Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration
Laser ablation of bio-tissues is the key technology of future surgeries, owing to the merits of submicron accuracy, non-contact operation, and precision control assisted by automation and computer intelligence. Excellent efficiency, minimal collateral damage, biological safety, and tissue selectivit...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/174939 |
| _version_ | 1826123727677423616 |
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| author | Tian, Kan Xiang, Maoxing Wen, Xiangyi Guo, Jinmiao He, Linzhen Yu, Peng Han, Jinghua Peng, Xu Wang, Fan Zhang, Lidan Fu, Zhizhuo Chen, Pengfan Xie, Jing Wang, Zhenzhou Wan, Zhongjun Li, Wenkai Hu, Bo Wang, Weizhe Yang, Xuemei Ding, Chunmei Liu, Yuan Zeng, Yi Li, Yang Wu, Han He, Changtao Feng, Guoying Peng, Yujie Jiang, Xian Li, Jianshu Wang, Qi Jie Zhao, Shengyu Leng, Yuxin Liang, Houkun |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Tian, Kan Xiang, Maoxing Wen, Xiangyi Guo, Jinmiao He, Linzhen Yu, Peng Han, Jinghua Peng, Xu Wang, Fan Zhang, Lidan Fu, Zhizhuo Chen, Pengfan Xie, Jing Wang, Zhenzhou Wan, Zhongjun Li, Wenkai Hu, Bo Wang, Weizhe Yang, Xuemei Ding, Chunmei Liu, Yuan Zeng, Yi Li, Yang Wu, Han He, Changtao Feng, Guoying Peng, Yujie Jiang, Xian Li, Jianshu Wang, Qi Jie Zhao, Shengyu Leng, Yuxin Liang, Houkun |
| author_sort | Tian, Kan |
| collection | NTU |
| description | Laser ablation of bio-tissues is the key technology of future surgeries, owing to the merits of submicron accuracy, non-contact operation, and precision control assisted by automation and computer intelligence. Excellent efficiency, minimal collateral damage, biological safety, and tissue selectivity are the ideal parameters for delicate surgical applications. Here, by exploring the mid-infrared (MIR) resonant ablation and the femtosecond cold processing, tissue ablation with multi-millimeter depth and cellular collateral damage, enabled by a tabletop femtosecond MIR optical parametric amplifier operating at the amide-I resonant wavelength of 6.1 µm, is demonstrated. Remarkably, the collateral damage is observed to be 15, <4, and <1 µm in the porcine cornea, sclera, and articular cartilage, respectively, with multi-millimeter incision depth. In addition, preliminary proof-of-concept experiments of tissue-selective ablation, microchannels on cartilage for drug delivery, laser glaucoma, keratotomy, neurologic tissue incision, dentin deep crater formation, and hypertrophic scarring ablation are demonstrated, which pave the way for high-precision surgical applications with a tabletop solution. |
| first_indexed | 2024-10-01T06:09:05Z |
| format | Journal Article |
| id | ntu-10356/174939 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:09:05Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1749392024-04-17T08:42:18Z Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration Tian, Kan Xiang, Maoxing Wen, Xiangyi Guo, Jinmiao He, Linzhen Yu, Peng Han, Jinghua Peng, Xu Wang, Fan Zhang, Lidan Fu, Zhizhuo Chen, Pengfan Xie, Jing Wang, Zhenzhou Wan, Zhongjun Li, Wenkai Hu, Bo Wang, Weizhe Yang, Xuemei Ding, Chunmei Liu, Yuan Zeng, Yi Li, Yang Wu, Han He, Changtao Feng, Guoying Peng, Yujie Jiang, Xian Li, Jianshu Wang, Qi Jie Zhao, Shengyu Leng, Yuxin Liang, Houkun School of Electrical and Electronic Engineering Sichuan University Shanghai Institute of Optics and Fine Mechanics (SIOM) Chinese Academy of Sciences (CAS) Hymson Laser Technology Group Co., Ltd. The Photonics Institute Centre for OptoElectronics and Biophotonics (COEB) Engineering Medicine, Health and Life Sciences Physics Femtosecond laser Mid-infrared Laser ablation of bio-tissues is the key technology of future surgeries, owing to the merits of submicron accuracy, non-contact operation, and precision control assisted by automation and computer intelligence. Excellent efficiency, minimal collateral damage, biological safety, and tissue selectivity are the ideal parameters for delicate surgical applications. Here, by exploring the mid-infrared (MIR) resonant ablation and the femtosecond cold processing, tissue ablation with multi-millimeter depth and cellular collateral damage, enabled by a tabletop femtosecond MIR optical parametric amplifier operating at the amide-I resonant wavelength of 6.1 µm, is demonstrated. Remarkably, the collateral damage is observed to be 15, <4, and <1 µm in the porcine cornea, sclera, and articular cartilage, respectively, with multi-millimeter incision depth. In addition, preliminary proof-of-concept experiments of tissue-selective ablation, microchannels on cartilage for drug delivery, laser glaucoma, keratotomy, neurologic tissue incision, dentin deep crater formation, and hypertrophic scarring ablation are demonstrated, which pave the way for high-precision surgical applications with a tabletop solution. Ministry of Education (MOE) This work was supported by the National Natural Science Foundation of China (62075144, U22A2090, and U22A20158), Sichuan Outstanding Youth Science and Technology Talents (2022JDJQ0031), Engineering Featured Team Fund of Sichuan University (2020SCUNG105), and the Singapore Ministry of Education grants (MOE-T2EP50120-0009). 2024-04-17T08:42:18Z 2024-04-17T08:42:18Z 2024 Journal Article Tian, K., Xiang, M., Wen, X., Guo, J., He, L., Yu, P., Han, J., Peng, X., Wang, F., Zhang, L., Fu, Z., Chen, P., Xie, J., Wang, Z., Wan, Z., Li, W., Hu, B., Wang, W., Yang, X., ...Liang, H. (2024). Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration. Laser & Photonics Reviews, 18(2), 2300421-. https://dx.doi.org/10.1002/lpor.202300421 1863-8880 https://hdl.handle.net/10356/174939 10.1002/lpor.202300421 2-s2.0-85173513579 2 18 2300421 en MOE-T2EP50120-0009 Laser & Photonics Reviews © 2023 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering Medicine, Health and Life Sciences Physics Femtosecond laser Mid-infrared Tian, Kan Xiang, Maoxing Wen, Xiangyi Guo, Jinmiao He, Linzhen Yu, Peng Han, Jinghua Peng, Xu Wang, Fan Zhang, Lidan Fu, Zhizhuo Chen, Pengfan Xie, Jing Wang, Zhenzhou Wan, Zhongjun Li, Wenkai Hu, Bo Wang, Weizhe Yang, Xuemei Ding, Chunmei Liu, Yuan Zeng, Yi Li, Yang Wu, Han He, Changtao Feng, Guoying Peng, Yujie Jiang, Xian Li, Jianshu Wang, Qi Jie Zhao, Shengyu Leng, Yuxin Liang, Houkun Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration |
| title | Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration |
| title_full | Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration |
| title_fullStr | Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration |
| title_full_unstemmed | Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration |
| title_short | Tissue ablation with multi-millimeter depth and cellular-scale collateral damage by a femtosecond mid-infrared laser tuned to the amide-I vibration |
| title_sort | tissue ablation with multi millimeter depth and cellular scale collateral damage by a femtosecond mid infrared laser tuned to the amide i vibration |
| topic | Engineering Medicine, Health and Life Sciences Physics Femtosecond laser Mid-infrared |
| url | https://hdl.handle.net/10356/174939 |
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