Tougher bioadhesives through dual stimulation strategies
Carbene based bioadhesives have favourable attributes for tissue adhesion, including non-specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene-precursor (diazirine) also creates inert side products that are absent u...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/174221 |
| _version_ | 1811686507787845632 |
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| author | Ang, Elwin Wei Jian Djordjevic, Ivan Solic, Ivan Goh, Chen Yee Steele, Terry W. J. |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Ang, Elwin Wei Jian Djordjevic, Ivan Solic, Ivan Goh, Chen Yee Steele, Terry W. J. |
| author_sort | Ang, Elwin Wei Jian |
| collection | NTU |
| description | Carbene based bioadhesives have favourable attributes for tissue adhesion, including non-specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene-precursor (diazirine) also creates inert side products that are absent under thermal activation. Herein, a dual activation method combines light irradiation at elevated temperatures for the evaluation of diazirine depletion and effects on cohesive properties. A customized photo/thermal-rheometer evaluates viscoelastic properties, correlated to the kinetics of carbene:diazoalkane ratios via 19F NMR. The latter exploits the sensitive -CF3 functional group to determine joule-based light/temperature kinetics on trifluoroaryl diazirine consumption. The combination of heat and photoactivation produced bioadhesives that are 3x tougher compared to control. Dual thermal/light irradiation may be a strategy to improve viscoelastic dissipation and toughness of photo-activated adhesive resins. |
| first_indexed | 2024-10-01T05:01:31Z |
| format | Journal Article |
| id | ntu-10356/174221 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:01:31Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1742212024-03-22T15:46:16Z Tougher bioadhesives through dual stimulation strategies Ang, Elwin Wei Jian Djordjevic, Ivan Solic, Ivan Goh, Chen Yee Steele, Terry W. J. School of Materials Science and Engineering Interdisciplinary Graduate School (IGS) Nanyang Environment and Water Research Institute Engineering Other Polycaprolactone Diazirine Carbene Bioadhesive Dual-activation Rheology Nuclear magnetic resonance spectroscopy Carbene based bioadhesives have favourable attributes for tissue adhesion, including non-specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene-precursor (diazirine) also creates inert side products that are absent under thermal activation. Herein, a dual activation method combines light irradiation at elevated temperatures for the evaluation of diazirine depletion and effects on cohesive properties. A customized photo/thermal-rheometer evaluates viscoelastic properties, correlated to the kinetics of carbene:diazoalkane ratios via 19F NMR. The latter exploits the sensitive -CF3 functional group to determine joule-based light/temperature kinetics on trifluoroaryl diazirine consumption. The combination of heat and photoactivation produced bioadhesives that are 3x tougher compared to control. Dual thermal/light irradiation may be a strategy to improve viscoelastic dissipation and toughness of photo-activated adhesive resins. National Research Foundation (NRF) Public Utilities Board (PUB) Submitted/Accepted version The project was supported by Ministry of Education Grants (MOE2018-T2-2-114) CaproGlu, Double sided wet-tissue adhesives; MOE-T2EP10222-0005, Nontoxic carbene photoinitiators for sustainable biomaterials; RG47/21, Electrocuring Resins for Advanced Manufacturing; RT07/20 Fiber-optic orthopaedic implants for bone-implant adhesion. This research is supported by the National Research Foundation, Singapore, and PUB, Singapore's National Water Agency under its RIE2025 Urban Solutions and Sustainability (USS) (Water) Centre of Excellence (CoE) Programme, awarded to Nanyang Environment & Water Research Institute (NEWRI), Nanyang Technological University, Singapore (NTU). 2024-03-21T07:51:59Z 2024-03-21T07:51:59Z 2024 Journal Article Ang, E. W. J., Djordjevic, I., Solic, I., Goh, C. Y. & Steele, T. W. J. (2024). Tougher bioadhesives through dual stimulation strategies. Advanced Healthcare Materials. https://dx.doi.org/10.1002/adhm.202303666 2192-2640 https://hdl.handle.net/10356/174221 10.1002/adhm.202303666 en MOE2018-T2-2-114 MOE-T2EP10222-0005 RT07/20 RIE2025 Advanced Healthcare Materials © 2024 Wiley-VCH GmbH. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1002/adhm.202303666. application/pdf application/pdf |
| spellingShingle | Engineering Other Polycaprolactone Diazirine Carbene Bioadhesive Dual-activation Rheology Nuclear magnetic resonance spectroscopy Ang, Elwin Wei Jian Djordjevic, Ivan Solic, Ivan Goh, Chen Yee Steele, Terry W. J. Tougher bioadhesives through dual stimulation strategies |
| title | Tougher bioadhesives through dual stimulation strategies |
| title_full | Tougher bioadhesives through dual stimulation strategies |
| title_fullStr | Tougher bioadhesives through dual stimulation strategies |
| title_full_unstemmed | Tougher bioadhesives through dual stimulation strategies |
| title_short | Tougher bioadhesives through dual stimulation strategies |
| title_sort | tougher bioadhesives through dual stimulation strategies |
| topic | Engineering Other Polycaprolactone Diazirine Carbene Bioadhesive Dual-activation Rheology Nuclear magnetic resonance spectroscopy |
| url | https://hdl.handle.net/10356/174221 |
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