based bioadhesives are developmental tissue adhesive, where photolysis creates carbenes that indiscriminately insert into amino acids. However, the nitrogen side product generates internal pores, creating a relatively weak cohesive matrix. To further improve cohesive toughness, photo-curing at elevated temperatures hypothesizes higher nitrogen solubility and lower apparent viscosity in order to generate higher crosslinking density. Real-time crosslinking kinetics of storage (G’) and loss (G”) moduli and adhesive properties post-activation (viscosity, yield stress and modulus of toughness) are characterised through a custom photorheometer setup with a high thermal-conductivity, temperature-controlled diamond plate. Dual activation improved elongation at break and toughness up to three-fold under photolysis at elevated temperature of 70°C. The resultant adhesive attaches low-surface energy silicon rubber substrates onto tissue, supporting up to 1 kg loads. The hybrid modes of activation (light/temperature) could improve control over crosslinking kinetics and material properties using other types of polymers such as polyacrylates and polyolefins. Ministry of Education (MOE) 2024-05-31T07:45:10Z 2024-05-31T07:45:10Z 2024 Conference Paper Ang, E. W. J. & Steele, T. W. J. (2024). Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive. 12th World Biomaterials Congress (WBC 2024). https://hdl.handle.net/10356/174202 https://wbc2024.com/ en © 2024 WBC. All rights reserved. application/pdf |
| spellingShingle | Engineering Dual stimuli Bioadhesive Carbene Ang, Elwin Wei Jian Steele, Terry W. J. Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive |
| title | Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive |
| title_full | Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive |
| title_fullStr | Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive |
| title_full_unstemmed | Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive |
| title_short | Dual stimuli activation for tougher diazirine-grafted polycaprolactone bioadhesive |
| title_sort | dual stimuli activation for tougher diazirine grafted polycaprolactone bioadhesive |
| topic | Engineering Dual stimuli Bioadhesive Carbene |
| url | https://hdl.handle.net/10356/174202 https://wbc2024.com/ |
| work_keys_str_mv | AT angelwinweijian dualstimuliactivationfortougherdiazirinegraftedpolycaprolactonebioadhesive AT steeleterrywj dualstimuliactivationfortougherdiazirinegraftedpolycaprolactonebioadhesive |