Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its epigenomic aberrations are not fully elucidated apart from DNA hypermet...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/174488 |
| _version_ | 1824453260592807936 |
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| author | Mizokami, Harue Okabe, Atsushi Choudhary, Ruchi Mima, Masato Saeda, Kenta Fukuyo, Masaki Rahmutulla, Bahityar Seki, Motoaki Goh, Boon-Cher Kondo, Satoru Dochi, Hirotomo Moriyama-Kita, Makiko Misawa, Kiyoshi Hanazawa, Toyoyuki Tan, Patrick Yoshizaki, Tomokazu Fullwood, Melissa Jane Kaneda, Atsushi |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Mizokami, Harue Okabe, Atsushi Choudhary, Ruchi Mima, Masato Saeda, Kenta Fukuyo, Masaki Rahmutulla, Bahityar Seki, Motoaki Goh, Boon-Cher Kondo, Satoru Dochi, Hirotomo Moriyama-Kita, Makiko Misawa, Kiyoshi Hanazawa, Toyoyuki Tan, Patrick Yoshizaki, Tomokazu Fullwood, Melissa Jane Kaneda, Atsushi |
| author_sort | Mizokami, Harue |
| collection | NTU |
| description | Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its epigenomic aberrations are not fully elucidated apart from DNA hypermethylation. Epigenomic rewiring and enhancer dysregulation, such as enhancer hijacking due to genomic structural changes or extrachromosomal DNA, drive cancer progression. |
| first_indexed | 2024-10-01T07:57:33Z |
| format | Journal Article |
| id | ntu-10356/174488 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:57:33Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1744882024-04-01T15:32:27Z Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma Mizokami, Harue Okabe, Atsushi Choudhary, Ruchi Mima, Masato Saeda, Kenta Fukuyo, Masaki Rahmutulla, Bahityar Seki, Motoaki Goh, Boon-Cher Kondo, Satoru Dochi, Hirotomo Moriyama-Kita, Makiko Misawa, Kiyoshi Hanazawa, Toyoyuki Tan, Patrick Yoshizaki, Tomokazu Fullwood, Melissa Jane Kaneda, Atsushi School of Biological Sciences Institute of Molecular and Cell Biology, A*STAR National University of Singapore Medicine, Health and Life Sciences Epstein-Barr virus Nasopharyngeal carcinoma Enhancer infestation Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its epigenomic aberrations are not fully elucidated apart from DNA hypermethylation. Epigenomic rewiring and enhancer dysregulation, such as enhancer hijacking due to genomic structural changes or extrachromosomal DNA, drive cancer progression. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This study was supported by the grants from the Japan Agency for Medical Research and Development (19ck0106263h0003 and 22zf0127008s0301 to AK) (data collection and analysis), Japan Society for the Promotion of Science (20K18271, 22K19553, and JPJSCCA20200006 to AK) (data collection and analysis), the Singapore Ministry of Health’s National Medical Research Council under its Singapore Translational Research Investigator Award STaR (MOH000709 to BCG (PI) and MJF(Co-I)) (data collection and analysis), the Ministry of Education, Singapore, under its Academic Research Fund Tier 1 (RG86/21 to MJF (PI)) (data collection and analysis), Global and Prominent Research 2018-Y9 and IAAR Research Support Program from Chiba University (to AK) (data collection and analysis). 2024-04-01T05:08:19Z 2024-04-01T05:08:19Z 2024 Journal Article Mizokami, H., Okabe, A., Choudhary, R., Mima, M., Saeda, K., Fukuyo, M., Rahmutulla, B., Seki, M., Goh, B., Kondo, S., Dochi, H., Moriyama-Kita, M., Misawa, K., Hanazawa, T., Tan, P., Yoshizaki, T., Fullwood, M. J. & Kaneda, A. (2024). Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma. EBioMedicine, 102, 105057-. https://dx.doi.org/10.1016/j.ebiom.2024.105057 2352-3964 https://hdl.handle.net/10356/174488 10.1016/j.ebiom.2024.105057 38490101 2-s2.0-85188106067 102 105057 en MOH000709 RG86/21 eBioMedicine © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Epstein-Barr virus Nasopharyngeal carcinoma Enhancer infestation Mizokami, Harue Okabe, Atsushi Choudhary, Ruchi Mima, Masato Saeda, Kenta Fukuyo, Masaki Rahmutulla, Bahityar Seki, Motoaki Goh, Boon-Cher Kondo, Satoru Dochi, Hirotomo Moriyama-Kita, Makiko Misawa, Kiyoshi Hanazawa, Toyoyuki Tan, Patrick Yoshizaki, Tomokazu Fullwood, Melissa Jane Kaneda, Atsushi Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma |
| title | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma |
| title_full | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma |
| title_fullStr | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma |
| title_full_unstemmed | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma |
| title_short | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma |
| title_sort | enhancer infestation drives tumorigenic activation of inactive b compartment in epstein barr virus positive nasopharyngeal carcinoma |
| topic | Medicine, Health and Life Sciences Epstein-Barr virus Nasopharyngeal carcinoma Enhancer infestation |
| url | https://hdl.handle.net/10356/174488 |
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