Unveiling the influence of tumor microenvironment and spatial heterogeneity on temozolomide resistance in glioblastoma using an advanced human in vitro model of the blood-brain barrier and glioblastoma

Unveiling the influence of tumor microenvironment and spatial heterogeneity on temozolomide resistance in glioblastoma using an advanced human in vitro model of the blood-brain barrier and glioblastoma

Glioblastoma (GBM) is the most common primary malignant brain cancer in adults with a dismal prognosis. Temozolomide (TMZ) is the first-in-line chemotherapeutic; however, resistance is frequent and multifactorial. While many molecular and genetic factors have been linked to TMZ resistance, the role...

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Bibliographic Details
Main Authors: Lam, Maxine S. Y., Aw, Joey J. Y., Tan, Damien, Vijayakumar, Ragavi, Lim, Grace Hui Yi, Yada, Swathi, Pang, Qing You, Barker, Nick, Tang, Carol, Ang, Beng Ti, Sobota, Radoslaw M., Pavesi, Andrea
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Blood-brain barrier
Chemoresistance
Online Access:https://hdl.handle.net/10356/174305

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