Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications
Mid-infrared absorption spectroscopy is a powerful tool to measure and analyze composition, concentration and structure of substance molecules. Due to the advantages of noninvasive, label-free and real time, it is widely used to assist analysis and diagnosis in the biomedical field. In order to meet...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/174554 |
| _version_ | 1811678484848705536 |
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| author | An, Donglai Sun, Fangyuan Bian, Yupei Ni, Jing Wang, Qi Jie Yu, Xia |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering An, Donglai Sun, Fangyuan Bian, Yupei Ni, Jing Wang, Qi Jie Yu, Xia |
| author_sort | An, Donglai |
| collection | NTU |
| description | Mid-infrared absorption spectroscopy is a powerful tool to measure and analyze composition, concentration and structure of substance molecules. Due to the advantages of noninvasive, label-free and real time, it is widely used to assist analysis and diagnosis in the biomedical field. In order to meet the analysis demand of low concentration clinical samples, the limit of detection (LOD) needs to be continuously enhanced. In this study, typical enhancement technologies for mid-infrared absorption spectroscopy are reviewed, including tunable diode Laser absorption spectroscopy (TDLAS), dual-comb absorption spectroscopy (DAS), cavity enhanced spectroscopy, hollow waveguide absorption spectroscopy (HWGAS), surface enhancement infrared absorption (SEIRA), and photoacoustic spectroscopy (PAS). Particular attention is paid to the application of these enhancement technologies in the biomedical field of breath analysis, body fluid detection, structure and conformational transition of proteins, food and drug quality monitoring. This review provides a comprehensive technology reference of mid-infrared absorption spectroscopy, as well as discussions on its application aspects in biomedical field. |
| first_indexed | 2024-10-01T02:54:00Z |
| format | Journal Article |
| id | ntu-10356/174554 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:54:00Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1745542024-04-05T15:41:02Z Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications An, Donglai Sun, Fangyuan Bian, Yupei Ni, Jing Wang, Qi Jie Yu, Xia School of Electrical and Electronic Engineering School of Physical and Mathematical Sciences Centre for Disruptive Photonic Technologies (CDPT) Medicine, Health and Life Sciences Mid infrared absorption Laser absorption spectroscopy Cavity enhanced spectroscopy Surface enhanced infrared absorption Photoacoustic spectroscopy Biomedical diagnosis Mid-infrared absorption spectroscopy is a powerful tool to measure and analyze composition, concentration and structure of substance molecules. Due to the advantages of noninvasive, label-free and real time, it is widely used to assist analysis and diagnosis in the biomedical field. In order to meet the analysis demand of low concentration clinical samples, the limit of detection (LOD) needs to be continuously enhanced. In this study, typical enhancement technologies for mid-infrared absorption spectroscopy are reviewed, including tunable diode Laser absorption spectroscopy (TDLAS), dual-comb absorption spectroscopy (DAS), cavity enhanced spectroscopy, hollow waveguide absorption spectroscopy (HWGAS), surface enhancement infrared absorption (SEIRA), and photoacoustic spectroscopy (PAS). Particular attention is paid to the application of these enhancement technologies in the biomedical field of breath analysis, body fluid detection, structure and conformational transition of proteins, food and drug quality monitoring. This review provides a comprehensive technology reference of mid-infrared absorption spectroscopy, as well as discussions on its application aspects in biomedical field. National Medical Research Council (NMRC) Submitted/Accepted version This work was supported by the National Key R&D Program of China 2022YFE0102300 and National Medical Research Council (NMRC) under the Singapore China joint grant on infectious diseases (MOH 000927). 2024-04-03T04:58:58Z 2024-04-03T04:58:58Z 2023 Journal Article An, D., Sun, F., Bian, Y., Ni, J., Wang, Q. J. & Yu, X. (2023). Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications. Applied Spectroscopy Reviews, 58(10), 834-868. https://dx.doi.org/10.1080/05704928.2022.2156527 0570-4928 https://hdl.handle.net/10356/174554 10.1080/05704928.2022.2156527 2-s2.0-85144100809 10 58 834 868 en MOH 000927 Applied Spectroscopy Reviews © 2022 Taylor & Francis Group, LLC. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1080/05704928.2022.2156527. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Mid infrared absorption Laser absorption spectroscopy Cavity enhanced spectroscopy Surface enhanced infrared absorption Photoacoustic spectroscopy Biomedical diagnosis An, Donglai Sun, Fangyuan Bian, Yupei Ni, Jing Wang, Qi Jie Yu, Xia Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| title | Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| title_full | Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| title_fullStr | Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| title_full_unstemmed | Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| title_short | Mid-infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| title_sort | mid infrared absorption spectroscopy with enhanced detection performance for biomedical applications |
| topic | Medicine, Health and Life Sciences Mid infrared absorption Laser absorption spectroscopy Cavity enhanced spectroscopy Surface enhanced infrared absorption Photoacoustic spectroscopy Biomedical diagnosis |
| url | https://hdl.handle.net/10356/174554 |
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