Adaptive adhesions of barnacle-inspired adhesive peptides
The strategy of robust adhesion employed by barnacles renders them a fascinating biomimetic candidate for developing novel wet adhesives. Particularly, barnacle cement protein 19k (cp19k) has been speculated to be the key adhesive protein establishing the priming layer in the initial barnacle cement...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/174546 |
| _version_ | 1811694107550023680 |
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| author | Mondarte, Evan Angelo Quimada Wang, Jining Yu, Jing |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Mondarte, Evan Angelo Quimada Wang, Jining Yu, Jing |
| author_sort | Mondarte, Evan Angelo Quimada |
| collection | NTU |
| description | The strategy of robust adhesion employed by barnacles renders them a fascinating biomimetic candidate for developing novel wet adhesives. Particularly, barnacle cement protein 19k (cp19k) has been speculated to be the key adhesive protein establishing the priming layer in the initial barnacle cement construction. In this work, we systematically studied the sequence design rationale of cp19k by designing adhesive peptides inspired from the low complexity STGA-rich and the charged segments of cp19k. Combining structure analysis and adhesion performance test, we found that cp19k-inspired adhesive peptides possess excellent disparate adhesion strategies for both hydrophilic mica and hydrophobic self-assembled monolayer surfaces. Specifically, low complexity STGA-rich segment offers great structure flexibility for surface adhesion while the hydrophobic and charged residues can contribute to the adhesion of the peptides on hydrophobic and charged surfaces. The adhesion strategy identified in this work broadens our comprehension of barnacle adhesion mechanisms and offers valuable insights for designing advanced wet adhesives with exceptional performance. |
| first_indexed | 2024-10-01T07:02:19Z |
| format | Journal Article |
| id | ntu-10356/174546 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:02:19Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1745462024-04-05T15:47:36Z Adaptive adhesions of barnacle-inspired adhesive peptides Mondarte, Evan Angelo Quimada Wang, Jining Yu, Jing School of Materials Science and Engineering Singapore Membrane Technology Centre Nanyang Environment and Water Research Institute Institute for Digital Molecular Analytics and Science Chemistry Wet adhesion Hydrogen bonds The strategy of robust adhesion employed by barnacles renders them a fascinating biomimetic candidate for developing novel wet adhesives. Particularly, barnacle cement protein 19k (cp19k) has been speculated to be the key adhesive protein establishing the priming layer in the initial barnacle cement construction. In this work, we systematically studied the sequence design rationale of cp19k by designing adhesive peptides inspired from the low complexity STGA-rich and the charged segments of cp19k. Combining structure analysis and adhesion performance test, we found that cp19k-inspired adhesive peptides possess excellent disparate adhesion strategies for both hydrophilic mica and hydrophobic self-assembled monolayer surfaces. Specifically, low complexity STGA-rich segment offers great structure flexibility for surface adhesion while the hydrophobic and charged residues can contribute to the adhesion of the peptides on hydrophobic and charged surfaces. The adhesion strategy identified in this work broadens our comprehension of barnacle adhesion mechanisms and offers valuable insights for designing advanced wet adhesives with exceptional performance. Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version This work is supported by the Singapore National Research Fellowship (NRF-NRFF11-2019-0004) and the Singapore Ministry of Education (MOE) Tier 2 Grant (MOE-T2EP30220-0006). 2024-04-03T04:39:46Z 2024-04-03T04:39:46Z 2023 Journal Article Mondarte, E. A. Q., Wang, J. & Yu, J. (2023). Adaptive adhesions of barnacle-inspired adhesive peptides. ACS Biomaterials Science & Engineering, 9(10), 5679-5686. https://dx.doi.org/10.1021/acsbiomaterials.3c01047 2373-9878 https://hdl.handle.net/10356/174546 10.1021/acsbiomaterials.3c01047 37722068 2-s2.0-85173577721 10 9 5679 5686 en NRF-NRFF11-2019-0004 MOE-T2EP30220-0006 ACS Biomaterials Science & Engineering © 2023 American Chemical Society. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1021/acsbiomaterials.3c01047. application/pdf |
| spellingShingle | Chemistry Wet adhesion Hydrogen bonds Mondarte, Evan Angelo Quimada Wang, Jining Yu, Jing Adaptive adhesions of barnacle-inspired adhesive peptides |
| title | Adaptive adhesions of barnacle-inspired adhesive peptides |
| title_full | Adaptive adhesions of barnacle-inspired adhesive peptides |
| title_fullStr | Adaptive adhesions of barnacle-inspired adhesive peptides |
| title_full_unstemmed | Adaptive adhesions of barnacle-inspired adhesive peptides |
| title_short | Adaptive adhesions of barnacle-inspired adhesive peptides |
| title_sort | adaptive adhesions of barnacle inspired adhesive peptides |
| topic | Chemistry Wet adhesion Hydrogen bonds |
| url | https://hdl.handle.net/10356/174546 |
| work_keys_str_mv | AT mondarteevanangeloquimada adaptiveadhesionsofbarnacleinspiredadhesivepeptides AT wangjining adaptiveadhesionsofbarnacleinspiredadhesivepeptides AT yujing adaptiveadhesionsofbarnacleinspiredadhesivepeptides |