Unravelling mitochondrial impairment in spinocerebellar ataxia 3: insights from neuroblastoma cells and human induced pluripotent stem cells
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by the abnormal CAG repeat expansion in the ATXN3 gene, resulting in an expanded polyglutamine tract within the ataxin-3 protein. Despite significant progress in comprehending SCA3 etiology, the underlying disease mechanisms...
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| Format: | Thesis-Master by Research |
| Language: | English |
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Nanyang Technological University
2024
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| Online Access: | https://hdl.handle.net/10356/174347 |