Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease
Parkinson's disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex in a large cohort of early- to mid-stage PD patients (N ...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/174963 |
| _version_ | 1811682440388804608 |
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| author | Vinding, Mikkel C. Waldthaler, Josefine Eriksson, Allison Manting, Cassia Low Ferreira, Daniel Ingvar, Martin Svenningsson, Per Lundqvist, Daniel |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Vinding, Mikkel C. Waldthaler, Josefine Eriksson, Allison Manting, Cassia Low Ferreira, Daniel Ingvar, Martin Svenningsson, Per Lundqvist, Daniel |
| author_sort | Vinding, Mikkel C. |
| collection | NTU |
| description | Parkinson's disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex in a large cohort of early- to mid-stage PD patients (N = 78) on Parkinsonian medication and age- and sex-matched healthy controls (N = 60) using source reconstructed resting-state MEG. We quantified features of the time series data in terms of oscillatory alpha power and central alpha frequency, beta power and central beta frequency, and 1/f broadband characteristics using power spectral density. Furthermore, we characterised transient oscillatory burst events in the mu-beta band time-domain signals. We examined the relationship between these signal features and the patients' disease state, symptom severity, age, sex, and cortical thickness. PD patients and healthy controls differed on PSD broadband characteristics, with PD patients showing a steeper 1/f exponential slope and higher 1/f offset. PD patients further showed a steeper age-related decrease in the burst rate. Out of all the signal features of the sensorimotor activity, the burst rate was associated with increased severity of bradykinesia, whereas the burst duration was associated with axial symptoms. Our study shows that general non-oscillatory features (broadband 1/f exponent and offset) of the sensorimotor signals are related to disease state and oscillatory burst rate scales with symptom severity in PD. |
| first_indexed | 2024-10-01T03:56:52Z |
| format | Journal Article |
| id | ntu-10356/174963 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:56:52Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1749632024-04-21T15:41:16Z Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease Vinding, Mikkel C. Waldthaler, Josefine Eriksson, Allison Manting, Cassia Low Ferreira, Daniel Ingvar, Martin Svenningsson, Per Lundqvist, Daniel Lee Kong Chian School of Medicine (LKCMedicine) Cognitive Neuroimaging Centre Medicine, Health and Life Sciences Parkinson disease Magnetoencephalography Parkinson's disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex in a large cohort of early- to mid-stage PD patients (N = 78) on Parkinsonian medication and age- and sex-matched healthy controls (N = 60) using source reconstructed resting-state MEG. We quantified features of the time series data in terms of oscillatory alpha power and central alpha frequency, beta power and central beta frequency, and 1/f broadband characteristics using power spectral density. Furthermore, we characterised transient oscillatory burst events in the mu-beta band time-domain signals. We examined the relationship between these signal features and the patients' disease state, symptom severity, age, sex, and cortical thickness. PD patients and healthy controls differed on PSD broadband characteristics, with PD patients showing a steeper 1/f exponential slope and higher 1/f offset. PD patients further showed a steeper age-related decrease in the burst rate. Out of all the signal features of the sensorimotor activity, the burst rate was associated with increased severity of bradykinesia, whereas the burst duration was associated with axial symptoms. Our study shows that general non-oscillatory features (broadband 1/f exponent and offset) of the sensorimotor signals are related to disease state and oscillatory burst rate scales with symptom severity in PD. Published version The work was supported by the Swedish Foundation for Strategic Research (SBE 13-0115). The NatMEG facility is supported by Knut and Alice Wallenberg (grant #KAW2011.0207). Open access funding provided by Karolinska Institute. 2024-04-17T06:15:00Z 2024-04-17T06:15:00Z 2024 Journal Article Vinding, M. C., Waldthaler, J., Eriksson, A., Manting, C. L., Ferreira, D., Ingvar, M., Svenningsson, P. & Lundqvist, D. (2024). Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease. NPJ Parkinson's Disease, 10(1), 51-. https://dx.doi.org/10.1038/s41531-024-00669-3 2373-8057 https://hdl.handle.net/10356/174963 10.1038/s41531-024-00669-3 38443402 2-s2.0-85186861585 1 10 51 en NPJ Parkinson's disease © The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Parkinson disease Magnetoencephalography Vinding, Mikkel C. Waldthaler, Josefine Eriksson, Allison Manting, Cassia Low Ferreira, Daniel Ingvar, Martin Svenningsson, Per Lundqvist, Daniel Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease |
| title | Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease |
| title_full | Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease |
| title_fullStr | Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease |
| title_full_unstemmed | Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease |
| title_short | Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease |
| title_sort | oscillatory and non oscillatory features of the magnetoencephalic sensorimotor rhythm in parkinson s disease |
| topic | Medicine, Health and Life Sciences Parkinson disease Magnetoencephalography |
| url | https://hdl.handle.net/10356/174963 |
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