Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions
There is emerging evidence that parent-child neural synchrony plays a mechanistic role in social, emotional, and cognitive functions such as social attunement, emotional regulation, and learning. However, little is known about the sequelae of synchronisation of brain oscillations in parent and child...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2024
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| Online Access: | https://hdl.handle.net/10356/175771 |
| _version_ | 1811692497145954304 |
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| author | Lim, Megan |
| author2 | Victoria Leong |
| author_facet | Victoria Leong Lim, Megan |
| author_sort | Lim, Megan |
| collection | NTU |
| description | There is emerging evidence that parent-child neural synchrony plays a mechanistic role in social, emotional, and cognitive functions such as social attunement, emotional regulation, and learning. However, little is known about the sequelae of synchronisation of brain oscillations in parent and child and whether neural synchrony potentially has a causal role in modulating social behaviours. Mice models offer a promising avenue for investigating these gaps in literature given the availability of tools such as optogenetics to manipulate neural activity. Hence, this study aims to investigate how synchronisation of the medial prefrontal cortex (mPFC) of dams and pups might influence their social behaviours. An optogenetic mouse model was utilised to allow for precise control of concurrent activation of the mPFC at 40Hz-40Hz frequency in freely interacting dyads. Overall, synchronised stimulation of dyads resulted in significantly longer durations of some social behaviours, e.g., close proximity, and higher likelihoods of dam-pup interactions. These findings contribute to the theoretical advancement of two-person neuroscience and highlight important directions for future research in child development. This study provides supporting evidence that neural synchrony can causally modulate specific social interactions, and increased synchronisation within dyads leads to increased likelihood and duration of social interactions. |
| first_indexed | 2024-10-01T06:36:43Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/175771 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:36:43Z |
| publishDate | 2024 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1757712024-05-06T15:33:14Z Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions Lim, Megan Victoria Leong School of Biological Sciences VictoriaLeong@ntu.edu.sg Social Sciences Optogenetic mice model Inter-neural synchrony Mother-child interactions There is emerging evidence that parent-child neural synchrony plays a mechanistic role in social, emotional, and cognitive functions such as social attunement, emotional regulation, and learning. However, little is known about the sequelae of synchronisation of brain oscillations in parent and child and whether neural synchrony potentially has a causal role in modulating social behaviours. Mice models offer a promising avenue for investigating these gaps in literature given the availability of tools such as optogenetics to manipulate neural activity. Hence, this study aims to investigate how synchronisation of the medial prefrontal cortex (mPFC) of dams and pups might influence their social behaviours. An optogenetic mouse model was utilised to allow for precise control of concurrent activation of the mPFC at 40Hz-40Hz frequency in freely interacting dyads. Overall, synchronised stimulation of dyads resulted in significantly longer durations of some social behaviours, e.g., close proximity, and higher likelihoods of dam-pup interactions. These findings contribute to the theoretical advancement of two-person neuroscience and highlight important directions for future research in child development. This study provides supporting evidence that neural synchrony can causally modulate specific social interactions, and increased synchronisation within dyads leads to increased likelihood and duration of social interactions. Bachelor's degree 2024-05-06T07:20:22Z 2024-05-06T07:20:22Z 2024 Final Year Project (FYP) Lim, M. (2024). Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/175771 https://hdl.handle.net/10356/175771 en application/pdf Nanyang Technological University |
| spellingShingle | Social Sciences Optogenetic mice model Inter-neural synchrony Mother-child interactions Lim, Megan Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions |
| title | Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions |
| title_full | Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions |
| title_fullStr | Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions |
| title_full_unstemmed | Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions |
| title_short | Optogenetic manipulation of dyadic dam-pup prefrontal cortical activity to modulate social interactions |
| title_sort | optogenetic manipulation of dyadic dam pup prefrontal cortical activity to modulate social interactions |
| topic | Social Sciences Optogenetic mice model Inter-neural synchrony Mother-child interactions |
| url | https://hdl.handle.net/10356/175771 |
| work_keys_str_mv | AT limmegan optogeneticmanipulationofdyadicdampupprefrontalcorticalactivitytomodulatesocialinteractions |