Exploring brain development as a mediator for adverse childhood experiences and resilience
Adverse childhood experiences (ACEs) refer to negative experiences between 0 – 18 years old. This period is developmentally sensitive to environmental influences and ACEs increase the risk of somatic and psychological dysfunction across the lifespan. High global prevalence makes research into its ne...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2024
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| Online Access: | https://hdl.handle.net/10356/176435 |
| _version_ | 1811695318168764416 |
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| author | Tan, Ivan Jia Le |
| author2 | Darren Yeo |
| author_facet | Darren Yeo Tan, Ivan Jia Le |
| author_sort | Tan, Ivan Jia Le |
| collection | NTU |
| description | Adverse childhood experiences (ACEs) refer to negative experiences between 0 – 18 years old. This period is developmentally sensitive to environmental influences and ACEs increase the risk of somatic and psychological dysfunction across the lifespan. High global prevalence makes research into its neurobiological mechanisms paramount.
Outcome resilience refers to adaptive functioning post-ACEs, inferred by the ability to function within everyday environments. This study inferred outcome resilience from adaptive functioning in educational, social settings, and neurocognitive domains.
Past literature found the hippocampus, amygdala, and pre-frontal cortex were associated with ACEs-resilience. However, studies establishing a causal relationship between ACEs-brain-resilience are limited. Hence, this study aims to determine if these brain regions mediate ACEs-resilience.
The Adolescent Brain Cognitive Development Study (ABCD) is an ongoing longitudinal study involving 11,878 participants. Gray matter volumes and volume changes from 2016 – 2021 were used for mediation analysis.
There is no evidence to support that these brain regions mediate the relationship between ACEs-resilience. However, across the three resilience domains, different brain structures had significant associations with minimal overlaps. This suggests that the domains do not redundantly measure the same constructs. Future research should not treat resilience as a catch-all unitary construct, measuring various domains of adaptive functioning. |
| first_indexed | 2024-10-01T07:21:34Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/176435 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:21:34Z |
| publishDate | 2024 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1764352024-05-20T15:33:09Z Exploring brain development as a mediator for adverse childhood experiences and resilience Tan, Ivan Jia Le Darren Yeo School of Biological Sciences darrenyeo@ntu.edu.sg Social Sciences Resilience Neuroscience Psychology Adverse childhood experiences Mediation Adverse childhood experiences (ACEs) refer to negative experiences between 0 – 18 years old. This period is developmentally sensitive to environmental influences and ACEs increase the risk of somatic and psychological dysfunction across the lifespan. High global prevalence makes research into its neurobiological mechanisms paramount. Outcome resilience refers to adaptive functioning post-ACEs, inferred by the ability to function within everyday environments. This study inferred outcome resilience from adaptive functioning in educational, social settings, and neurocognitive domains. Past literature found the hippocampus, amygdala, and pre-frontal cortex were associated with ACEs-resilience. However, studies establishing a causal relationship between ACEs-brain-resilience are limited. Hence, this study aims to determine if these brain regions mediate ACEs-resilience. The Adolescent Brain Cognitive Development Study (ABCD) is an ongoing longitudinal study involving 11,878 participants. Gray matter volumes and volume changes from 2016 – 2021 were used for mediation analysis. There is no evidence to support that these brain regions mediate the relationship between ACEs-resilience. However, across the three resilience domains, different brain structures had significant associations with minimal overlaps. This suggests that the domains do not redundantly measure the same constructs. Future research should not treat resilience as a catch-all unitary construct, measuring various domains of adaptive functioning. Bachelor's degree 2024-05-16T13:15:12Z 2024-05-16T13:15:12Z 2024 Final Year Project (FYP) Tan, I. J. L. (2024). Exploring brain development as a mediator for adverse childhood experiences and resilience. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/176435 https://hdl.handle.net/10356/176435 en application/pdf Nanyang Technological University |
| spellingShingle | Social Sciences Resilience Neuroscience Psychology Adverse childhood experiences Mediation Tan, Ivan Jia Le Exploring brain development as a mediator for adverse childhood experiences and resilience |
| title | Exploring brain development as a mediator for adverse childhood experiences and resilience |
| title_full | Exploring brain development as a mediator for adverse childhood experiences and resilience |
| title_fullStr | Exploring brain development as a mediator for adverse childhood experiences and resilience |
| title_full_unstemmed | Exploring brain development as a mediator for adverse childhood experiences and resilience |
| title_short | Exploring brain development as a mediator for adverse childhood experiences and resilience |
| title_sort | exploring brain development as a mediator for adverse childhood experiences and resilience |
| topic | Social Sciences Resilience Neuroscience Psychology Adverse childhood experiences Mediation |
| url | https://hdl.handle.net/10356/176435 |
| work_keys_str_mv | AT tanivanjiale exploringbraindevelopmentasamediatorforadversechildhoodexperiencesandresilience |