Electron tunneling in ferritin and associated biosystems
Ferritin is a 12 nanometer (nm) diameter iron storage protein complex that is found in most plants and animals. A substantial body of evidence has established that electrons can tunnel through and between ferritin protein nanoparticles and that it exhibits Coulomb blockade behavior, which is also se...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/174271 |
| _version_ | 1811679263309430784 |
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| author | Perez, Ismael Diez Lim, Sierin Nijhuis, Christian A. Pluchery, Olivier Rourk, Christopher J. |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Perez, Ismael Diez Lim, Sierin Nijhuis, Christian A. Pluchery, Olivier Rourk, Christopher J. |
| author_sort | Perez, Ismael Diez |
| collection | NTU |
| description | Ferritin is a 12 nanometer (nm) diameter iron storage protein complex that is found in most plants and animals. A substantial body of evidence has established that electrons can tunnel through and between ferritin protein nanoparticles and that it exhibits Coulomb blockade behavior, which is also seen in quantum dots and nanoparticles. This evidence can be used to understand the behavior of these particles for use in nanoelectronic devices, for biomedical applications and for investigation of quantum biological phenomena. Ferritin also has magnetic properties that make it useful for applications such as memristors and as a contrast agent for magnetic resonance imaging. This article provides a short overview of this evidence, as well as evidence of ferritin structures in vivo and of tunneling in those structures, with an emphasis on ferritin structures in substantia nigra pars compacta (SNc) neurons. Potential biomedical applications that could utilize these ferritin protein nanoparticles are also discussed. |
| first_indexed | 2024-10-01T03:06:22Z |
| format | Journal Article |
| id | ntu-10356/174271 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:06:22Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1742712024-03-29T15:31:43Z Electron tunneling in ferritin and associated biosystems Perez, Ismael Diez Lim, Sierin Nijhuis, Christian A. Pluchery, Olivier Rourk, Christopher J. School of Chemistry, Chemical Engineering and Biotechnology Engineering Ferritin Electron tunneling Ferritin is a 12 nanometer (nm) diameter iron storage protein complex that is found in most plants and animals. A substantial body of evidence has established that electrons can tunnel through and between ferritin protein nanoparticles and that it exhibits Coulomb blockade behavior, which is also seen in quantum dots and nanoparticles. This evidence can be used to understand the behavior of these particles for use in nanoelectronic devices, for biomedical applications and for investigation of quantum biological phenomena. Ferritin also has magnetic properties that make it useful for applications such as memristors and as a contrast agent for magnetic resonance imaging. This article provides a short overview of this evidence, as well as evidence of ferritin structures in vivo and of tunneling in those structures, with an emphasis on ferritin structures in substantia nigra pars compacta (SNc) neurons. Potential biomedical applications that could utilize these ferritin protein nanoparticles are also discussed. Published version 2024-03-25T04:31:28Z 2024-03-25T04:31:28Z 2023 Journal Article Perez, I. D., Lim, S., Nijhuis, C. A., Pluchery, O. & Rourk, C. J. (2023). Electron tunneling in ferritin and associated biosystems. IEEE Transactions On Molecular, Biological, and Multi-Scale Communications, 9(2), 263-272. https://dx.doi.org/10.1109/TMBMC.2023.3275793 2332-7804 https://hdl.handle.net/10356/174271 10.1109/TMBMC.2023.3275793 2-s2.0-85162869327 2 9 263 272 en IEEE Transactions on Molecular, Biological, and Multi-Scale Communications © The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. For more information, see https://creativecommons.org/licenses/by-nc-nd/4.0/. application/pdf |
| spellingShingle | Engineering Ferritin Electron tunneling Perez, Ismael Diez Lim, Sierin Nijhuis, Christian A. Pluchery, Olivier Rourk, Christopher J. Electron tunneling in ferritin and associated biosystems |
| title | Electron tunneling in ferritin and associated biosystems |
| title_full | Electron tunneling in ferritin and associated biosystems |
| title_fullStr | Electron tunneling in ferritin and associated biosystems |
| title_full_unstemmed | Electron tunneling in ferritin and associated biosystems |
| title_short | Electron tunneling in ferritin and associated biosystems |
| title_sort | electron tunneling in ferritin and associated biosystems |
| topic | Engineering Ferritin Electron tunneling |
| url | https://hdl.handle.net/10356/174271 |
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