Inhalable biomimetic nanomotor for pulmonary thrombus therapy
The complications of pulmonary thrombosis caused by the coronavirus pneumonia have created an unprecedented clinical need for efficient targeted therapy of pulmonary thrombosis. Here, we designed an inhalable engineered platelet nanomotor (MHLP) that could mimic platelet function to cross the pulmon...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/176032 |
| _version_ | 1824454240509100032 |
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| author | Zhang, Kai Long, Yuying Li, Shuting Zhao, Yanli Han, Heyou |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Zhang, Kai Long, Yuying Li, Shuting Zhao, Yanli Han, Heyou |
| author_sort | Zhang, Kai |
| collection | NTU |
| description | The complications of pulmonary thrombosis caused by the coronavirus pneumonia have created an unprecedented clinical need for efficient targeted therapy of pulmonary thrombosis. Here, we designed an inhalable engineered platelet nanomotor (MHLP) that could mimic platelet function to cross the pulmonary mucosal barrier and target pulmonary thrombus. The MHLP could respond to the thrombotic microenvironment by using reactive oxygen species as the fuel to produce oxygen and nitric oxide for promoting the release of the loaded anticoagulant drug hirudin. These gases can also regulate the thrombo-inflammatory microenvironment, promote the polarization of macrophages from pro-inflammatory to anti-inflammatory phenotype, and downregulate the expression level of inflammatory factors. Through the two-pronged strategy of anticoagulation and regulation of the inflammatory microenvironment, MHLP demonstrates the effect of safely dissolving pulmonary thrombus and preventing recurrence. |
| first_indexed | 2025-02-19T03:19:10Z |
| format | Journal Article |
| id | ntu-10356/176032 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:19:10Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1760322024-05-13T00:41:34Z Inhalable biomimetic nanomotor for pulmonary thrombus therapy Zhang, Kai Long, Yuying Li, Shuting Zhao, Yanli Han, Heyou School of Chemistry, Chemical Engineering and Biotechnology Engineering Drug delivery Inhalable biomimetic nanomotor The complications of pulmonary thrombosis caused by the coronavirus pneumonia have created an unprecedented clinical need for efficient targeted therapy of pulmonary thrombosis. Here, we designed an inhalable engineered platelet nanomotor (MHLP) that could mimic platelet function to cross the pulmonary mucosal barrier and target pulmonary thrombus. The MHLP could respond to the thrombotic microenvironment by using reactive oxygen species as the fuel to produce oxygen and nitric oxide for promoting the release of the loaded anticoagulant drug hirudin. These gases can also regulate the thrombo-inflammatory microenvironment, promote the polarization of macrophages from pro-inflammatory to anti-inflammatory phenotype, and downregulate the expression level of inflammatory factors. Through the two-pronged strategy of anticoagulation and regulation of the inflammatory microenvironment, MHLP demonstrates the effect of safely dissolving pulmonary thrombus and preventing recurrence. This work was supported by the National Key Research and Development Program of China (2021YFD1400800). 2024-05-13T00:41:34Z 2024-05-13T00:41:34Z 2024 Journal Article Zhang, K., Long, Y., Li, S., Zhao, Y. & Han, H. (2024). Inhalable biomimetic nanomotor for pulmonary thrombus therapy. Nano Today, 55, 102171-. https://dx.doi.org/10.1016/j.nantod.2024.102171 1748-0132 https://hdl.handle.net/10356/176032 10.1016/j.nantod.2024.102171 2-s2.0-85183891979 55 102171 en Nano Today © 2024 Elsevier Ltd. All rights reserved. |
| spellingShingle | Engineering Drug delivery Inhalable biomimetic nanomotor Zhang, Kai Long, Yuying Li, Shuting Zhao, Yanli Han, Heyou Inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| title | Inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| title_full | Inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| title_fullStr | Inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| title_full_unstemmed | Inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| title_short | Inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| title_sort | inhalable biomimetic nanomotor for pulmonary thrombus therapy |
| topic | Engineering Drug delivery Inhalable biomimetic nanomotor |
| url | https://hdl.handle.net/10356/176032 |
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