Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

Due to the paucity of longitudinal molecular studies of COVID-19, particularly those covering the early stages of infection (Days 1-8 symptom onset), our understanding of host response over the disease course is limited. We perform longitudinal single cell RNA-seq on 286 blood samples from 108 age-...

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Bibliographic Details
Main Authors: Lin, Quy Xiao Xuan, Rajagopalan, Deepa, Gamage, Akshamal M., Tan, Le Min, Venkatesh, Prasanna Nori, Chan, Wharton O. Y., Kumar, Dilip, Agrawal, Ragini, Chen, Yao, Fong, Siew-Wai, Singh, Amit, Sun, Louisa J., Tan, Seow-Yen, Chai, Louis Yi Ann, Somani, Jyoti, Lee, Bernett, Renia, Laurent, Ng, Lisa F. P., Ramanathan, Kollengode, Wang, Lin-Fa, Young, Barnaby, Lye, David, Singhal, Amit, Prabhakar, Shyam
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
COVID-19
Disease severity
Online Access:https://hdl.handle.net/10356/174907

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