Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO)
Background: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/174723 |
| _version_ | 1811692110261256192 |
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| author | Ng, Dorothy Hui Lin Chia, Travis Ren Teen Young, Barnaby Edward Sadarangani, Sapna Puah, Ser Hon Low, Jenny Guek Hong Yan, Gabriel Zherong Mo, Yin Ngiam, Nicholas Jinghao Wang, Samuel Sherng Young Loo, Yan Tong Ong, Faith Evangeline Jie Qi Li, Andrew Yunkai Ho, Sharlene Ng, Lisa Tambyah, Paul Anantharajah Yeo, Tsin Wen |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ng, Dorothy Hui Lin Chia, Travis Ren Teen Young, Barnaby Edward Sadarangani, Sapna Puah, Ser Hon Low, Jenny Guek Hong Yan, Gabriel Zherong Mo, Yin Ngiam, Nicholas Jinghao Wang, Samuel Sherng Young Loo, Yan Tong Ong, Faith Evangeline Jie Qi Li, Andrew Yunkai Ho, Sharlene Ng, Lisa Tambyah, Paul Anantharajah Yeo, Tsin Wen |
| author_sort | Ng, Dorothy Hui Lin |
| collection | NTU |
| description | Background: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region. Methods: RESPIRO is being conducted at three major tertiary hospitals in Singapore. Adults hospitalised with acute community-acquired pneumonia or lower respiratory tract infections, based on established clinical, laboratory and radiological criteria, will be recruited. Over the course of the illness, clinical data and biological samples will be collected longitudinally and stored in a biorepository for future analysis. Discussion: The RESPIRO study is designed to be hypothesis generating, complementary to and easily integrated with other research projects and clinical trials. The detailed clinical database and biorepository will yield insights into the epidemiology and outcomes of community-acquired lower respiratory tract infections in Singapore and the surrounding region and offers the opportunity to deeply characterise the microbiology and immunopathology of community-acquired pneumonia. |
| first_indexed | 2024-10-01T06:30:34Z |
| format | Journal Article |
| id | ntu-10356/174723 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:30:34Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1747232024-04-14T15:40:45Z Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) Ng, Dorothy Hui Lin Chia, Travis Ren Teen Young, Barnaby Edward Sadarangani, Sapna Puah, Ser Hon Low, Jenny Guek Hong Yan, Gabriel Zherong Mo, Yin Ngiam, Nicholas Jinghao Wang, Samuel Sherng Young Loo, Yan Tong Ong, Faith Evangeline Jie Qi Li, Andrew Yunkai Ho, Sharlene Ng, Lisa Tambyah, Paul Anantharajah Yeo, Tsin Wen Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Medicine, Health and Life Sciences Community-acquired pneumonia Pathogenesis Background: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region. Methods: RESPIRO is being conducted at three major tertiary hospitals in Singapore. Adults hospitalised with acute community-acquired pneumonia or lower respiratory tract infections, based on established clinical, laboratory and radiological criteria, will be recruited. Over the course of the illness, clinical data and biological samples will be collected longitudinally and stored in a biorepository for future analysis. Discussion: The RESPIRO study is designed to be hypothesis generating, complementary to and easily integrated with other research projects and clinical trials. The detailed clinical database and biorepository will yield insights into the epidemiology and outcomes of community-acquired lower respiratory tract infections in Singapore and the surrounding region and offers the opportunity to deeply characterise the microbiology and immunopathology of community-acquired pneumonia. National Medical Research Council (NMRC) Published version This study is funded by the National Medical Research Council (NMRC) Open Fund Large Collaborative Grant (Award ID: OFLCG19May-0034). It has no role in the conceptualization, design, data collection, analysis, or decision to publish and in preparation of the manuscript. 2024-04-08T06:26:36Z 2024-04-08T06:26:36Z 2024 Journal Article Ng, D. H. L., Chia, T. R. T., Young, B. E., Sadarangani, S., Puah, S. H., Low, J. G. H., Yan, G. Z., Mo, Y., Ngiam, N. J., Wang, S. S. Y., Loo, Y. T., Ong, F. E. J. Q., Li, A. Y., Ho, S., Ng, L., Tambyah, P. A. & Yeo, T. W. (2024). Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO). BMC Infectious Diseases, 24(1), 123-. https://dx.doi.org/10.1186/s12879-023-08795-8 1471-2334 https://hdl.handle.net/10356/174723 10.1186/s12879-023-08795-8 38262970 2-s2.0-85183356192 1 24 123 en OFLCG19May‐0034 BMC Infectious Diseases © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Community-acquired pneumonia Pathogenesis Ng, Dorothy Hui Lin Chia, Travis Ren Teen Young, Barnaby Edward Sadarangani, Sapna Puah, Ser Hon Low, Jenny Guek Hong Yan, Gabriel Zherong Mo, Yin Ngiam, Nicholas Jinghao Wang, Samuel Sherng Young Loo, Yan Tong Ong, Faith Evangeline Jie Qi Li, Andrew Yunkai Ho, Sharlene Ng, Lisa Tambyah, Paul Anantharajah Yeo, Tsin Wen Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) |
| title | Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) |
| title_full | Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) |
| title_fullStr | Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) |
| title_full_unstemmed | Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) |
| title_short | Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO) |
| title_sort | study protocol infectious diseases consortium i3d for study on integrated and innovative approaches for management of respiratory infections respiratory infections research and outcome study respiro |
| topic | Medicine, Health and Life Sciences Community-acquired pneumonia Pathogenesis |
| url | https://hdl.handle.net/10356/174723 |
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