3D printing of asymmetric re-entrant structures for microfluidics

Traditional microfluidic fabrication methods are often limited by complexity and cost. In contrast, 3D printing offers rapid prototyping and intricate geometries, especially beneficial for asymmetric re-entrant structures. Techniques like stereolithography (SLA), digital light processing (DLP), and...

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Main Author: Lim, Yu Fong
Other Authors: Zhou Kun
Format: Final Year Project (FYP)
Language:English
Published: Nanyang Technological University 2024
Subjects:
Online Access:https://hdl.handle.net/10356/177870
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author Lim, Yu Fong
author2 Zhou Kun
author_facet Zhou Kun
Lim, Yu Fong
author_sort Lim, Yu Fong
collection NTU
description Traditional microfluidic fabrication methods are often limited by complexity and cost. In contrast, 3D printing offers rapid prototyping and intricate geometries, especially beneficial for asymmetric re-entrant structures. Techniques like stereolithography (SLA), digital light processing (DLP), and selective laser sintering (SLS) enable high-resolution printing of complex features crucial for efficient fluid control. Applications span from lab-on-a-chip diagnostics to organ-on-a-chip platforms and microscale reactors. Customized microfluidic devices with tailored functionalities are empowering advancements in biomedical engineering, offering solutions for complex fluidic challenges at the microscale. Despite significant advancements, the majority of natural and artificial structures struggle to enhance the Laplace pressure difference or capillary force, resulting in a low unidirectional capillary height (< 30 mm). In this study, asymmetric re-entrant structures featuring long horizontal overhangs and interconnected forward/lateral microchannels were fabricated using three-dimensional (3D) printing. This led to substantially increased unidirectional capillary heights of 102.3 mm and 44.6 mm for water and ethanol, respectively, nearing the theoretical limits. Building upon both asymmetric and symmetric re-entrant structures, we introduce the concept of liquid transistors to programmatically adjust capillary rise. These liquid transistors hold promise for developing functional microfluidic devices capable of high-efficiency liquid-patterning, desalination, and biochemical microreactions in 3D space.
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spelling ntu-10356/1778702024-06-08T16:51:02Z 3D printing of asymmetric re-entrant structures for microfluidics Lim, Yu Fong Zhou Kun School of Mechanical and Aerospace Engineering kzhou@ntu.edu.sg Engineering Physics Traditional microfluidic fabrication methods are often limited by complexity and cost. In contrast, 3D printing offers rapid prototyping and intricate geometries, especially beneficial for asymmetric re-entrant structures. Techniques like stereolithography (SLA), digital light processing (DLP), and selective laser sintering (SLS) enable high-resolution printing of complex features crucial for efficient fluid control. Applications span from lab-on-a-chip diagnostics to organ-on-a-chip platforms and microscale reactors. Customized microfluidic devices with tailored functionalities are empowering advancements in biomedical engineering, offering solutions for complex fluidic challenges at the microscale. Despite significant advancements, the majority of natural and artificial structures struggle to enhance the Laplace pressure difference or capillary force, resulting in a low unidirectional capillary height (< 30 mm). In this study, asymmetric re-entrant structures featuring long horizontal overhangs and interconnected forward/lateral microchannels were fabricated using three-dimensional (3D) printing. This led to substantially increased unidirectional capillary heights of 102.3 mm and 44.6 mm for water and ethanol, respectively, nearing the theoretical limits. Building upon both asymmetric and symmetric re-entrant structures, we introduce the concept of liquid transistors to programmatically adjust capillary rise. These liquid transistors hold promise for developing functional microfluidic devices capable of high-efficiency liquid-patterning, desalination, and biochemical microreactions in 3D space. Bachelor's degree 2024-06-03T03:49:11Z 2024-06-03T03:49:11Z 2024 Final Year Project (FYP) Lim, Y. F. (2024). 3D printing of asymmetric re-entrant structures for microfluidics. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/177870 https://hdl.handle.net/10356/177870 en A181 application/pdf Nanyang Technological University
spellingShingle Engineering
Physics
Lim, Yu Fong
3D printing of asymmetric re-entrant structures for microfluidics
title 3D printing of asymmetric re-entrant structures for microfluidics
title_full 3D printing of asymmetric re-entrant structures for microfluidics
title_fullStr 3D printing of asymmetric re-entrant structures for microfluidics
title_full_unstemmed 3D printing of asymmetric re-entrant structures for microfluidics
title_short 3D printing of asymmetric re-entrant structures for microfluidics
title_sort 3d printing of asymmetric re entrant structures for microfluidics
topic Engineering
Physics
url https://hdl.handle.net/10356/177870
work_keys_str_mv AT limyufong 3dprintingofasymmetricreentrantstructuresformicrofluidics