Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice
Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific manner. Estrogen increases the attachment and colonization of C. m...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/174259 |
| _version_ | 1824456372263059456 |
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| author | Li, Qing Chan, Hung Liu, Wei-Xin Liu, Chang-An Zhou, Yunfei Huang, Dan Wang, Xueliang Li, Xiaoxing Xie, Chuan Liu, Wing Ying-Zhi Wang, Xian-Song Ng, Siu Kin Gou, Hongyan Zhao, Liu-Yang Fong, Winnie Jiang, Lanping Lin, Yufeng Zhao, Guijun Bai, Feihu Liu, Xiaodong Chen, Huarong Zhang, Lin Wong, Sunny Hei Chan, Matthew Tak Vai Wu, William Ka Kei Yu, Jun |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Li, Qing Chan, Hung Liu, Wei-Xin Liu, Chang-An Zhou, Yunfei Huang, Dan Wang, Xueliang Li, Xiaoxing Xie, Chuan Liu, Wing Ying-Zhi Wang, Xian-Song Ng, Siu Kin Gou, Hongyan Zhao, Liu-Yang Fong, Winnie Jiang, Lanping Lin, Yufeng Zhao, Guijun Bai, Feihu Liu, Xiaodong Chen, Huarong Zhang, Lin Wong, Sunny Hei Chan, Matthew Tak Vai Wu, William Ka Kei Yu, Jun |
| author_sort | Li, Qing |
| collection | NTU |
| description | Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific manner. Estrogen increases the attachment and colonization of C. maltaromaticum via increasing the colonic expression of SLC3A2 that binds to DD-CPase of this bacterium. Metabolomic and transcriptomic profiling unveils the increased gut abundance of vitamin D-related metabolites and the mucosal activation of vitamin D receptor (VDR) signaling in C. maltaromaticum-gavaged mice in a gut microbiome- and VDR-dependent manner. In vitro fermentation system confirms the metabolic cross-feeding of C. maltaromaticum with Faecalibacterium prausnitzii to convert C. maltaromaticum-produced 7-dehydrocholesterol into vitamin D for activating the host VDR signaling. Overall, C. maltaromaticum colonizes the gut in an estrogen-dependent manner and acts along with other microbes to augment the intestinal vitamin D production to activate the host VDR for suppressing CRC. |
| first_indexed | 2025-02-19T03:53:03Z |
| format | Journal Article |
| id | ntu-10356/174259 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:53:03Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1742592024-03-31T15:40:33Z Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice Li, Qing Chan, Hung Liu, Wei-Xin Liu, Chang-An Zhou, Yunfei Huang, Dan Wang, Xueliang Li, Xiaoxing Xie, Chuan Liu, Wing Ying-Zhi Wang, Xian-Song Ng, Siu Kin Gou, Hongyan Zhao, Liu-Yang Fong, Winnie Jiang, Lanping Lin, Yufeng Zhao, Guijun Bai, Feihu Liu, Xiaodong Chen, Huarong Zhang, Lin Wong, Sunny Hei Chan, Matthew Tak Vai Wu, William Ka Kei Yu, Jun Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Colon cancer Estrogen Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific manner. Estrogen increases the attachment and colonization of C. maltaromaticum via increasing the colonic expression of SLC3A2 that binds to DD-CPase of this bacterium. Metabolomic and transcriptomic profiling unveils the increased gut abundance of vitamin D-related metabolites and the mucosal activation of vitamin D receptor (VDR) signaling in C. maltaromaticum-gavaged mice in a gut microbiome- and VDR-dependent manner. In vitro fermentation system confirms the metabolic cross-feeding of C. maltaromaticum with Faecalibacterium prausnitzii to convert C. maltaromaticum-produced 7-dehydrocholesterol into vitamin D for activating the host VDR signaling. Overall, C. maltaromaticum colonizes the gut in an estrogen-dependent manner and acts along with other microbes to augment the intestinal vitamin D production to activate the host VDR for suppressing CRC. Published version This project was supported by National Key R&D Program of China (No. 2020YFA0509200/2020YFA0509203), Research Talent Hub (RTH)-ITF scheme Hong Kong (ITS/177/21FP), RGC Research Impact Fund Hong Kong (R4632-21F), RGC Theme-based Research Scheme Hong Kong (T21-705/20-N), RGC-CRF Hong Kong (C4039-19GF, C7065-18GF), RGC-GRF Hong Kong (14110819, 14111621, 14116722), Vice-Chancellor’s Discretionary Fund of CUHK, and Research Grants Council of the Hong Kong Special Administrative Region, China (CUHK PDFS2122-4S03). 2024-03-25T01:03:38Z 2024-03-25T01:03:38Z 2023 Journal Article Li, Q., Chan, H., Liu, W., Liu, C., Zhou, Y., Huang, D., Wang, X., Li, X., Xie, C., Liu, W. Y., Wang, X., Ng, S. K., Gou, H., Zhao, L., Fong, W., Jiang, L., Lin, Y., Zhao, G., Bai, F., ...Yu, J. (2023). Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice. Cancer Cell, 41(8), 1450-1465.e8. https://dx.doi.org/10.1016/j.ccell.2023.06.011 1535-6108 https://hdl.handle.net/10356/174259 10.1016/j.ccell.2023.06.011 37478851 2-s2.0-85166913553 8 41 1450 1465.e8 en Cancer cell © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Colon cancer Estrogen Li, Qing Chan, Hung Liu, Wei-Xin Liu, Chang-An Zhou, Yunfei Huang, Dan Wang, Xueliang Li, Xiaoxing Xie, Chuan Liu, Wing Ying-Zhi Wang, Xian-Song Ng, Siu Kin Gou, Hongyan Zhao, Liu-Yang Fong, Winnie Jiang, Lanping Lin, Yufeng Zhao, Guijun Bai, Feihu Liu, Xiaodong Chen, Huarong Zhang, Lin Wong, Sunny Hei Chan, Matthew Tak Vai Wu, William Ka Kei Yu, Jun Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice |
| title | Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice |
| title_full | Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice |
| title_fullStr | Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice |
| title_full_unstemmed | Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice |
| title_short | Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice |
| title_sort | carnobacterium maltaromaticum boosts intestinal vitamin d production to suppress colorectal cancer in female mice |
| topic | Medicine, Health and Life Sciences Colon cancer Estrogen |
| url | https://hdl.handle.net/10356/174259 |
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