Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants
Inorganic ultraviolet filters such as titanium dioxide nanoparticles are frequently utilized in sunscreens. Numerous in vitro and in vivo toxicological studies have been conducted using pristine standard reference nanomaterials of these inorganic filters. While convenient, this approach is not reali...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
| Published: |
Nanyang Technological University
2024
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/175588 |
| _version_ | 1824454009768902656 |
|---|---|
| author | Kwek, Darien Yu De |
| author2 | Ng Kee Woei |
| author_facet | Ng Kee Woei Kwek, Darien Yu De |
| author_sort | Kwek, Darien Yu De |
| collection | NTU |
| description | Inorganic ultraviolet filters such as titanium dioxide nanoparticles are frequently utilized in sunscreens. Numerous in vitro and in vivo toxicological studies have been conducted using pristine standard reference nanomaterials of these inorganic filters. While convenient, this approach is not realistic as the complex sunscreen formulation environment could transform the physicochemical properties of the nanoparticles and lead to vastly different toxicological outcomes. Therefore, this study focused on characterizing real sunscreen-extracted nanoparticles and evaluating the associated toxicological impacts upon exposure to human keratinocytes and human skin explants. |
| first_indexed | 2025-02-19T03:15:30Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/175588 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:15:30Z |
| publishDate | 2024 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1755882024-05-05T15:38:14Z Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants Kwek, Darien Yu De Ng Kee Woei Interdisciplinary Graduate School (IGS) NTU Institute for Health Technologies KWNG@ntu.edu.sg Engineering Titanium dioxide Nanoparticles Sunscreen Nanotoxicology Skin explants Keratinocytes Engineered nanomaterials Inorganic ultraviolet filters such as titanium dioxide nanoparticles are frequently utilized in sunscreens. Numerous in vitro and in vivo toxicological studies have been conducted using pristine standard reference nanomaterials of these inorganic filters. While convenient, this approach is not realistic as the complex sunscreen formulation environment could transform the physicochemical properties of the nanoparticles and lead to vastly different toxicological outcomes. Therefore, this study focused on characterizing real sunscreen-extracted nanoparticles and evaluating the associated toxicological impacts upon exposure to human keratinocytes and human skin explants. Doctor of Philosophy 2024-04-30T06:19:17Z 2024-04-30T06:19:17Z 2024 Thesis-Doctor of Philosophy Kwek, D. Y. D. (2024). Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/175588 https://hdl.handle.net/10356/175588 10.32657/10356/175588 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Engineering Titanium dioxide Nanoparticles Sunscreen Nanotoxicology Skin explants Keratinocytes Engineered nanomaterials Kwek, Darien Yu De Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| title | Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| title_full | Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| title_fullStr | Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| title_full_unstemmed | Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| title_short | Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| title_sort | understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants |
| topic | Engineering Titanium dioxide Nanoparticles Sunscreen Nanotoxicology Skin explants Keratinocytes Engineered nanomaterials |
| url | https://hdl.handle.net/10356/175588 |
| work_keys_str_mv | AT kwekdarienyude understandingthetoxicologicaleffectsofnanoparticlesextractedfromsunscreensonhumankeratinocytesandskinexplants |